scholarly journals Adenocarcinomas of the Intestine Induced in Syrian Hamsters by N-methyl-N-nitrosourea

1969 ◽  
Vol 6 (5) ◽  
pp. 403-412
Author(s):  
Katherine McD. Herrold
Keyword(s):  
Small Intestine ◽  
Cytological Change ◽  
Histological Changes ◽  
Syrian Hamsters ◽  
Histological Types ◽  
Absorptive Cells ◽  
Cytological Features

The adenocarcinomas of the intestine induced in Syrian hamsters by N-methyl-N-nitrosourea (NMU) were of two histological types, superficial and intestinal. These types had distinctive characteristics regarding pattern, cytological features, secretion of mucus, and mode of growth. The histological changes induced by NMU in the mucosa of the small intestine differed from what has been described in enzootic intestinal adenocarcinoma and proliferative ileitis of Syrian hamsters. NMU produced alteration in the villous architecture and cytological change in the absorptive cells. There was marked shortening of the villi and reduced thickness of the mucosa. The villous absorptive cells were large and cuboidal with centrally placed nuclei.

Endocytosis by absorptive cells in the middle segment of the suckling rat small intestine

2002 ◽  
Vol 77 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Ryoko Baba ◽  
Mamoru Fujita ◽  
Chen En Tein ◽  
Masayuki Miyoshi
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
Middle Segment ◽  
Absorptive Cells

Small Intestine: Absorptive Cells

2010 ◽  
pp. 224-225
Author(s):  
Margit Pavelka ◽  
Jürgen Roth
Keyword(s):  
Small Intestine ◽  
Absorptive Cells

Demonstration of microtubules in the terminal web of mature absorptive cells from the small intestine of the rat

1987 ◽  
Vol 248 (3) ◽  
pp. 709-711 ◽  
Author(s):  
SusanJ. Hagen ◽  
CarolH. Allan ◽  
JerryS. Trier
Keyword(s):  
Small Intestine ◽  
Terminal Web ◽  
Absorptive Cells

Biochemical and histological changes in the small intestine of mice with dextran sulfate sodium colitis

2011 ◽  
Vol 226 (12) ◽  
pp. 3219-3224 ◽  
Author(s):  
Roger Yazbeck ◽  
Gordon S. Howarth ◽  
Ross N. Butler ◽  
Mark S. Geier ◽  
Catherine A. Abbott
Keyword(s):  
Small Intestine ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Histological Changes

scholarly journals BRUSH BORDER DEVELOPMENT IN THE INTESTINAL ABSORPTIVE CELLS OF XENOPUS DURING METAMORPHOSIS

1970 ◽  
Vol 44 (1) ◽  
pp. 151-171 ◽  
Author(s):  
Mary A. Bonneville ◽  
Melvyn Weinstock
Keyword(s):  
Electron Microscopy ◽  
Small Intestine ◽  
Brush Border ◽  
Apical Membrane ◽  
Surface Membrane ◽  
Apical Surface ◽  
Absorptive Cells ◽  
Golgi Region ◽  
Macromolecular Architecture

The differentiation of the brush border which makes up the apical free surface of intestinal absorptive cells has been studied by electron microscopy. Specimens of Xenopus small intestine were fixed at various stages during metamorphosis, the time when a new intestinal epithelium forms. The interpretation of details described herein emphasizes the role of "surface-forming" vesicles. These vesicles are thought to provide membrane both for the initial expansion of the apical surface and for the later elongation of the microvilli. The latter are believed to be "molded" around filamentous cores that appear early in differentiation. The cores are attached to the apical membrane and extend vertically into the supranuclear cytoplasm. This interpretation rests chiefly on (a) the resemblance, both in morphology and in staining properties with colloidal thorium, between the membrane that limits the vesicles and that which limits the microvilli and (b) the distribution and time of appearance of the vesicles with respect to development of the microvilli. According to this view, the specific properties of surface membrane reside in preformed units that arise within the supranuclear cytoplasm. This morphogenetic process probably involves participation of the Golgi region as the site where the complex macromolecular architecture of the cell surface is assembled.

scholarly journals Efficacy of oryzalin and associated histological changes in Cryptosporidium-infected neonatal rats

Parasitology ◽  
2002 ◽  
Vol 125 (2) ◽  
pp. 113-117 ◽  
Author(s):  
A. ARMSON ◽  
K. MENON ◽  
A. O'HARA ◽  
L. M. MACDONALD ◽  
C. M. READ ◽  
...  
Keyword(s):  
Small Intestine ◽  
Single Dose ◽  
Neonatal Rats ◽  
Intestinal Villus ◽  
Histological Changes ◽  
Distal Small Intestine ◽  
Maximum Inhibition

This paper reports the anti-cryptosporidial effects of, and concomitant amelioration of the histological changes in the gut of neonatal rats with intestinal cryptosporidiosis treated with the dinitroaniline, oryzalin. The ED50 was determined to be 7 mg/kg using twice daily doses administered for 3 consecutive days. A maximum inhibition of 85.5% was achieved at 25 mg/kg and this inhibition remained constant despite increasing the oryzalin dose to 200 mg/kg. Cryptosporidiosis significantly decreased the intestinal villus/crypt (VC) ratio by approximately 50% (duodenum = 2.3, jejunum = 2.5 and ileum = 1.7) when compared to uninfected untreated controls (duodenum = 4.3, jejunum = 5.9 and ileum = 4.5). Treatment with oryzalin doubled the VC ratio in the duodenum, jejunum and ileum following doses of 5 mg, 50 mg and 200 mg/kg respectively. Oryzalin concentrations in the small intestine contents and plasma were determined, using HPLC, at 0.5, 1 and 2 h after dosing. The much greater dose required to return VC ratios to normal in the ileum (200 mg/kg) compared to the duodenum (6.25 mg/kg) appeared to reflect the decreased concentration of the drug in the distal small intestine. Concentrations of oryzalin equivalent to the in vitro IC50 were maintained for 2 h in the first half of the small intestine following a single dose of 100 mg/kg.

Ultrastructure of the Intestinal Absorptive Cells of Fed and Fasted Tadpoles

1970 ◽  
Vol 28 ◽  
pp. 86-87
Author(s):  
Robert Giaquinta ◽  
M. A. Hayat
Keyword(s):  
Electron Microscopy ◽  
Small Intestine ◽  
Fine Structure ◽  
Osmium Tetroxide ◽  
Rana Pipiens ◽  
Ultrastructural Changes ◽  
Amphibian Metamorphosis ◽  
Absorptive Cells ◽  
Food Absorption ◽  
Tissue Specimens

The ultrastructural changes that occur in the intestinal absorptive cells during amphibian metamorphosis have been reported (Bonneville, 1963). These changes accompany a change in diet (from an herbivorous to a carnivorous state) during metamorphosis. Little information is available, however, on the ultrastructural changes in the absorptive cells of amphibians in relation to the state of feeding. This report describes the differences in the fine structure of these cells in the tadpole stage of Rana pipiens during periods of food absorption and fasting.Rana pipiens at tadpole stages were fed an herbivorous diet, and after a period of 48 hr, the animal was dissected and segments of the small intestine were collected for electron microscopy. A second group of tadpoles was fasted for 7 days, and segments of the small intestine were collected. The tissue specimens were immersed in phosphate-buffered glutaraldehyde (3%) for 1 hr at 4C and postfixed with phosphate-buffered osmium tetroxide (2%) for 1 hr at 4C.

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