scholarly journals The Frequency and Clinical Assessment of COVID-19 in Patients With Chronic Rhinosinusitis

2021 ◽  
pp. 014556132110380
Author(s):  
Allahkarm Akhlaghi ◽  
Amirhossein Darabi ◽  
Marzieh Mahmoodi ◽  
Ali Movahed ◽  
Reza Kaboodkhani ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chronic Rhinosinusitis ◽  
Low Frequency ◽  
Airway Disease ◽  
Polymerase Chain Reaction Test ◽  
Average Score ◽  
Emotional Symptoms ◽  
Cross Sectional ◽  
One Year ◽  
Snot 22

Background: Chronic rhinosinusitis (CRS), as an inflammatory airway disease, could be a risk factor for COVID-19 patients. This study aimed to investigate the frequency and severity of symptoms of COVID-19 in patients with CRS and to assess the association between the status of CRS symptoms and the quality of life (QoL) of the patients. Methods: In this observational and cross-sectional study, 207 adult CRS patients participated. The patients, who presented the symptoms of COVID-19, were examined by taking the reverse transcription–polymerase chain reaction test. A questionnaire was completed by each patient, regarding their demographic and clinical data. In addition, the GA2LEN and Sino-Nasal Outcome Test (SNOT-22) standard questionnaires were used to identify the comorbid allergic condition and QoL of CRS patients. Results: The frequency of patients with COVID-19 was 25 (12.1%) of which 22 were treated as outpatients, 2 of them admitted in wards and 1 at intensive care unit. The severity of hyposmia in the patients was 2 (8%) as mild, 5 (20%) moderate, and 11 (72%) as anosmia. The most common allergic and underlying comorbid diseases were allergic rhinitis (88%) and thyroid disorders (28%). Further, the average SNOT-22 score in 4 SNOT-22 domains (nasal, otologic, sleep, and emotional symptoms) was significantly decreased in CRS patients after a period of one year since the pandemic started (40.1 ± 18.0 vs. 46.3 ± 17.7; P < .0001). Discussion: This study showed a low frequency of COVID-19 in patients with CRS and about the same rate of infection positivity in the general population; therefore, we concluded that CRS could not be considered as a risk factor for COVID-19. Interestingly, the lower average score of SNOT-22 after one year of the pandemic in the patients with CRS confirmed the necessity for performing the standard health protocols by the patients.

scholarly journals Mucosal Eosinophilia and Neutrophilia Are Not Associated With QOL or Olfactory Function in Chronic Rhinosinusitis

2021 ◽  
pp. 194589242098743
Author(s):  
Nyssa F. Farrell ◽  
Jess C. Mace ◽  
David A. Sauer ◽  
Andrew J. Thomas ◽  
Mathew Geltzeiler ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyposis ◽  
Cross Sectional Study ◽  
Olfactory Function ◽  
Sinus Surgery ◽  
Small Subset ◽  
Cross Sectional ◽  
Snot 22

