Intraindividual Comparison of two Extracorporeal LDL Apheresis Methods: Lipidfiltration and HELP

2002 ◽  
Vol 25 (12) ◽  
pp. 1180-1188 ◽  
Author(s):  
U. Julius ◽  
W. Metzler ◽  
J. Pietzsch ◽  
T. Faßbender ◽  
R. Klingel
Keyword(s):  
Plasma Volume ◽  
Plasma Proteins ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Plasma Heating ◽  
Hdl Cholesterol ◽  
The Novel ◽  
Ldl Apheresis ◽  
Effective Treatment Option ◽  
Plasma Therapy

Low density lipoprotein (LDL) apheresis is an effective treatment option for patients with severe hypercholesterolemia not adequately responding to diet and drug therapy. Membrane differential filtration (MDF), synonymous with double filtration plasmapheresis (DFPP), here named Lipidfiltration, and heparin-induced extracorporeal LDL-precipitation (HELP) are two of the five methods available for extracorporeal LDL apheresis. In this prospective investigation 6 patients with severe LDL-hypercholesterolemia and CAD were treated in a cross-over design with Lipidfiltration at two stages of technical development and HELP to compare the efficacy of these two LDL apheresis methods with respect to lowering and modifying plasma lipids and rheologically relevant plasma proteins, especially fibrinogen. In total, 44 LDL apheresis sessions were investigated. In weekly intervals, patients were treated with consecutive LDL apheresis sessions with either Lipidfiltration and HELP, treating identical plasma volumes. In one part of the investigation Lipidfiltration was performed with the novel Lipidfilter EC-50, combined with a newly developed blood and plasma therapy machine allowing optimized plasma heating. The results showed that the reduction rates of LDL-cholesterol, lipoprotein(a) and triglycerides were essentially identical for both methods. Also pretreatment levels of total cholesterol, triglycerides, LDL-cholesterol and HDL-cholesterol were not significantly different in both treatment groups. Both methods lead to a significant reduction of serum lipoproteins, especially for LDL-cholesterol, which was decreased by 61.4% with Lipidfiltration (treated plasma volume: 2998 ml) and 61.3% with HELP (treated plasma volume: 3013 ml). With respect to Lipidfiltration LDL-cholesterol reduction was more efficient with the novel Lipidfilter EC-50. Mean pretreatment HDL cholesterol concentrations remained unchanged. Comparing Cascadeflo AC-1770 with the novel Lipidfilter EC-50 reduction rates of HDL-cholesterol (17.4% versus 6.4%) and total protein (17.9% versus 7.8%) were significantly reduced. Lipidfiltration and HELP both resulted in a reduction of plasma viscosity and hemorheologically relevant plasma proteins, like fibrinogen.

scholarly journals Exploring the relation between methylxanthines and plasma lipids in two population-based studies

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
D Petrovic ◽  
M Pruijm ◽  
B Ponte ◽  
D Ackermann ◽  
G Ehret ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
High Performance ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Caffeine Intake ◽  
Liquid Chromatography Tandem Mass ◽  
Beneficial Impact ◽  
Active Substances

Abstract Background Chronic intake of caffeinated beverages might be associated with plasma lipids via disturbed lipid metabolism. Previous investigations have been limited by the use of self-reported caffeine intake instead of measured caffeine, whereas the associations between plasma lipids and other methylxanthines (paraxanthine, theobromine, theophylline) are unknown. Here, we investigated the associations of plasma lipids with caffeine and its metabolites in plasma and urine in two European populations. Methods Individuals were selected from the general population of North Belgium (FLEMENGHO) and Switzerland (SKIPOGH). Total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were measured in plasma using standard enzymatic methods. Plasma and 24h urinary caffeine, paraxanthine, theophylline, and theobromine excretions were measured using ultra-high performance liquid chromatography tandem mass spectrometry. We used mixed models to explore the associations of methylxanthines with plasma lipids while adjusting for major confounders. Results Overall, 1946 FLEMENGHO participants (911 men, age 45.9±15.2 years) and 990 SKIPOGH participants (467 men, age 47.1±17.3 years) were included. Mean plasma total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in FLEMENGHO/SKIPOGH were 5.37/5.06, 3.12/3.12, 1.43/1.50, and 2.4/1.02 mmol/L. In both cohorts, adjusted mean total cholesterol, LDL cholesterol, and HDL cholesterol, increased with quartile of plasma caffeine, with stronger associations in men. Similar positive associations were observed for paraxanthine and theophylline. Similar associations were observed using 24h urine excretions in SKIPOGH. Conclusions Plasma and urinary caffeine, paraxanthine, and theophylline were positively associated with plasma lipids in men, whereas there were fewer meaningful associations in women. The increase in plasma lipids might mitigate the overall beneficial impact of caffeinated beverages on health. Key messages Caffeine constitutes one of the most widely consumed biological active substances. Plasma concentration and urinary excretion of caffeine and its derived metabolites is positively associated with plasma lipids.

