In this paper, a mathematical model is established to examine the impacts of Stefan blowing on the unsteady magnetohydrodynamic (MHD) flow of an electrically conducting nanofluid over a stretching sheet in the existence of thermal radiation, Arrhenius activation energy and chemical reaction. It is proposed to use the Buongiorno nanofluid model to synchronize the effects of magnetic and electric fields on the velocity and temperature fields to enhance the thermal conductivity. We utilized suitable transformation to simplify the governing partial differential equation (PDEs) into a set of nonlinear ordinary differential equations (ODEs). The obtained equations were solved numerically with the help of the Runge–Kutta 4th order using the shooting technique in a MATLAB environment. The impact of the developing flow parameters on the flow characteristics is analyzed appropriately through graphs and tables. The velocity, temperature, and nanoparticle concentration profiles decrease for various values of involved parameters, such as hydrodynamic slip, thermal slip and solutal slip. The nanoparticle concentration profile declines in the manifestation of the chemical reaction rate, whereas a reverse demeanor is noted for the activation energy. The validation was conducted using earlier works published in the literature, and the results were found to be incredibly consistent.