Prediction of Drug-Resistant Epilepsy in Children With Cerebral Palsy

2019 ◽  
Vol 35 (3) ◽  
pp. 187-194
Author(s):  
Itay Tokatly Latzer ◽  
Amit Blumovich ◽  
Liora Sagi ◽  
Shimrit Uliel-Sibony ◽  
Aviva Fattal-Valevski
Keyword(s):  
Cerebral Palsy ◽  
Chart Review ◽  
Operating Characteristic ◽  
Seizure Control ◽  
Retrospective Chart Review ◽  
Clinical Settings ◽  
Drug Resistant ◽  
Children With Cerebral Palsy ◽  
Drug Resistant Epilepsy ◽  
Electroencephalogram Eeg

Epilepsy is estimated to exist in approximately 40% of individuals with cerebral palsy; however, the specific features that make it drug resistant are not well defined. The main aim of this study was to determine the clinical risk factors that could predict drug-resistant epilepsy, in children with cerebral palsy. The study was performed via a retrospective chart review, analyzing clinical parameters of 118 children with cerebral palsy with either drug-resistant epilepsy or controlled epilepsy, between the years 2013 and 2018. We established a predictive model for drug-resistant epilepsy in children with cerebral palsy that is simple to apply in clinical settings and composed of the additive effect of a low Apgar score at 5 minutes, neonatal seizures, focal-onset epilepsy, and focal slowing on electroencephalogram (EEG; area under the receiver operating characteristic of 0.840). Early prediction of drug-resistant epilepsy may benefit to achieve better seizure control in children with cerebral palsy.

Hip surgery and radiology reporting for children with cerebral palsy prior to initiation of a hip surveillance program

2021 ◽  
pp. 1-7
Author(s):  
Kyra Kane ◽  
Marshall Siemens ◽  
Shane Wunder ◽  
Jacqueline Kraushaar ◽  
J. Alexandra Mortimer ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Retrospective Chart Review ◽  
Surveillance Program ◽  
Radiology Reporting ◽  
Reporting Practices ◽  
Hip Displacement ◽  
Primary Surgery ◽  
Radiology Reports ◽  
Children With Cerebral Palsy ◽  
Surveillance Programs

PURPOSE: Hip displacement impacts quality of life for many children with cerebral palsy (CP). While early detection can help avoid dislocation and late-stage surgery, formalized surveillance programs are not ubiquitous. This study aimed to examine: 1) surgical practices around pediatric hip displacement for children with CP in a region without formalized hip surveillance; and 2) utility of MP compared to traditional radiology reporting for quantifying displacement. METHODS: A retrospective chart review examined hip displacement surgeries performed on children with CP between 2007–2016. Surgeries were classified as preventative, reconstructive, or salvage. Pre- and post-operative migration percentage (MP) was calculated for available radiographs using a mobile application and compared using Wilcoxon Signed Ranks test. MPs were also compared with descriptions in the corresponding radiology reports using directed and conventional content analyses. RESULTS: Data from 67 children (115 surgical hips) was included. Primary surgery types included preventative (63.5% hips), reconstructive (36.5%), or salvage (0%). For the 92 hips with both radiology reports and radiographs available, reports contained a range of descriptors that inconsistently reflected the retrospectively-calculated MPs. CONCLUSION: Current radiology reporting practices do not appear to effectively describe hip displacement for children with CP. Therefore, standardized reporting of MP is recommended.

scholarly journals Case Report: Hemispherotomy in the First Days of Life to Treat Drug-Resistant Lesional Epilepsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Konstantin L. Makridis ◽  
Christine Prager ◽  
Anna Tietze ◽  
Deniz A. Atalay ◽  
Sebastian Triller ◽  
...  
Keyword(s):  
Perioperative Management ◽  
Seizure Control ◽  
Neurological Deficits ◽  
Safe Procedure ◽  
Drug Resistant ◽  
Young Infants ◽  
Specialized Center ◽  
Surgical Conditions ◽  
Drug Resistant Epilepsy ◽  
Early Surgical Intervention

Background: Neonatal drug-resistant epilepsy is often caused by perinatal epileptogenic insults such as stroke, ischemia, hemorrhage, and/or genetic defects. Rapid seizure control is particularly important for cognitive development. Since early surgical intervention and thus a short duration of epilepsy should lead to an optimal developmental outcome, we present our experience with hemispherotomy in an infant at the corrected age of 1 week.Methods: We report successful hemispherotomy for drug-resistant epilepsy in an infant with hemimegalencephaly at a corrected age of 1 week.Results: The infant was diagnosed with drug-resistant lesional epilepsy due to hemimegalencephaly affecting the left hemisphere. Given congruent electroclinical findings, we performed a left vertical parasagittal transventricular hemispherotomy after critical interdisciplinary discussion. No complications occurred during the surgery. Intraoperatively; 118 ml of red blood cells (30 ml/kg) and 80 ml of plasma were transfused. The patient has been seizure-free since discharge without further neurological deficits.Conclusion: We demonstrate that early epilepsy surgery is a safe procedure in very young infants if performed in a specialized center experienced with age-specific surgical conditions and perioperative management. The specific surgical difficulties should be weighed against the risk of life-long developmental drawbacks of ongoing detrimental epilepsy.