scholarly journals An association of ABCG8: rs11887534 polymorphism and HDL-cholesterol response to statin treatment in the Polish population

2021 ◽  
Author(s):  
A. Sałacka ◽  
A. Boroń ◽  
I. Gorący ◽  
I. Hornowska ◽  
K. Safranow ◽  
...  
Keyword(s):  
Genomic Dna ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Hdl Cholesterol ◽  
Statin Treatment ◽  
Peripheral Blood Leukocytes ◽  
Wild Type ◽  
Blood Leukocytes ◽  
Before And After ◽  
Caucasian Patients

Abstract Background Variation in lipid changes in response to statin treatment is associated with genetic polymorphism. Sterolin-1, encoded by ABCG5, and sterolin-2, encoded by ABCG8, together form a sterol transporter. There are some reports indicating association of rs11887534 (ABCG8:c.55G > C) polymorphism with lipid concentrations, both prior to and after statin treatment. The aim of this study was to analyze both baseline plasma lipids and their concentrations in response to statin treatment with regard to ABCG8: rs11887534 polymorphism in Caucasian patients of Polish origin. Methods The study group consisted of 170 consecutive adult out-patients treated with atorvastatin or simvastatin for a minimum of 2 months. Concentrations of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) were measured before and after statin treatment. The ABCG8 polymorphism was identified by mini-sequencing genomic DNA extracted from peripheral blood leukocytes. Results There were no significant differences in regard to ABCG8 variants for baseline TG, TC, LDL-C and HDL-C as well as for TG, TC or LDL-C concentrations after statin treatment. However, patients carrying at least one C allele showed a decrease in post-statin HDL-C concentrations and the absolute and relative changes between post- and pre-statin HDL-C concentrations were negative in contrast to positive values in wild-type homozygotes. Conclusions Our results suggest that the c.55C allele of the ABCG8: rs11887534 polymorphism might be associated with decrease in HDL-cholesterol in response to statin treatment in Polish patients.

scholarly journals Short-term effect of whole milk and milk fermented by Pseudomonas fluorescens on plasma lipids in adult boars

1991 ◽  
Vol 66 (1) ◽  
pp. 129-138 ◽  
Author(s):  
Peter Stoll ◽  
Andreas Gutzwiller ◽  
Martin Jost ◽  
Heiner Schneeberger ◽  
Robert Sieber ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Pseudomonas Fluorescens ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Feeding Frequency ◽  
Short Term ◽  
Whole Milk

The short-term effects of whole milk and milk fermented by Pseudomonas fluorescens, of the amino acid composition of the diet and of feeding frequency on the level of plasma lipids, were investigated in six 1-year-old adult boars. The experimental diets contained equal amounts of protein, carbohydrates, fat and cholesterol. After an adaptation period of 5 d for each experimental treatment, blood was collected at regular intervals during 48 h and plasma levels of cholesterol, triacylglycerol, high-density-lipoprotein (HDL)-cholesterol and low-density-lipoprotein (LDL-cholesterol were examined). All variables except HDL-cholesterol showed distinct diurnal fluctuations, which were substantially influenced by feeding frequency. Variations in the amino acid composition of the experimental diets, which were within a physiological range, had no effect on the level of plasma lipids. Plasma lipid levels were significantly lower when the animals received the diets containing milk instead of the diet without milk: cholesterol, triacylglycerol, and LDL-cholesterol were reduced by 5.6, 5.8 and 10% respectively (pondered means) while HDL-cholesterol remained unaffected. Fermentation of whole milk by P. fluorescens reduced the lipid-lowering effect. Our findings suggest that the intake of diets containing milk results in a lower plasma cholesterol and LDL-cholesterol level than the intake of diets with a similar nutrient content which do not contain milk.

