Effect of coagulation bath parameters on the morphology and absorption behavior of a skin–core filament based on biomedical polyurethane and native silk fibroin microparticles

2019 ◽  
Vol 90 (3-4) ◽  
pp. 460-468 ◽  
Author(s):  
Yan Zhuang ◽  
Han Wang ◽  
Linfeng Wang ◽  
Changjun Liu ◽  
Yuan Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Water Absorption ◽  
Silk Fibroin ◽  
Controlled Drug Release ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Electron Microscopy Analysis ◽  
Potential Applications ◽  
Spinning Process ◽  
Biomedical Polyurethane

This study investigates the effect of the constituents and temperature of a coagulation bath on the morphology and water absorption behavior of a skin–core filament, which has potential application in the field of controlled drug release, based on biomedical polyurethane (BPU) and native silk fibroin microparticles (NSFPs). BPU solution and BPU/NSFP blend solution were extruded from the cortex and core channel of a coaxial double injector into a coagulation bath with different constituents and at different temperatures to form filaments. Scanning electron microscopy analysis of the skin–core filament prepared by wet-spinning revealed that the addition of ethanol decreased the exchange speed between the solvent and non-solvent and led to the formation of micropores on the surface. Meanwhile, the interface between the cortex and core became pronounced and the water absorption capability of the filament decreased with increasing ethanol concentration in the coagulation bath. The high temperature of the coagulation bath also improved the exchange speed between the solvent and non-solvent; however, its effect on the morphology of the filament was weak. Thus, a skin–core filament with different morphologies and water absorption behaviors was fabricated by controlling the constituents and temperature of the coagulation bath during the wet-spinning process. This skin–core filament has potential applications in controlled drug release.

scholarly journals Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 47
Author(s):  
Henrique Nunes da Silva ◽  
Milena Costa da Silva ◽  
Flavia Suzany Ferreira dos Santos ◽  
José Alberto Campos da Silva Júnior ◽  
Rossemberg Cardoso Barbosa ◽  
...  
Keyword(s):  
Sodium Hydroxide Solution ◽  
Tensile Tests ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Physiological Properties ◽  
Potential Applications ◽  
Spinning Process ◽  
The Individual ◽  
Typical Skin

This study aimed to develop meshes from the weaving of mono- and multifilament wet-spun chitosan (CS), for possible biomedical applications. In the wet-spinning process, CS solution (4% w/v) was extruded in a coagulation bath containing 70% sodium hydroxide solution (0.5 M), and 30% methanol was used. The multifilament thread was prepared by twisted of two and three monofilaments. CS threads obtained were characterized by tensile tests and scanning electron microscopy (SEM). Moreover, it was verified from the morphological tests that threads preserve the characteristics of the individual filaments and present typical “skin-core” microstructure obtained by wet spinning. CS woven meshes obtained were evaluated by optical microscopy (OM), tensile test, swelling degree, and in vitro enzymatic biodegradation. Mechanical properties, biodegradation rate, and amount of fluid absorbed of CS woven meshes were influenced by thread configuration. Hydrated CS meshes showed a larger elastic zone than the dry state. Therefore, CS woven meshes were obtained with modular properties from thread configuration used in weaving, suggesting potential applications in the biomedical field, like dressings, controlled drug delivery systems, or mechanical support.

scholarly journals Silk fibroin/chitosan/alginate multilayer membranes as a system for controlled drug release in wound healing

2020 ◽  
Vol 152 ◽  
pp. 803-811 ◽  
Author(s):  
Murilo Santos Pacheco ◽  
Gustavo Eiji Kano ◽  
Letícia de Almeida Paulo ◽  
Patricia Santos Lopes ◽  
Mariana Agostini de Moraes
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Silk Fibroin ◽  
Controlled Drug Release ◽  
Multilayer Membranes

Fabrication of the Colored PMIA Fibers by Wet Spinning: Effect of Spinning Parameters on the Coagulation Process

2014 ◽  
Vol 9 (1) ◽  
pp. 155892501400900
Author(s):  
Liqi Liu ◽  
Lei Chen ◽  
Zuming Hu ◽  
Junrong Yu ◽  
Jing-Zhu ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Aromatic Polyamide ◽  
Stretch Ratio ◽  
Coagulation Bath ◽  
Wet Spinning ◽  
Ultrasonic Oscillation ◽  
Coagulation Process ◽  
Polyamide Fiber ◽  
Spinning Process ◽  
Oscillation Method