Background Chronic rhinosinusitis (CRS) is often differentiated by histopathologic phenotypes (eosinophilic versus neutrophilic), which may impact disease severity measures and outcomes. As such, it has been suggested that counts of cellular elements be included as part of a standard pathological report following endoscopic sinus surgery (ESS). Objectives This cross-sectional study evaluated associations of mucosal eosinophilia and neutrophilia with measures of quality-of-life (QoL) and olfactory function. Methods Patients with medically refractory CRS completed the SNOT-22 survey and Brief Smell Identification Test (BSIT) at enrollment. In addition, baseline Lund-Mackay computed tomography (CT) and Lund-Kennedy endoscopy scores were collected. Ethmoid mucosa was biopsied during ESS and reviewed using microscopy to quantify densest infiltrate of eosinophils or neutrophils per high-powered-field (HPF). Eosinophilic CRS (eCRS) and neutrophilic CRS (nCRS), both with and without nasal polyposis (NP), were compared across SNOT-22 and BSIT scores. Results 77/168 patients demonstrated mucosal eosinophilia (eCRS) while a total of 42/168 patients demonstrated mucosal neutrophilia (nCRS). After adjusting for polyp status, 35/168 had eCRSsNP, 42/168 eCRSwNP, 75/168 non-eCRSsNP, 16/168 non-eCRSwNP. Additionally, 22/161 were noted to have nCRSsNP, 20/161 nCRSwNP, 84/161 non-nCRSwNP, and 35/161 non-nCRSsNP. A small subset of patients demonstrated both eosinophilia and neutrophilia: 14 CRSwNP and 7 CRSsNP. When evaluating average Lund-Mackay Scores (LMS), significant differences existed between non-eCRSsNP and eCRSsNP (p = 0.006). However, after controlling for nasal polyps, eosinophilia did not significantly associate with differences in the Lund-Kennedy Score. Neutrophilia did not significantly associate with any changes in LMS or LKS after controlling for NP. Eosinophilic and neutrophilic histopathologic subtypes did not significantly associate with differences in baseline SNOT-22 or BSIT measures after controlling for NP. Conclusion Neither the presence of mucosal eosinophilia nor mucosal neutrophilia demonstrated significant associations with SNOT-22 quality-of-life or BSIT olfactory function scores when controlling for comorbid nasal polyposis.

Clinical Traits Characterizing an Exacerbation-Prone Phenotype in Chronic Rhinosinusitis

2019 ◽  
Vol 161 (5) ◽  
pp. 890-896 ◽  
Author(s):  
Katie M. Phillips ◽  
Eric Barbarite ◽  
Lloyd P. Hoehle ◽  
David S. Caradonna ◽  
Stacey T. Gray ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Disease Burden ◽  
Tertiary Care ◽  
Symptom Burden ◽  
Cross Sectional ◽  
Patient Reported ◽  
Oral Corticosteroids ◽  
Sinonasal Outcome Test ◽  
Snot 22

Objective Acute exacerbation of chronic rhinosinusitis (AECRS) is associated with significant quality-of-life decreases. We sought to determine characteristics associated with an exacerbation-prone phenotype in chronic rhinosinusitis (CRS). Study Design Cross-sectional. Setting Tertiary care rhinology clinic. Subjects Patients with CRS (N = 209). Methods Patient-reported number of sinus infections, CRS-related antibiotics, and CRS-related oral corticosteroids taken in the last 12 months were used as metrics for AECRS frequency. Sinonasal symptom burden was assessed with the 22-item Sinonasal Outcome Test (SNOT-22). Ninety patients reporting 0 for all AECRS metrics were considered to have had no AECRS in the prior 12 months. A total of 119 patients reported >3 on at least 1 AECRS metric and were considered as having an exacerbation-prone phenotype. Characteristics associated with patients with an exacerbation-prone phenotype were identified with exploratory regression analysis. Results An exacerbation-prone phenotype was positively associated with comorbid asthma (adjusted odds ratio [ORadj] = 3.68, 95% CI: 1.42-9.50, P = .007) and SNOT-22 (ORadj = 1.06, 95% CI: 1.04-1.09, P < .001). Polyps were negatively associated (ORadj = 0.27, 95% CI: 0.11-0.68, P = .005) with an exacerbation-prone phenotype. SNOT-22 score ≥24 identified patients with an exacerbation-prone phenotype with a sensitivity of 93.3% and a specificity of 57.8%. Having either a SNOT-22 score ≥24 with a nasal subdomain score ≥12 or a SNOT-22 score ≥24 with an ear/facial discomfort subdomain score ≥3 provided >80% sensitivity and specificity for detecting patients prone to exacerbation. Conclusions In total, these results point to a CRS exacerbation-prone phenotype characterized by high sinonasal disease burden with comorbid asthma but interestingly without polyps.