Efficacy and tolerability of clobazam in adults with drug-refractory epilepsy

2020 ◽  
pp. 10.1212/CPJ.0000000000000992
Author(s):  
Alisha Jamil ◽  
Noah Levinson ◽  
Michael Gelfand ◽  
Chloe E. Hill ◽  
Pouya Khankhanian ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Seizure Frequency ◽  
Retrospective Chart Review ◽  
Adjunctive Treatment ◽  
Drug Resistant ◽  
Before And After ◽  
Initial Cohort ◽  
Epilepsy Classification ◽  
Drug Resistant Epilepsy

ObjectivesTo evaluate the effectiveness and tolerability of clobazam as an adjunctive treatment for adults with drug-resistant epilepsy.MethodsWe performed a single-center, retrospective chart review of patients ≥18 years of age with drug-resistant epilepsy who started clobazam between 2010 and 2018. Included patients had outpatient visits both before and ≥1 month after clobazam initiation. Epilepsy classification, seizure frequency before and after clobazam, duration of clobazam treatment, and adverse effects were analyzed.ResultsA total of 417 patients met inclusion criteria. Mean age was 37.5 years, and 54% of patients were female. Patients were on a mean of 2.4 antiepileptic drugs at time of initiation of clobazam. Epilepsy types were focal (56.8%), Lennox-Gastaut syndrome (LGS) (21.1%), generalized (15.1%), and unclassified (7.0%). At the first follow-up visit ≥1 month after clobazam initiation, 50.3% of patients had >50% reduction in seizure frequency, and 20.5% were seizure-free. Of the initial cohort, 17.1% were followed >1 year and were seizure-free at last follow-up. Response rates did not differ between different epilepsy classifications. Fifty-one percent of patients experienced ≥1 side effect, most commonly lethargy/fatigue (30.7%) or mood changes (10.8%). A total of 178 (42.6%) patients discontinued clobazam, most commonly due to adverse effects (55%).ConclusionsClobazam is effective and safe as a long-term adjunctive therapy for adults with drug-resistant epilepsy; efficacy in off-label use is similar to that in LGS.Classification of evidenceThis study provides Class IV evidence that clobazam is an effective treatment for adults with drug-resistant epilepsy, independent of epilepsy classification.

scholarly journals Deep brain stimulation for seizure control in drug-resistant epilepsy

2018 ◽  
Vol 45 (2) ◽  
pp. E4 ◽  
Author(s):  
Neil Klinger ◽  
Sandeep Mittal
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Seizure Control ◽  
Effective Means ◽  
Drug Resistant ◽  
Thalamic Nuclei ◽  
Stimulation Parameters ◽  
Number Of Patients ◽  
Drug Resistant Epilepsy ◽  
Deep Brain

Antiepileptic drugs prevent morbidity and death in a large number of patients suffering from epilepsy. However, it is estimated that approximately 30% of epileptic patients will not have adequate seizure control with medication alone. Resection of epileptogenic cortex may be indicated in medically refractory cases with a discrete seizure focus in noneloquent cortex. For patients in whom resection is not an option, deep brain stimulation (DBS) may be an effective means of seizure control. Deep brain stimulation targets for treating seizures primarily include the thalamic nuclei, hippocampus, subthalamic nucleus, and cerebellum. A variety of stimulation parameters have been studied, and more recent advances in electrical stimulation to treat epilepsy include responsive neurostimulation. Data suggest that DBS is effective for treating drug-resistant epilepsy.

scholarly journals Hand Use at Home and in Clinical Settings by Children with Cerebral Palsy: A Qualitative Study

2014 ◽  
Vol 22 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Marina Brandão ◽  
Juliana Melo Ocarino ◽  
Kátia Maria Penido Bueno ◽  
Marisa Cotta Mancini
Keyword(s):  
Cerebral Palsy ◽  
Qualitative Study ◽  
Clinical Settings ◽  
Children With Cerebral Palsy ◽  
At Home
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