Metastasizing Auricular Basal Cell Carcinoma

1980 ◽  
Vol 88 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Richard C. Bryarly ◽  
Stephen R. Veach ◽  
Alan D. Kornblut
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Basal Cell ◽  
Radical Surgery ◽  
Palliative Therapy ◽  
Basal Cell Carcinomas ◽  
Neck Area ◽  
Common Skin

Basal cell carcinoma represents the most common skin cancer and involves the head and neck area in 80% to 85% of all patients treated. Despite their frequent occurrence, metastatic spread from these tumors is rare. This paper presents a case of a patient who had a metastasizing basal cell carcinoma. Despite control of primary disease by radical surgery and adjunctive irradiation, bony metastasis was found within nine months of therapy. Palliative therapy was given, but the patient died five months later. The pathophysiology of the metastasizing basal cell carcinomas is described, and a rationale for therapy presented.

Orthovoltage X-rays for Postoperative Treatment of Resected Basal Cell Carcinoma in the Head and Neck Area

2016 ◽  
Vol 21 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Charlotte W. Duinkerken ◽  
Peter J.F.M. Lohuis ◽  
Marianne B. Crijns ◽  
Arash Navran ◽  
Rick L.M. Haas ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Local Control ◽  
Basal Cell ◽  
Postoperative Radiotherapy ◽  
Local Control Rate ◽  
X Rays ◽  
Basal Cell Carcinomas ◽  
Neck Area

Background: Surgery is the golden standard for treating basal cell carcinomas. In case of positive tumor margins or recurrent disease, postoperative adjuvant or salvaging therapy is suggested to achieve good local control. Objective: To retrospectively report on local control and toxicity of postoperative radiotherapy by means of orthovoltage X-rays for residual or recurrent basal cell carcinoma after surgery in the head and neck area. Methods: Sixty-six surgically resected residual or recurrent basal cell carcinomas of the head and neck region were irradiated postoperatively by means of orthovoltage X-rays at the Netherlands Cancer Institute between January 2000 and February 2015. Results: After a median follow-up duration of 30.5 months, only 5 recurrences were reported. The 5-year local control rates at 1, 3, and 5 years were 100%, 87%, and 87%, respectively. The 5-year local control rate was 92% for immediate postoperative radiotherapy of incompletely resected basal cell carcinomas, 90% for recurrences after 1 previously performed excision, and 71% for multiple recurrences, namely, a history of more than 1 excision ( P = .437). Acute toxicity healed spontaneously within 3 months. Late toxicities were mild. Conclusion: Radiotherapy by means of orthovoltage X-ray is an excellent alternative for re-excision in case of incompletely resected or recurrent basal cell carcinomas that are at risk of serious functional and cosmetic impairments after re-excision, with a 5-year local control rate of 87% and a low toxicity profile.

Geographic Pathology of Skin Cancer

1999 ◽  
Vol 3 (3) ◽  
pp. 120-122
Author(s):  
Robert Jackson
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Basal Cell ◽  
Sun Exposure

Background: The development of knowledge concerning the role of sun exposure in causing skin cancer has been a gradual one. Objective: This article reviews the article by Urbach who used manikin coated with an ultraviolet dosimeter to see exactly where on the head and neck the exposure was greatest. Conclusion: Urbach showed that the areas of greatest sun exposure on his manikins corresponded with the location of 95% of squamous cell carcinoma and 66% of basal cell carcinoma. He also clearly showed the importance of scattered sky and reflected radiation.

Basal Cell Carcinoma in a 12-Year-Old Boy

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 460-463
Author(s):  
Jody Comstock ◽  
Ronald C. Hansen ◽  
Antoinette Korc
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Ultraviolet B ◽  
Basal Cell Carcinomas ◽  
Common Skin ◽  
The Face ◽  
X Irradiation ◽  
Nevus Sebaceus ◽  
White Adults

Basal cell carcinomas are common skin tumors occurring in white adults that are mainly attributable to ultraviolet-B exposure.1 They grow slowly, invade locally, and rarely metastasize.2 Basal cell carcinomas appear most frequently on the head, neck, and upper extremities. The majority occur on the face and the relative risk for recurrent tumor is high in certain sites, especially the nose.3 It is uncommon to see actinically induced basal cell carcinomas in children. There are well documented associations of basal cell carcinomas in children with the nevoid basal cell carcinoma syndrome, xeroderma pigmentosum, nevus sebaceus of Jadassohn, preceding exposure to x-irradiation, or preceding scar from a burn or trauma.4-10

scholarly journals Axillary basal cell carcinoma : New case report

2020 ◽  
Vol 3 (4) ◽  
pp. 01-03
Author(s):  
Mounia Bennani
Keyword(s):  
Case Report ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Systematic Study ◽  
Perianal Area ◽  
Japanese Study ◽  
Common Skin ◽  
Rare Location