scholarly journals THE EFFECT OF MOTIVATION ON ENGLISH LITERATURE READING TO MEDICAL STUDENTS’ BLOCK EXAMINATION SCORE

2020 ◽  
Vol 9 (2) ◽  
pp. 122
Author(s):  
Dinda Carissa ◽  
Yunia Hastami ◽  
Eti Poncorini Pamungkasari
Keyword(s):  
Medical Students ◽  
English Literature ◽  
Reading Motivation ◽  
Cross Sectional Study ◽  
Average Score ◽  
Cross Sectional ◽  
Literature Reading ◽  
English Reading ◽  
One Year ◽  
Reading Activity

Background: The reading interest rate of Indonesian society is relatively low (approximately 0,001). Meanwhile, during their study, medical students have to read numerous English literatures. Previous research showed that reading activity can be improved by reading motivation. However, studies about Indonesian medical students reading motivation on English literature are still limited. This study aims to assess the effect of students’ English literature reading motivation to the block exam average score.Methods: This was a cross-sectional study conducted in January 2018. We used stratified random sampling, and we found 274 samples that fit with inclusion and exclusion criterias selected. The motivation was assessed using the English literature reading motivation scale, block exam test results were obtained through the academic database. Data were analyzed with multiple linier regression test.Result: Students’ English reading motivation increased the block exam average score of Medical Students. Every increase of one score of motivation significantly increase 0,10 score block exam average (p<0,001). Furthermore, every increase of one year of study can significantly increase 3,53 of block exam average score (p<0,001); R2=18,3 %. English literature reading motivation of medical students UNS is in middle category.Conclusion: English literature reading motivation increase the block exam average score of Medical Students in UNS.

scholarly journals Differentiation of Clinical Patterns Associated With Rhinologic Disease

2020 ◽  
pp. 194589242094170
Author(s):  
Sean M. Parsel ◽  
Charles A. Riley ◽  
Cameron A. Todd ◽  
Andrew J. Thomas ◽  
Edward D. McCoul
Keyword(s):  
Chronic Rhinosinusitis ◽  
Clinical Data ◽  
Nasal Polyposis ◽  
Hierarchical Cluster ◽  
Patient Data ◽  
Diagnostic Efficiency ◽  
Cross Sectional ◽  
Low Frequencies ◽  
Patient Reported ◽  
Snot 22

Background Common rhinologic diagnoses have similar presentations with a varying degree of overlap. Patterns may exist within clinical data that can be useful for early diagnosis and predicting outcomes. Objective To explore the feasibility of artificial intelligence to differentiate patterns in patient data in order to develop clinically-meaningful diagnostic groups. Methods A cross-sectional study of prospectively-acquired patient data at a tertiary rhinology clinic was performed. Data extracted included objective findings on nasal endoscopy, patient reported quality of life (PRQOL) instrument ratings, peripheral eosinophil fraction, and past medical history. Unsupervised non-hierarchical cluster analysis was performed to discover patterns in the data using 22 input variables. Results A total of 545 patients were analyzed after application of inclusion and exclusion criteria yielding 7 unique patient clusters, highly dependent on PRQOL scores and demographics. The clusters were clinically-relevant with distinct characteristics. Chronic rhinosinusitis without nasal polyposis (CRSsNP) was associated with two clusters having low frequencies of asthma and low eosinophil fractions. Chronic rhinosinusitis with nasal polyposis (CRSwNP) was associated with high frequency of asthma, mean (standard deviation [SD]) NOSE scores of 66 (19) and SNOT-22 scores of 41 (15), and high eosinophil fractions. AR was present in multiple clusters. RARS was associated with the youngest population with mean (SD) NOSE score of 54 (23) and SNOT-22 score of 41 (19). Conclusion Broader consideration of initially available clinical data may improve diagnostic efficiency for rhinologic conditions without ancillary studies, using computer-driven algorithms. PRQOL scores and demographic information appeared to be useful adjuncts, with associations to diagnoses in this pilot study.

scholarly journals Evaluation of Cognitive Functions of Individuals Older Than 65 With Diagnosis of Diabetes