scholarly journals The association of plasma lipids with white blood cell counts: Results from the Multi-Ethnic Study of Atherosclerosis

2018 ◽  
Author(s):  
Yong Chang Lai ◽  
Kevin J. Woollard ◽  
Robyn L. McClelland ◽  
Matthew A. Allison ◽  
Kerry-Anne Rye ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Hdl Cholesterol ◽  
Lipid Lowering ◽  
Total White Blood Cell ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

AbstractBackground and aimsPrevious studies have demonstrated that elevated cholesterol results in increased white blood cell counts in mouse models. However, there is insufficient evidence to support this in humans. We, therefore, investigated the relationship of plasma lipids with white blood cell counts (basophils, eosinophils, monocytes, neutrophils and lymphocytes) in the Multi-Ethnic Study of Atherosclerosis (MESA).MethodsThe analysis included 2873 MESA participants at visit 5 with a complete white blood count and differential analysis. The cross-sectional association of total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride levels with different white blood cell counts was analyzed by multivariable linear regression.ResultsAfter adjusting sociodemographic and confounding factors including red blood cells counts, platelet counts, use of lipid-lowering medication, CVD risk factors and other lipid measures, and multiple testing correction, a 1-SD increment in total cholesterol and LDL cholesterol was associated with 2.8% and 2.3% (both p<0.001) lower total white blood cell counts. The same increment in ln-transformed triglyceride levels was associated with 2.3% higher total white blood cell counts, 2.9% higher lymphocyte counts and 2.7% lower monocyte counts (all p<0.001). HDL cholesterol was not associated with any white blood cell counts. Similar results were obtained after excluding participants taking lipid-lowering medication.ConclusionsWhilst significant associations were observed, the heterogenous and modest nature of the relationships between plasma lipid levels and white blood cell populations make it hard to support the hypothesis that lipids are in the causal pathway for leukogenesis.

Abstract 20310: Cardiovascular Risk Markers in a Large Cohort of Children With Genetically Verified FH Show No Inheritance-Related but LDL Receptor Mutation-Type and Family History of CVD-related Variance

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Ingunn Narverud ◽  
Jeaninen R van Lennep ◽  
Jacob J Christensen ◽  
Jorie Versmissen ◽  
Jon M Gran ◽  
...  
Keyword(s):  
Family History ◽  
Mixed Model ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Receptor Gene ◽  
Ldl Receptor ◽  
Hdl Cholesterol ◽  
Premature Cardiovascular Disease ◽  
History Of ◽  
The Impact

Introduction: Familial hypercholesterolemia (FH) is an autosomal dominant disease caused primarily by mutations in the low density lipoprotein (LDL) receptor gene. FH patients have increased total- and LDL cholesterol leading to accelerated atherosclerosis and premature cardiovascular disease (CVD). In an FH pregnancy the absolute rise in lipid levels are often much higher than in healthy pregnancies, and this maternal hypercholesterolemia may thus contribute to an unfavorable in utero environment potentially increasing susceptibility of adult CVD. Few studies have investigated whether maternal FH is associated with an unfavorable phenotype in offspring compared with paternal FH inheritance. Hypothesis: The aim of the present study was to investigate the impact of maternal vs. paternal FH on pre-treated plasma lipids. In addition, the effect of LDL receptor mutation types and Family history of early CVD in FH children was evaluated Methods: We included 1063 children with FH (0-19 years) in the study. Five-hundred had inherited FH maternally and 563 paternally. Furthermore, 624 children with FH had an LDL receptor negative mutation and 332 of the FH children had an FH grandparent suffering from early CVD whereas the remaining children had an FH grandparent with late or no CVD. Differences were tested for using a random intercept mixed model taking account for between-family variation. Results: Children with maternal FH did not have different levels of total-, LDL- or HDL-cholesterol, triglycerides, apoA1, apoB, lipoprotein (a) compared with children With paternal FH. Moreover, children with LDL receptor negative mutations had higher levels of total- and LDL cholesterol in addition to apoB, and concomitantly lower levels of HDL-cholesterol and apoA-1 than children with other LDL receptor mutations. Finally, children with an FH grandparent with early CVD had significant higher LDL-cholesterol levels than children without. Conclusions: Maternal FH does not lead to a more unfavorable phenotype in untreated FH children. However, both FH children with LDL receptor negative mutation and FH children with early CVD in family had a more unfavorably phenotype. Hence statin treatment should potentially be initialized earlier in this group.

