scholarly journals Comparison of Computational Algorithms for the Classification of Liver Cancer using SELDI Mass Spectrometry: A Case Study

2007 ◽  
Vol 3 ◽  
pp. 117693510700300 ◽  
Author(s):  
Changyu Shen ◽  
Timothy E Breen ◽  
Lacey E Dobrolecki ◽  
C. Max Schmidt ◽  
George W. Sledge ◽  
...  

Introduction As an alternative to DNA microarrays, mass spectrometry based analysis of proteomic patterns has shown great potential in cancer diagnosis. The ultimate application of this technique in clinical settings relies on the advancement of the technology itself and the maturity of the computational tools used to analyze the data. A number of computational algorithms constructed on different principles are available for the classification of disease status based on proteomic patterns. Nevertheless, few studies have addressed the difference in the performance of these approaches. In this report, we describe a comparative case study on the classification accuracy of hepatocellular carcinoma based on the serum proteomic pattern generated from a Surface Enhanced Laser Desorption/Ionization (SELDI) mass spectrometer. Methods Nine supervised classification algorithms are implemented in R software and compared for the classification accuracy. Results We found that the support vector machine with radial function is preferable as a tool for classification of hepatocellular carcinoma using features in SELDI mass spectra. Among the rest of the methods, random forest and prediction analysis of microarrays have better performance. A permutation-based technique reveals that the support vector machine with a radial function seems intrinsically superior in learning from the training data since it has a lower prediction error than others when there is essentially no differential signal. On the other hand, the performance of the random forest and prediction analysis of microarrays rely on their capability of capturing the signals with substantial differentiation between groups. Conclusions Our finding is similar to a previous study, where classification methods based on the Matrix Assisted Laser Desorption/Ionization (MALDI) mass spectrometry are compared for the prediction accuracy of ovarian cancer. The support vector machine, random forest and prediction analysis of microarrays provide better prediction accuracy for hepatocellular carcinoma using SELDI proteomic data than six other approaches.

2019 ◽  
Vol 3 (1) ◽  
pp. 58
Author(s):  
Yefta Christian

<p class="8AbstrakBahasaIndonesia"><span>The growth of online stores nowadays is very rapid. This is supported by faster and better internet infrastructure. The increasing growth of online stores makes the competition more difficult in this business field. It is necessary for online stores to have a website or an application that is able to measure and classify consumers’ spending intentions, so that the consumers will have eyes on things on the sites and applications to make purchases eventually. Classification of online shoppers’ intentions can be done by using several algorithms, such as Naïve Bayes, Multi-Layer Perceptron, Support Vector Machine, Random Forest and J48 Decision Trees. In this case, the comparison of algorithms is done with two tools, WEKA and Sci-Kit Learn by comparing the values of F1-Score, accuracy, Kappa Statistic and mean absolute error. There is a difference between the test results using WEKA and Sci-Kit Learn on the Support Vector Machine algorithm. Based on this research, the Random Forest algorithm is the most appropriate algorithm to be used as an algorithm for classifying online shoppers’ intentions.</span></p>


Author(s):  
Desi Ramayanti

In digital business, the managerial commonly need to process text so that it can be used to support decision-making. The number of text documents contained ideas and opinions is progressing and challenging to understand one by one. Whereas if the data are processed and correctly rendered using machine learning, it can present a general overview of a particular case, organization, or object quickly. Numerous researches have been accomplished in this research area, nevertheless, most of the studies concentrated on English text classification. Every language has various techniques or methods to classify text depending on the characteristics of its grammar. The result of classification among languages may be different even though it used the same algorithm. Given the greatness of text classification, text classification algorithms that can be implemented is the support vector machine (SVM) and Random Forest (RF). Based on the background above, this research is aimed to find out the performance of support vector machine algorithm and random forest in classification of Indonesian text. 1. Result of SVM classifier with cross validation k-10 is derived the best accuracy with value 0.9648, however, it spends computational time as long as 40.118 second. Then, result of RF classifier with values, i.e. 'bootstrap': False, 'min_samples_leaf': 1, 'n_estimators': 10, 'min_samples_split': 3, 'criterion': 'entropy', 'max_features': 3, 'max_depth': None is achieved accuracy is 0.9561 and computational time 109.399 second.


2019 ◽  
Vol 59 (5) ◽  
pp. 1988-2008 ◽  
Author(s):  
Zijian Qin ◽  
Yao Xi ◽  
Shengde Zhang ◽  
Guiping Tu ◽  
Aixia Yan

Geosciences ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 396 ◽  
Author(s):  
Premysl Stych ◽  
Barbora Jerabkova ◽  
Josef Lastovicka ◽  
Martin Riedl ◽  
Daniel Paluba

The objective of this paper is to assess WorldView-2 (WV2) and Landsat OLI (L8) images in the detection of bark beetle outbreaks in the Sumava National Park. WV2 and L8 images were used for the classification of forests infected by bark beetle outbreaks using a Support Vector Machine (SVM) and a Neural Network (NN). After evaluating all the available results, the SVM can be considered the best method used in this study. This classifier achieved the highest overall accuracy and Kappa index for both classified images. In the cases of WV2 and L8, total overall accuracies of 86% and 71% and Kappa indices of 0.84 and 0.66 were achieved with SVM, respectively. The NN algorithm using WV2 also produced very promising results, with over 80% overall accuracy and a Kappa index of 0.79. The methods used in this study may be inspirational for testing other types of satellite data (e.g., Sentinel-2) or other classification algorithms such as the Random Forest Classifier.


2020 ◽  
Vol 10 (24) ◽  
pp. 8932
Author(s):  
Masoud Hajeb ◽  
Sadra Karimzadeh ◽  
Masashi Matsuoka

The evaluation of buildings damage following disasters from natural hazards is a crucial step in determining the extent of the damage and measuring renovation needs. In this study, a combination of the synthetic aperture radar (SAR) and light detection and ranging (LIDAR) data before and after the earthquake were used to assess the damage to buildings caused by the Kumamoto earthquake. For damage assessment, three variables including elevation difference (ELD) and texture difference (TD) in pre- and post-event LIDAR images and coherence difference (CD) in SAR images before and after the event were considered and their results were extracted. Machine learning algorithms including random forest (RDF) and the support vector machine (SVM) were used to classify and predict the rate of damage. The results showed that ELD parameter played a key role in identifying the damaged buildings. The SVM algorithm using the ELD parameter and considering three damage rates, including D0 and D1 (Negligible to slight damages), D2, D3 and D4 (Moderate to Heavy damages) and D5 and D6 (Collapsed buildings) provided an overall accuracy of about 87.1%. In addition, for four damage rates, the overall accuracy was about 78.1%.


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