scholarly journals Clinical effectiveness and potential long-term benefits of high-intensity focused ultrasound therapy for patients with adenomyosis

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052097649
Author(s):  
Wei Li ◽  
Jiayu Mao ◽  
Yang Liu ◽  
Ying Zhu ◽  
Xiaojing Li ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Clinical Effectiveness ◽  
Treatment Method ◽  
Mean Difference ◽  
High Intensity Focused Ultrasound ◽  
Noninvasive Treatment ◽  
Numerical Rating

Objectives Adenomyosis is a common and refractory disease in gynecology. Preserving the uterus during treatment for adenomyosis remains a problem. High-intensity focused ultrasound (HIFU) is widely used in treatment of solid tumors. This study aimed to analyze patients with adenomyosis who were treated by HIFU and to preliminarily examine the characteristics of patients who are more suitable for HIFU to treat adenomyosis with reliable efficacy. Methods Over 2 years, 67 women who were diagnosed with adenomyosis and treated with HIFU at our gynecology department were included in this study. We investigated outcomes of their symptoms (dysmenorrhea and hypermenorrhea) and the volume of their uterine lesions. We also compared the patients’ clinical profiles. Results The women had a mean follow-up duration of 11.6 ± 0.46 months. In the numerical rating scale, used to assess the degree of dysmenorrhea, the score was significantly lower (mean difference: −1.94, 95% confidence interval: −2.704 to −1.176) 3 months after HIFU treatment compared with before treatment, then it remained stable for 3 to 12 months. Hypermenorrhea was reduced to a certain degree, with a mean difference of −0.54 (−1.01–0.02). Conclusions HIFU is a new noninvasive treatment method for adenomyosis that may help relieve dysmenorrhea.

Modeling and Simulation of High-Intensity Focused Ultrasound Therapy for Breast Cancer

2013 ◽  
Author(s):  
Kohei Okita ◽  
Ryuta Narumi ◽  
Takashi Azuma ◽  
Shu Takagi ◽  
Yoichiro Matsumoto
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Treatment Time ◽  
The Body ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Therapy ◽  
Tumor Treatment ◽  
Therapeutic Application ◽  
Noninvasive Treatment ◽  
Blood Brain Barrier Opening

Therapeutic application of ultrasound is of interest for a tumor treatment, thrombolysis, drag delivery, blood-brain barrier opening and so on. High-intensity focused ultrasound (HIFU) therapy has been developed as the noninvasive treatment deep cancers in particular. Issues as the defocusing and distortion of ultrasound in the body and the long treatment time in current HIFU should be resolved quickly. Numerical simulation is required for the early development of the advance HIFU system.

scholarly journals The acute effects of high-intensity jack-knife stretching on the flexibility of the hamstrings

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kosuke Takeuchi ◽  
Kazunori Akizuki ◽  
Masatoshi Nakamura
Keyword(s):  
High Intensity ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Knee Extension ◽  
Acute Effects ◽  
Safe Method ◽  
Passive Torque ◽  
Before And After ◽  
Numerical Rating ◽  
Healthy Participants

AbstractThe purpose of the present study was to examine the acute effects of high-intensity jack-knife stretching for 60 s on flexibility of the hamstrings. Twelve healthy participants underwent jack-knife stretching for 60 s (3 repetitions of 20 s stretching with 30 s intervals) at two different intensities based on the point of discomfort (POD and PODmax). To examine any change in flexibility, knee extension range of motion (ROM), passive torque at end ROM, and muscle–tendon unit stiffness were measured before and after stretching. To evaluate hamstrings pain, a numerical rating scale (NRS) was described. The knee extension ROM (p < 0.01) and passive torque at end ROM (p < 0.05) were significantly increased at both intensities. The muscle–tendon unit stiffness was significantly decreased in PODmax intensity (p < 0.01), but there was no change in POD intensity (p = 0.18). The median values of NRS during the stretching were 0 and 6–7 in POD and PODmax intensity, respectively, although it was 0 immediately after the stretching protocol in both intensities. These data suggested that high-intensity jack-knife stretching is an effective and safe method to decrease muscle–tendon unit stiffness of the hamstrings.