Increased Plasma Levels of Tissue Factor Pathway Inhibitor (TFPI) after n-3 Polyunsaturated Fatty Acids Supplementation in Patients with Chronic Atherosclerotic Disease

1996 ◽  
Vol 75 (03) ◽  
pp. 395-400 ◽  
Author(s):  
Mauro Berrettini ◽  
Pasquale Parise ◽  
Serena Ricotta ◽  
Alfonso Iorio ◽  
Cristina Peirone ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Tissue Factor ◽  
Plasma Levels ◽  
Tissue Factor Pathway Inhibitor ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Hdl Cholesterol ◽  
Factor Vii ◽  
Tissue Factor Pathway

SummaryThis double-blind, randomised, controlled study examined the effect of a daily dosage of 3 g n-3 polyunsaturated fatty acids (n-3 PUFA) on plasma lipids and some haemostatic factors in 40 patients with chronic atherosclerotic diseases. Serum lipids, factor VII, tissue factor pathway inhibitor (TFPI) and prothrombin activation fragment 1+2 (F1+2) were measured at baseline and after 2, 8, and 16-week supplementation of either n-3 PUFA or com oil. Administration of n-3 PUFA promptly lowered serum triglycerides and increased LDL-cholesterol (-32% and +33%, respectively, after 2 weeks of treatment) while a significant increase (+31%) in HDL-cholesterol was documented at the end of the observation period. Treatment with n-3 PUFA induced a progressive significant increase of TFPI plasma levels (+21% after 16 weeks; p = 0.029). TFPI activity was significantly correlated with LDL-cholesterol, and multiple stepwise regression analysis showed that LDL-cholesterol was the most important predictor of TFPI activity. Plasma levels of the inhibitor showed also a very high parallelism in their trend over time (ANOVA model for homogeneity of slopes) with both HDL-cholesterol (p = 0.82) and LDL-cholesterol (p = 0.67). Patients treated with n-PUFA also showed a significant reduction of F1+2 plasma levels (p = 0.016) while no significant changes were detected in plasma factor VII clotting activity. Lipid and haemostatic parameters were not modified at any study time in patients receiving corn oil as placebo. The results of this study confirm the effects of n-3 PUFA administration on plasma lipids and show that in patients with chronic atherosclerotic disease a 16-week supplementation with these compounds induces a small but statistically significant increase of TFPI plasma levels with a parallel down-regulation of the extrinsic pathway of blood coagulation which may be relevant to the antithrombotic activity of fish diet and fish oil derivatives.

scholarly journals FADS and PPARG2 Single Nucleotide Polymorphisms are Associated with Plasma Lipids in 9-Mo-Old Infants

2019 ◽  
Vol 149 (5) ◽  
pp. 708-715 ◽  
Author(s):  
Lotte Lauritzen ◽  
Ingvild D Amundsen ◽  
Camilla T Damsgaard ◽  
Mads V Lind ◽  
Theresia M Schnurr ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Single Nucleotide Polymorphisms ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Hdl Cholesterol ◽  
Potential Effect ◽  
Effect Modification ◽  
Minor Allele ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