2018 ◽  
Vol 34 (3) ◽  
pp. 171-175
Author(s):  
Serap Gokce ◽  
Canan Demir Barutcu
Keyword(s):  
Risk Factor ◽  
Cognitive Function ◽  
Cognitive Functions ◽  
Health Professionals ◽  
Cognitive Assessment ◽  
University Hospital ◽  
Average Score ◽  
Diabetic Patients ◽  
Cross Sectional

This study was conducted in order to examine the level of cognitive function of individuals ≥65 years of age with diabetes. The cross-sectional descriptive design was used. The research was carried out in the diabetes polyclinic of a university hospital between June 2016 and January 2018. The study sample consisted of 91 patients. Data were collected with the scale of Montreal Cognitive Assessment (MoCA). The average score of the patients in the MoCA Scale was found to be 19.61 ± 1.70 (min: 15, max: 26). Diabetes is a risk factor for cognitive dysfunction for individuals above 65 years of age. Health professionals regularly monitor the cognitive functions of diabetic patients and use the MoCA scale in these follow-up and plan training and counseling initiatives according to their needs.

scholarly journals Exposición a factores psicosociales laborales y sintomatología de estrés en trabajadores peruanos.//Exposure to occupational psychosocial factors and stress symptomatology in Peruvian workers.

Ciencia Unemi ◽  
2019 ◽  
Vol 12 (29) ◽  
pp. 1-8
Author(s):  
Manuel Pando-Moreno ◽  
Santiago Gascón-Santos ◽  
Walter Varillas-Vilches ◽  
Carolina Aranda-Beltrán
Keyword(s):  
Risk Factor ◽  
Psychosocial Factors ◽  
Psychosocial Factor ◽  
Emotional Symptoms ◽  
Cross Sectional ◽  
Active Population ◽  
Formal Economy ◽  
Para Determinar ◽  
Related Stress ◽  
Labor Requirements

El estrés laboral es una problemática constante,  presente en los contextos laborales que afecta el desarrollo del trabajador en las esferas fisiológicas, comportamental, intelectual y psicoemocional. Existe evidencia del origen laboral del estrés, pero se requieren mayores estudios para determinar el factor psicosocial que incide en cada dimensión del estrés. El objetivo de la investigación es determinar el grado de riesgo de diversos factores psicosociales para cada tipo de síntomas de estrés. Se realizó un estudio transversal, descriptivo, con una muestra de Población Económicamente Activa de 542 trabajadores peruanos, todos pertenecientes a la economía formal con diversos tipos de puestos de trabajo.  Los factores psicosociales con mayor exposición negativa fueron las “Exigencias Laborales”, el “Contenido y características de la tarea” y la “Carga de Trabajo”. Los siete factores psicosociales estudiados fueron consistentemente factor de riesgo para los síntomas fisiológicos e intelectuales; en ningún caso se mostraron como factor de riesgo para los síntomas psicoemocionales del estrés, y para los síntomas comportamentales solo el factor de “Papel laboral y desarrollo de la carrera” calificó como factor: de riesgo.AbstractWork-related stress is a constant problem that affects the development of the worker in the physiological, behavioral, intellectual and psycho-emotional spheres. There is evidence of the occupational origins of stress, but further studies are required to determine the psychosocial factor that affects each dimension of the stress. The objective of this research is to determine the degree of risk of various psychosocial factors for each type of stress symptoms. A cross-sectional, descriptive study was carried out, with a sample of 542 Economically Active Population of Peruvian workers, all belonging to the formal economy with different types of jobs. The psychosocial factors with greater negative exposure were the "Labor Requirements", "Content and characteristics of the task" and the "Workload". The seven psychosocial factors studied were consistently a risk factor for physiological and intellectuals symptoms; in no case they were showed to be a risk factor for the psycho-emotional symptoms of stress. The factor of "Work role and development of the career" was qualified as a risk factor only for behavioral symptoms.