Basal cell carcinoma (BCC) is the most common skin cancer, but significant differences exist in its incidence in the various anatomical locations (1) Unusual sites include the axillae, breasts, perianal area, genitalia, palms, and soles (2) the axilla is one of the most sun-protected body sites and represents a rare location at which BCC develops (3), up to 2014, 70 cases of axillary BCC were reported in 69 patients (4) then in 2017, 6 new cases were reported in a Japanese study out of a total of 333 CBC (5), probably the real incidence is underestimated because no systematic study of axillary BCC has generally been conducted (3)

scholarly journals Basal Cell Carcinoma Destruction by a Concentrate of Proteolytic Enzymes Enriched in Bromelain: A Preliminary Report

2021 ◽  
Vol 15 (1) ◽  
pp. 39-44
Author(s):  
Lior Rosenberg ◽  
Adam J Singer ◽  
Yaron Shoham
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Proteolytic Enzymes ◽  
Proof Of Concept ◽  
Future Studies ◽  
Basal Cell Carcinomas ◽  
Common Skin ◽  
The Face ◽  
Potential Use

Objectives: Basal Cell Carcinoma (BCC) is the most common skin cancer generally treated by a variety of surgical and non-surgical destructive therapies. A Concentrate of Proteolytic Enzymes Enriched in Bromelain (CPEEB) derived from the stems of pineapples is approved for use for debriding deep burns. Prior studies suggest that bromelain also has anti-tumor effects. We describe our preliminary off-label treatment experience using topical CPEEB for the destruction of six BCCs in three patients. Methods: CPEEB was self-applied by three patients on six different Morphea, nodular, and superficially invasive BCCs. The CPEEB was applied as a thin layer prior to bedtime and left for a period of 9-12 hours. The wound was then covered with a petrolatum-based ointment for the next 24 hours. Application of the CPEEB was repeated up to 5 times over the course of 10 days, during which the patients were monitored daily and reevaluated by a board-certified plastic surgeon. If necessary, the CPEEB was reapplied up to five additional times over the next 10-day period. If necessary, any remaining lesion was surgically excised (MOHS surgery). The patients were then followed for up to 1 year. Results: Six BCCs located on the face, neck, and extremities were self-treated by three patients with 2-6 CPEEB applications. All of the BCCs were completely removed after the CPEEB application. CPEEB application was associated with local irritation and mild itching pain which resolved untreated within hours. In one patient, two of the lesion’s sites were surgically excised after 6 months with no tumor cells noted on histopathology. None of the BCCs recurred over the next 1 year. Conclusion: Our preliminary findings are a proof-of-concept that a concentrate of proteolytic enzymes enriched in bromelain may be a safe and effective destructive treatment for basal cell carcinomas. Future studies on larger groups of BCC patients are necessary in order to elucidate the potential use of CPEEB for this indication.

Epidemiology of basal cell carcinoma and squamous cell carcinoma of the pinna

2001 ◽  
Vol 115 (2) ◽  
pp. 85-86 ◽  
Author(s):  
Ijaz Ahmad ◽  
A. R. Das Gupta
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Area ◽  
Neck Area ◽  
Diagnosis Of Cancer ◽  
Overall Ratio

This is a retrospective study designed to compare the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in the head and neck skin area with special reference to the pinna.The results showed 426 patients had 460 cutaneous malignancies in the head and neck area, managed by four specialities (ENT, Dermatology, General Surgery and GPs) over the period 1994–99. The lesions comprised 375 (80.47 per cent) BCC and 85 (18.47 per cent) SCC. In cases of BCC the facial areas were commonly involved (88 per cent), whilst SCC was almost equally distributed between the most (face, forehead and nose) and least exposed areas (pinna and scalp). The overall ratio of BCC to SCC remained four to one in the head and neck area. In 41 patients with 51 lesions over the pinna there were 29 (56.8 per cent) BCC and 22 (43.1 per cent) SCC hence the ratio was 1.3 to 1 for this site.We conclude that in the case of a suspicious lesion over the pinna, the risk of SCC is comparatively much higher. With increasing awareness of early and quick diagnosis of cancer cases, it is recommended that these patients should be referred urgently to prevent the significant morbidity associated with invasive SCC.

scholarly journals Modified Rhomboid Flap for Reconstruction of Defect of Cheek after Excision of Basal Cell Carcinoma

2016 ◽  
Vol 6 (2) ◽  
pp. 154-156
Author(s):  
Sunil Sidana ◽  
Adil Gandevivala ◽  
Dinesh H Shah ◽  
Akram Khan
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Laser Surgery ◽  
Human Face ◽  
Skin Malignancy ◽  
Basal Cell Carcinomas ◽  
Common Skin ◽  
Rhomboid Flap ◽  
Topical Medications

ABSTRACT The cheek is a very important part of the human face because it is the largest part and is essential in terms of both esthetics and functionality. Basal cell carcinomas (BCCs) are most common skin malignancy found in Caucasians and rarely in Asians. Treatment can range from topical medications, curettage, Mohs micrography, cryosurgery, laser surgery and excision. Defect left after excision can be cosmetically disfiguring. Options for reconstruction after excision of the lesion are skin graft and local flaps. We present a case of BCC of the cheek which was reconstructed with modified rhomboid flap. How to cite this article Gandevivala A, Shah DH, Sidana S, Khan A. Modified Rhomboid Flap for Reconstruction of Defect of Cheek after Excision of Basal Cell Carcinoma. J Contemp Dent 2016;6(2):154-156.

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