ABSTRACT Background Dietary intake of polyunsaturated fatty acids (PUFAs), e.g., linoleic acid and n–3 (ω-3) long-chain PUFAs, has been shown in adults to affect plasma cholesterol and triglycerides (TGs), respectively. Little is known about the effects of PUFAs on plasma lipids in early life. Objective The aim of this study was to explore the associations between plasma concentrations of total, LDL, and HDL cholesterol and TGs in infants and 2 single nucleotide polymorphisms (SNPs) in the fatty acid desaturase genes (FADS) oppositely associated with docosahexaenoic acid (rs1535 and rs174448) and potential effect modification by a functional peroxisome proliferator-activated receptor-γ2 gene variant (PPARG2 Pro12Ala). Methods In 9-mo-old infants (n = 561) from 3 Danish cohorts, we analyzed associations between plasma lipids, erythrocyte PUFAs, and FADS SNPs, and interactions with PPARG2 Pro12Ala genotype, by multiple linear regression. We also examined potential effect modification by breastfeeding, as 46% of the infants were still being breastfed. Results Minor allele carriage of rs174448 was associated with lower total cholesterol (difference: −0.22 mmol/L; 95% CI: −0.37, −0.06 mmol/L; P = 0.006) and LDL cholesterol (difference: −0.15 mmol/L; 95% CI: −0.29, −0.01 mmol/L; P = 0.035), but no associations were observed with TGs or for rs1535. Minor allele carriage of both FADS SNPs was associated with 1 SD lower HDL cholesterol, but only in currently breastfed infants (rs174448 × breastfeeding, P = 0.080; rs1535 × breastfeeding, P = 0.030) and PPARG2 minor allele carriers (rs174448 × PPARG2, P = 0.001; rs1535 × PPARG2, P = 0.004). Erythrocyte arachidonic acid and eicosapentaenoic acid were inversely associated with LDL cholesterol [estimated effect (β): −0.3 mmol/L; 95% CI: −0.06, −0.00 mmol/L per percentage of fatty acids (FA%); P = 0.035] and TGs (β: −0.23 mmol/L; 95% CI: −0.41, −0.05 mmol/L per FA%; P = 0.015), respectively. Conclusions The observed associations with FADS variants indicate that PUFAs are involved in plasma lipid regulation in 9-mo-old infants. Observed FADS SNP differences and interactions with breastfeeding and PPARG2 warrant additional studies to explore the effects of individual FADS SNPs on PUFA status and potential genetic modification of dietary PUFA effects.

scholarly journals ERICA: prevalence of dyslipidemia in Brazilian adolescents

2016 ◽  
Vol 50 (suppl 1) ◽  
Author(s):  
José Rocha Faria Neto ◽  
Vivian Freitas Rezende Bento ◽  
Cristina Pellegrino Baena ◽  
Marcia Olandoski ◽  
Luis Gonzaga de Oliveira Gonçalves ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Significant Proportion ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cardiovascular Risks ◽  
Cross Sectional ◽  
High Prevalence ◽  
Low Hdl

ABSTRACT OBJECTIVE To determine the distribution of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in Brazilian adolescents, as well as the prevalence of altered levels of such parameters. METHODS Data from the Study of Cardiovascular Risks in Adolescents (ERICA) were used. This is a country-wide, school-based cross-sectional study that evaluated 12 to 17-year old adolescents living in cities with over 100,000 inhabitants. The average and distribution of plasma levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were evaluated. Dyslipidemia was determined by levels of total cholesterol ≥ 170 mg/dl, LDL cholesterol ≥ 130 mg/dl, HDL cholesterol < 45 mg/dL, or triglycerides ≥ 130 mg/dl. The data were analyzed by gender, age, and regions in Brazil. RESULTS We evaluated 38,069 adolescents – 59.9% of females, and 54.2% between 15 and 17 years. The average values found were: total cholesterol = 148.1 mg/dl (95%CI 147.1-149.1), HDL cholesterol = 47.3 mg/dl (95%CI 46.7-47.9), LDL cholesterol = 85.3 mg/dl (95%CI 84.5-86.1), and triglycerides = 77.8 mg/dl (95%CI 76.5-79.2). The female adolescents had higher average levels of total cholesterol, LDL cholesterol, and HDL cholesterol, without differences in the levels of triglycerides. We did not observe any significant differences between the average values among 12 to 14 and 15- to 17-year old adolescents. The most prevalent lipid alterations were low HDL cholesterol (46.8% [95%CI 44.8-48.9]), hypercholesterolemia (20.1% [95%CI 19.0-21.3]), and hypertriglyceridemia (7.8% [95%CI 7.1-8.6]). High LDL cholesterol was found in 3.5% (95%CI 3.2-4.0) of the adolescents. Prevalence of low HDL cholesterol was higher in Brazil’s North and Northeast regions. CONCLUSIONS A significant proportion of Brazilian adolescents has alterations in their plasma lipids. The high prevalence of low HDL cholesterol and hypertriglyceridemia, especially in Brazil’s North and Northeast regions, must be analyzed in future studies, to support the creation of strategies for efficient interventions.