Association between the use of electronic cigarettes and the prevalence of chronic rhinosinusitis and allergic rhinitis: a nationwide cross-sectional study

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
M.-S. Rha ◽  
H.-J. Cho ◽  
J.-H. Yoon ◽  
C.-H. Kim
Keyword(s):  
Allergic Rhinitis ◽  
Chronic Rhinosinusitis ◽  
Electronic Cigarettes ◽  
Adult Population ◽  
Upper Airway ◽  
Airway Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
High Prevalence

Background: Whether the use of electronic cigarettes (ECs) is associated with upper airway diseases, including chronic rhinosinusitis (CRS) and allergic rhinitis (AR), remains unclear. Methods: We analyzed data from the nationwide cross-sectional surveys: the Korea National Health and Nutrition Examination Survey VI (2013–2015), VII (2016–2018), and VIII (2019). Logistic regression analysis was performed to assess the association between EC use and CRS or AR. Results: Among a total of 38,413 participants, 6.4% were former EC users and 2.5% were current EC users. Former EC users and current EC showed a significantly increased OR for CRS or AR compared with never EC users. In the subgroup analysis, the “current CC (conventional cigarette)-current EC” and the “current CC-formal EC” group had a significantly higher OR for CRS or AR than the “current CC-never EC” group. In addition, former CC smokers who currently use ECs showed a significantly higher OR for AR than former CC smokers without EC use. Conclusions: EC use is significantly associated with a high prevalence of CRS and AR in the adult population. These results indicate that the use of ECs may increase the risk of upper airway disease.

scholarly journals Low Frequency Ultrasound in Chronic Rhinosinusitis with Nasal Polyposis and Recovery after Endoscopic Sinus Surgery: A Randomized Controlled Trial

2017 ◽  
Vol 32 (1) ◽  
pp. 6-13
Author(s):  
Roderick B. De Castro ◽  
Michelle Angelica B. Cruz-Daylo ◽  
Monique Lucia A. Jardin
Keyword(s):  
Chronic Rhinosinusitis ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyposis ◽  
Low Frequency ◽  
Sinus Surgery ◽  
Endoscopic Appearance ◽  
Treatment Groups ◽  
Low Frequency Ultrasound ◽  
Snot 22 ◽  
Frequency Ultrasound

Objective: The study aimed to determine the role of low frequency ultrasound in patients with Chronic Rhinosinusitis with Nasal Polyposis (CRS-NP) and recovery after Endoscopic Sinus Surgery (ESS) using Sino Nasal Outcome Test 22 (SNOT-22) questionnaires, modified Lund MacKay endoscopic appearance, and histopathologic examination. Methods: Study design: Single Blinded Randomized Controlled Trial Setting: Tertiary government hospital Subjects: 42 adult Filipinos aged 19 to 76 years-old diagnosed with Chronic Rhinosinusitis with grade 2 and 3 Nasal Polyposis and failure of maximal medical management (3-month course of antibiotics, nasal douche, topical steroids and other modalities) between June 2013 to June 2015 were randomized into two groups of 21 participants each-- the ultrasound-treated group and control group. Specimens (nasal polyps) from both groups were obtained and processed with Hematoxylin-Eosin (H&E) and gram staining. Specimens from the ultrasound-treated group received low frequency ultrasound (1 MHz, 1.0 watt/cm2, 20% pulsed mode, for 5 minutes at 370C) post-extraction and prior to staining. In phase II, the ultrasound group also received the same ultrasound treatment while the control group underwent ultrasound at 0 MHz frequency, 0 watt/cm2, both twice a week for 3 weeks, beginning one (1) week post operatively. Both groups accomplished SNOT-22 forms and were evaluated via modified Lund MacKay endoscopic appearance at 1 week (week 0 of treatment), 2 weeks, 3 weeks, and 1 month post operatively (week 3 of treatment). Results: Paired T-test showed a statistically significant difference between control and treatment groups in epithelial thickness with a p-value of 2.29E-10 (average of 73.34um for controls and 31.1um for the treatment group) at 95% confidence interval. The inflammatory cell count also differed significantly between control and treatment groups (average 293.85 and 29.65 inflammatory cells per high-power field in 10 random microscopic fields, respectively), p-value of 1.05E-17 on paired T-test; CI 95%.  In phase II of the study, SNOT-22 results showed significant differences in improvement of symptoms in ultrasound-treated patients after Endoscopic Sinus Surgery (weekly mean scores of 38.05, 21, 11.3, and 10.45) and in modified Lund Mackay endoscopic appearance scores (weekly mean scores of 7.88, 4.35, 3.02, 2.08). Two-way analysis of variance showed significant differences between control and treatment groups for both SNOT-22 (p = 1.07E-80; 9.71E-119; CI 95%) and modified Lund Mackay endoscopic appearance scores (p = 3.89E-60; 1.85E-95; CI 95%). Conclusion: Low frequency therapeutic ultrasound demonstrated possible efficacy as an agent in disrupting epithelial architecture in patients with CRS-NP as well as in symptom improvement after endoscopic sinus surgery patients based on histopathologic evaluation, SNOT-22 and modified Lund MacKay endoscopic appearance scores. Low frequency ultrasound may be an adjuvant to conventional medical treatment in CRS-NP. Keywords: Biofilm, Sinusitis, Nasal Polyps, Chronic disease, Ultrasonic therapy  