The poly (m-phenylene isophthalamide) (PMIA) fiber, which can be prepared by wet spinning, is a kind of aromatic polyamide fiber. The spinning parameters could influence the performance and structure of the colored PMIA fiber such as the diffusion coefficient and coagulation bath. In this study, the PMIA spinning solutions doped with Color Inde purple 120 were first commixed in a pressurizer and then spun into a coagulation bath under a pressure about 0.3 MPa. In the coagulation bath, the pure or dope-dyed PMIA fibers were prepared by wet spinning at 323 K, and then the as-spun fibers were extracted by an ultrasonic oscillation method. The effects of jet stretch ratio, temperature, and concentration of the coagulation bath on the ratio of diffusion coefficient of solvent to coagulator were analyzed during the spinning process of dope-dyed PMIA fibers. The properties and structures of the colored PMIA fibers were characterized by SEM. Finally the most optimized spinning technology of the dope-dyed PMIA fiber was obtained and the dope-dyed PMIA fibers were successfully fabricated through wet spinning.

scholarly journals Microstructure Transitions and Dry-Wet Spinnability of Silk Fibroin Protein from Waste Silk Quilt

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1622 ◽  
Author(s):  
Xin Zhang ◽  
Zhijuan Pan
Keyword(s):  
Silk Fibroin ◽  
Coagulation Bath ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Leading Role ◽  
Regenerated Silk Fibroin ◽  
Spinning Process ◽  
Silk Fabrics ◽  
The Many ◽  
Conformation Transitions

With excellent biocompatibility and biodegradability, silk fibroin has been developed into many protein materials. For producing regenerated silk fibroin (RSF) fibers, the conformation transition of silk fibroin needs to be thoroughly studied during the spinning process. Since the many silk fabrics that are discarded comprise an increasing waste of resources and increase the pressure on the environment, in this paper, waste silk fiber was recycled in an attempt to prepare regenerated fibroin fiber by dry-wet spinning. Ethanol was the coagulation bath. The rheological properties of all the RSF solutions were investigated to acquire rheology curves and non-Newtonian indexes for spinnability analysis. Four stages of the spinning process were carried out to obtain RSF samples and study their conformation transitions, crystallization, and thermal properties by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, and differential scanning calorimetry. Quantitative analysis of the FTIR results was performed to obtain specific data regarding the contents of the secondary structures. The results showed that higher concentration spinning solutions had better spinnability. As the spinning process progressed, random coils were gradually converted into β-sheets and crystallization increased. Among the different influencing factors, the ethanol coagulation bath played a leading role in the conformation transitions of silk fibroin.

scholarly journals 5-Aminosalicylic Acid Loaded Chitosan-Carrageenan Hydrogel Beads with Potential Application for the Treatment of Inflammatory Bowel Disease

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2463
Author(s):  
Cristina Elena Stavarache ◽  
Adi Ghebaur ◽  
Sorina Dinescu ◽  
Iuliana Samoilă ◽  
Eugeniu Vasile ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Drug Release ◽  
Bowel Disease ◽  
Sodium Tripolyphosphate ◽  
Chemical Characterization ◽  
Controlled Drug Release ◽  
Aminosalicylic Acid ◽  
Drug Release Profile ◽  
Potential Applications ◽  
Inflammatory Bowel

The aim of our work is to prepare mucoadhesive particles with biopolymers and 5-Aminosalicylic acid (5ASA) using the ionotropic gelation technique to ensure a controlled drug release at the colon level with potential applications in the treatment of intestinal bowel disease (IBD). The preparation of particles through the crosslinking of Chitosan (CS) with sodium tripolyphosphate (TPP) using different mass ratios and the influence of the k-Carrageenan (kCG) layer were studied. UV–VIS spectrometry was employed to assess encapsulation efficiency and drug release profile of 5ASA. The particles were investigated using FT-IR spectrometry for chemical characterization and the DLS results highlighted a monodisperse particle size distribution. The morphology of the polymeric beads was investigated using micro-computer tomography (µCT) and Scanning Electron Microscopy (SEM). Particles based on Chitosan and k-Carrageenan were able to incorporate and preserve 5ASA in an acidic and alkaline medium. The 5ASA loaded polymeric particles obtained after immersion for 1 h in kCG solution exhibited the lowest release rate in pH = 1.2. Biocompatibility studies performed on all of the particles displayed a good viability for the CCD 841 CoN cells and low cytotoxicity. All of the results have shown that these new biomaterials could be a versatile platform of targeted carriers with potential applications in inflammatory bowel disease treatment.

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