Fast lipoprotein chromatography: new method of analysis for plasma lipoproteins

1993 ◽  
Vol 39 (11) ◽  
pp. 2276-2281 ◽  
Author(s):  
W März ◽  
R Siekmeier ◽  
H Scharnagl ◽  
U B Seiffert ◽  
W Gross
Keyword(s):  
Plasma Proteins ◽  
Ldl Cholesterol ◽  
Gel Filtration ◽  
Hdl Cholesterol ◽  
Plasma Lipoproteins ◽  
Precipitation Method ◽  
High Density Lipoproteins ◽  
Vldl Cholesterol ◽  
Novel Method ◽  
Fast Flow

Abstract Fast lipoprotein chromatography (FLPC) is a novel method for quantifying lipoproteins. Plasma proteins are separated by fast-flow gel filtration. Lipoproteins are detected by post-column derivatization with an enzymatic cholesterol reagent. FLPC resolves very-low-, low-, and high-density lipoproteins (VLDL, LDL, and HDL, respectively) and completely separates apolipoprotein Al- and apolipoprotein B-containing lipoproteins. CVs for VLDL-cholesterol, LDL-cholesterol, and HDL-cholesterol are 5.8%, 2.0%, and 1.9%, respectively. We compared FLPC with a combined ultracentrifugation and precipitation method and obtained correlation of r = 0.979, 0.978, and 0.933 for VLDL-cholesterol, LDL-cholesterol, and HDL-cholesterol, respectively. Triglyceride concentrations up to 9.00 g/L did not interfere with the quantification of lipoproteins by FLPC. We conclude that FLPC is a precise and reliable method for the analysis of plasma lipoproteins that complements conventional techniques.

scholarly journals Changes in Lipids and Lipoproteins after Selective LDL Apheresis (7-Year Experience)

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Genovefa Kolovou ◽  
Georgios Hatzigeorgiou ◽  
Constantinos Mihas ◽  
Nikos Gontoras ◽  
Panagiotis Litras ◽  
...  
Keyword(s):  
Cardiovascular Events ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Ldl Apheresis ◽  
Before And After ◽  
Premature Cad ◽  
The Mean ◽  
Lipids And Lipoproteins ◽  
Direct Adsorption

Background. The aim of the study was to investigate the changes in plasma lipids and lipoproteins and the cardiovascular events after selective LDL apheresis. Methods and Results. Two pediatric patients with familial hypercholesterolemia aged 11 and 13 years and 19 dyslipidemic adults aged 41 ± 14 years underwent direct adsorption of lipoproteins (DALI) sessions. The mean follow-up period was 47 ± 23 months. The total cholesterol (TC) values before and after treatment were 8.2 ± 2.2 and 3.1 ± 1.6 mmol/l (318 ± 86 and 122 ± 62 mg/dL), respectively. The interval mean of TC was 6.9 ± 1.9 mmol/l (268 ± 75 mg/dL). The LDL cholesterol concentrations before and after treatment were 6.6 ± 2.1 and 1.7 ± 1.1 mmol/l, (256 ± 82 mg/dL and 65 ± 41 mg/dL), respectively. The percentage of acute LDL cholesterol reduction was 75 ± 11%. Cardiovascular events were observed in seven patients. The average annual event rate was 5.51%. Conclusion. LDL apheresis is a very important therapeutic tool in managing patients at high risk for premature CAD or with aggressive CAD, despite adequate medical treatment.

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