Patient-reported signs of dampness at home may be a risk factor for chronic rhinosinusitis: A cross-sectional study

2017 ◽  
Vol 47 (11) ◽  
pp. 1383-1389 ◽  
Author(s):  
C. Ahlroth Pind ◽  
M. Gunnbjörnsdottír ◽  
A. Bjerg ◽  
B. Järvholm ◽  
B. Lundbäck ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chronic Rhinosinusitis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Patient Reported ◽  
At Home

Effect of Endoscopic Sinus Surgery on Bronchiectasis Patients With Chronic Rhinosinusitis

2018 ◽  
Vol 32 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Jesada Kanjanaumporn ◽  
Peter H. Hwang
Keyword(s):  
Pulmonary Function ◽  
Chronic Rhinosinusitis ◽  
Endoscopic Sinus Surgery ◽  
Pulmonary Function Tests ◽  
Pearson Correlation ◽  
Airway Disease ◽  
Forced Expiratory Volume ◽  
Sinus Surgery ◽  
Post Operation ◽  
Snot 22

Background The concept of unified airway disease has linked bronchiectasis with chronic rhinosinusitis (CRS), much in the same way as in asthma and CRS. Although the outcomes of endoscopic sinus surgery (ESS) on comorbid asthma have been relatively well studied, the outcomes of ESS on comorbid bronchiectasis have rarely been examined. Objective We sought to determine sinonasal and pulmonary clinical outcomes of ESS in bronchiectasis patients with CRS. Method We reviewed all bronchiectasis patients who had ESS for CRS at our institution from 2006 to present. The sinonasal outcome test 22 (SNOT-22) was administered preoperatively and at 3 months, 1 year, and 3 years postoperatively. Pulmonary function tests (PFTs) were measured preoperatively and at 6 months and 1 year post operation to assess the forced expiratory volume in 1 s (FEV1), forced viral capacity (FVC), and FEV1/FVC values. Paired t test and Pearson correlation were used to compare pre- and postsurgical results. Results A total of 141 bronchiectasis patients who had ESS for CRS were studied. The most common cause of bronchiectasis was cystic fibrosis (CF) (42.55%). SNOT-22 scores improved at 3 months post operation and were maintained at 1 year and 3 years post operation ( P < .001). All SNOT sub-domains showed a significant improvement after surgery ( P < .01). However, PFTs did not change at 6 months post operation and 1 year post operation ( P > .05). There were significant differences in the outcomes in CF versus non-CF patients ( P < .05) but not by sex or age. Conclusion ESS is effective in improving long-term sinonasal outcomes in bronchiectasis patients with CRS. However, ESS does not appear to improve the pulmonary function.

Sign in / Sign up

Export Citation Format

Share Document