High-intensity focused ultrasound ablation for treatment of chemotherapy-induced thrombocytopenia and hypersplenism.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 3082-3082
Author(s):  
Min Yuan ◽  
Qing Xu ◽  
Zhongzheng Zhu ◽  
Wei Mao ◽  
Xianling Guo ◽  
...  
Keyword(s):  
Platelet Count ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Treatment ◽  
Noninvasive Treatment ◽  
Ablation Volume ◽  
Ultrasound Ablation ◽  
Focused Ultrasound Ablation

3082 Background: Chemotherapy-induced thrombocytopenia (CIT) contributes to treatment dose delay and/or modification, often resulting in poorer survival and disease progression. Compared with partial splenic embolization (PSE) and drugs, high-intensity focused ultrasound has the advantages as following: (1) it is a noninvasive treatment modality with potentially fewer adverse effects and complications; (2) the hospital stay and recovery time after treatment are short; (3) its cost is relatively low compared to surgery. The purpose of this work was to preliminarily investigate the efficacy and safety of high intensity focused ultrasound treatment of chemotherapy-induced thrombocytopenia (CIT) and hypersplenism. Methods: 26 patients with chemotherapy-induced thrombocytopenia and hypersplenism (15 male and 11 female; median age, 56 years; range, 51-66 years) were treated with ultrasound guided high-intensity focused ultrasound. Complications were recorded. Laboratory examination and magnetic resonance imaging were used to evaluate the efficacy. The spleen volume and ablation volume rate of the spleen were calculated by MRI after treatment. They were followed closely for at least 6 months. Results: After high-intensity focused ultrasound treatment, the MRI showed that the ablation area had turned into a non-perfused volume, the mean percent spleen ablation volume was 18.76% ± 6.1% (range, 11.17%-32.34%). After 6 months of HIFU ablation, the ablated area shrank evidently; the sunken spleen formed a lobulated shape and the splenic volume decreased. The platelet count increased 3-7 days after treatment and remained for 1-2weeks higher than baseline (53.33 ± 15.80 × 109/L). The white blood cell count and platelet count of the patients were substantially improved during the follow-up period. No substantial difference was observed in RBC counts between baseline and after treatment. In addition, symptoms such as epistaxis and gingival bleeding were ameliorated or even eliminated, and the quality of life was improved. Follow-up imaging showed a nonperfused volume in the spleen. Conclusions: For the first time to our knowledge, high-intensity focused ultrasound ablation was used to treat Chemotherapy-induced thrombocytopenia (CIT) and hypersplenism. High-intensity focused ultrasound ablation of the spleen may cause damage to a certain volume of the spleen parenchyma to achieve the purpose of hypersplenism treatment. High intensity focused ultrasound may be an effective and safe alternative for treatment of CIT and hypersplenism.

High-intensity focused ultrasound: Noninvasive treatment for local unresectable recurrence of osteosarcoma

2015 ◽  
Vol 24 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Wenxi Yu ◽  
Lina Tang ◽  
Feng Lin ◽  
Yang Yao ◽  
Zan Shen ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Noninvasive Treatment

scholarly journals EFFECT OF NADIFLOXACIN PHONOPHORESIS AND PULSED ULTRASOUND IN SUBJECTS WITH ACUTE SINUSITIS- A RANDOMIZED CLINICAL TRIAL

2020 ◽  
Vol 8 (9) ◽  
pp. 1179-1182
Author(s):  
Anil Rachappa Muragod ◽  
◽  
Anil S. Harugop ◽  
Kirti Khemlapure ◽  
Krupa Varahmurty ◽  
...  
Keyword(s):  
Rating Scale ◽  
Numerical Rating Scale ◽  
Mean Difference ◽  
Acute Sinusitis ◽  
P Value ◽  
Pulsed Ultrasound ◽  
Before And After ◽  
Numerical Rating ◽  
Group A ◽  
Group B

Aim: To find effectiveness of nadifloxacin phonophoresis over pulsed ultrasound in acute sinusitis subjects. Methods: Study was approved by Institutional Ethical Committee of KAHER Institute of Physiotherapy, Belagavi.40subjects with acute sinusitis were divided randomly into group A, treated with nadifloxacin phonophoresis and group B, treated with pulsed ultrasound. Subjects were assessed using Sinusitis Symptom Score, Numerical Rating scale and Sino-nasal outcome test-22 before and after 4 days of intervention. Result: For sinusitis symptom measure within the groups, mean difference were 6.16±1.97 and 6.27±1.8 with p-value of 0.001 for both the groups which was significant. For between the groups, p-value was 0.700 which was not significant. For numerical rating scale within the groups, mean difference was 0.37±0.14. and 0.27±0.08 with p-value of 0.001 for both the groups which was significant. For between the groups, p-value of 0.014 which was significant. For Sino nasal outcome test within the groups, mean difference was 16.33±9.55 and 7.50±1.85 with p-value of 0.001 for both the groups which was significant. For between the groups, p-value was 0.001 which was significant. Conclusion: Nadifloxacin phonophoresis was more effective than pulsed ultrasound in acute sinusitis.

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