scholarly journals Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method

2016 ◽  
Vol 57 (3) ◽  
pp. 1432 ◽  
Author(s):  
Reinhard Told ◽  
Lin Wang ◽  
Grant Cull ◽  
Simon J. Thompson ◽  
Claude F. Burgoyne ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Nonhuman Primate ◽  
Retinal Blood Flow ◽  
Nerve Transection ◽  
Dual Beam ◽  
Microsphere Method ◽  
Optic Nerve Transection

Effect of optic nerve transection onN-acetylaspartylglutamate immunoreactivity in the primary and accessory optic projection systems in the rat

1991 ◽  
Vol 538 (1) ◽  
pp. 86-94 ◽  
Author(s):  
J.R. Moffett ◽  
L.C. Williamson ◽  
J.H. Neale ◽  
M. Palkovits ◽  
M.A.A. Namboodiri
Keyword(s):  
Optic Nerve ◽  
Nerve Transection ◽  
Optic Nerve Transection

scholarly journals Comparing modes of delivery of a combination of ion channel inhibitors for limiting secondary degeneration following partial optic nerve transection

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Lillian M. Toomey ◽  
Carole A. Bartlett ◽  
Nikolas Gavriel ◽  
Terence McGonigle ◽  
Maimuna Majimbi ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ion Channel ◽  
Local Delivery ◽  
Nerve Transection ◽  
Secondary Degeneration ◽  
Injury Site ◽  
Myelin Structure ◽  
Ion Channel Inhibitors ◽  
Optic Nerve Transection ◽  
Inhibitor Combination

Abstract Injury to the central nervous system is exacerbated by secondary degeneration. Previous research has shown that a combination of orally and locally administered ion channel inhibitors following partial optic nerve injury protects the myelin sheath and preserves function in the ventral optic nerve, vulnerable to secondary degeneration. However, local administration is often not clinically appropriate. This study aimed to compare the efficacy of systemic and local delivery of the ion channel inhibitor combination of lomerizine, brilliant blue G (BBG) and YM872, which inhibits voltage-gated calcium channels, P2X7 receptors and Ca2+ permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors respectively. Following a partial optic nerve transection, adult female PVG rats were treated with BBG and YM872 delivered via osmotic mini pump directly to the injury site, or via intraperitoneal injection, both alongside oral administration of lomerizine. Myelin structure was preserved with both delivery modes of the ion channel inhibitor combination. However, there was no effect of treatment on inflammation, either peripherally or at the injury site, or on the density of oligodendroglial cells. Taken together, the data indicate that even at lower concentrations, the combinatorial treatment may be preserving myelin structure, and that systemic and local delivery are comparable at improving outcomes following neurotrauma.

Effects of 0.005% Latanoprost on Optic Nerve Head and Peripapillary Retinal Blood Flow

1999 ◽  
Vol 213 (6) ◽  
pp. 355-359 ◽  
Author(s):  
Gong Je Seong ◽  
Hyung Keun Lee ◽  
Young Jae Hong
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Retinal Blood Flow

scholarly journals Response of Retinal Blood Flow to Systemic Hyperoxia as Measured with Dual-Beam Bidirectional Doppler Fourier-Domain Optical Coherence Tomography

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45876 ◽  
Author(s):  
René M. Werkmeister ◽  
Stefan Palkovits ◽  
Reinhard Told ◽  
Martin Gröschl ◽  
Rainer A. Leitgeb ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Retinal Blood Flow ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Dual Beam

scholarly journals ERG changes in albino and pigmented mice after optic nerve transection

2010 ◽  
Vol 50 (21) ◽  
pp. 2176-2187 ◽  
Author(s):  
Luis Alarcón-Martínez ◽  
Marcelino Avilés-Trigueros ◽  
Caridad Galindo-Romero ◽  
Javier Valiente-Soriano ◽  
Marta Agudo-Barriuso ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Transection ◽  
Optic Nerve Transection
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