Body size and the risk of multiple sclerosis in Norway and Italy: The EnvIMS study

2014 ◽  
Vol 21 (4) ◽  
pp. 388-395 ◽  
Author(s):  
Kristin Wesnes ◽  
Trond Riise ◽  
Ilaria Casetta ◽  
Jelena Drulovic ◽  
Enrico Granieri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Risk Factor ◽  
Body Size ◽  
Case Control Study ◽  
Disease Onset ◽  
Large Body ◽  
Population Based ◽  
The Body ◽  
Outdoor Activity ◽  
Control Study

Background: Obesity may be a risk factor for developing multiple sclerosis (MS). Objective: We examined if body size influences the risk of MS in a population-based, case control study. Methods: A total of 953 cases and 1717 controls from Norway and 707 cases and 1333 controls from Italy reported their body size by choosing a silhouette 1 to 9 (largest) every fifth year from age 5 to 30 and at time of study. The body size-related MS risk was defined by odds ratios (ORs) in logistic regression analyses adjusting for age, smoking and outdoor activity. Results: In Norway a large body size (silhouettes 6–9) compared to silhouette 3 increased the risk of MS, especially at age 25 (OR 2.21; 95% CI 1.09–4.46 for men and OR 1.43; 95% CI 0.90–2.27 for women). When comparing silhouette 9 to 1, we found a significant dose-response from age 10 until age 30 peaking at age 25 (sex-adjusted OR 2.83; 95% CI 1.68–4.78). The association was present for at least 15 years prior to disease onset. No significant associations were found in Italy. Conclusions: Obesity from childhood until young adulthood is a likely risk factor for MS with a seemingly stronger effect in Norway than in Italy.

Stressful Life Events as a Risk Factor for Inflammatory Bowel Disease Onset: A Population-Based Case–Control Study

2007 ◽  
Vol 102 (1) ◽  
pp. 122-131 ◽  
Author(s):  
Eric Lerebours ◽  
Corinne Gower-Rousseau ◽  
Veronique Merle ◽  
Franck Brazier ◽  
Stephane Debeugny ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Risk Factor ◽  
Life Events ◽  
Stressful Life Events ◽  
Case Control Study ◽  
Disease Onset ◽  
Population Based ◽  
Case Control ◽  
Inflammatory Bowel ◽  
Control Study

scholarly journals Physical activity is associated with a decreased multiple sclerosis risk: The EnvIMS study

2017 ◽  
Vol 24 (2) ◽  
pp. 150-157 ◽  
Author(s):  
Kristin Wesnes ◽  
Kjell-Morten Myhr ◽  
Trond Riise ◽  
Marianna Cortese ◽  
Maura Pugliatti ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Multiple Sclerosis ◽  
Case Control Study ◽  
Disease Onset ◽  
Pooled Analysis ◽  
Outdoor Activity ◽  
Early Disease ◽  
Multiple Sclerosis Risk ◽  
Control Study

Background: The lifestyle factors smoking and obesity have been associated with the risk of multiple sclerosis (MS). Physical activity (PA) may also be of importance. Objective: To examine the association between PA and MS risk in Italy, Norway, and Sweden and to evaluate the possible influence by established risk factors. Methods: In this case–control study, 1904 cases and 3694 controls were asked to report their average weekly amounts of light and vigorous PA during adolescence on a scale ranging from none to more than 3 hours activity. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) and adjusted for potential confounders. Results: Vigorous PA was inversely associated with MS risk in the pooled analysis ( p-trend < 0.001) with an age- and sex-adjusted OR of 0.74 (95% CI: 0.63–0.87) when comparing the highest and lowest levels. Adjusting for outdoor activity, infectious mononucleosis, body size, and smoking yielded similar results. The association was present in all countries and was not affected by exclusion of patients with early disease onset. Light PA was not associated with the risk of MS. Conclusion: Our findings suggest that vigorous PA can modify the risk of developing MS independent of established risk factors.

scholarly journals Estimating the Marginal Causal Effect of Fish Consumption during Adolescence on Multiple Sclerosis: A Population-Based Incident Case-Control Study

2018 ◽  
Vol 50 (3-4) ◽  
pp. 111-118 ◽  
Author(s):  
Ibrahim Abdollahpour ◽  
Saharnaz Nedjat ◽  
Mohammad Ali Mansournia ◽  
Mohammad Ali Sahraian ◽  
Jay S. Kaufman
Keyword(s):  
Multiple Sclerosis ◽  
Fish Consumption ◽  
Case Control Study ◽  
Causal Effect ◽  
Population Based ◽  
Case Control ◽  
Incident Case ◽  
Control Study

No association between socioeconomic status and risk of multiple sclerosis: A population-based incident case-control study in a developing country

2018 ◽  
Vol 25 ◽  
pp. 292-296 ◽  
Author(s):  
Ibrahim Abdollahpour ◽  
Saharnaz Nedjat ◽  
Yahya Salimi ◽  
Rahmatollah Moradzadeh ◽  
Mohammad Ali Mansournia ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Socioeconomic Status ◽  
Developing Country ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Incident Case ◽  
Control Study

Dietary inflammatory index and risk of multiple sclerosis: Findings from a large population-based incident case–control study

2020 ◽  
Vol 39 (11) ◽  
pp. 3402-3407 ◽  
Author(s):  
Ibrahim Abdollahpour ◽  
Dejan Jakimovski ◽  
Nitin Shivappa ◽  
James R. Hébert ◽  
Farhad Vahid ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Large Population ◽  
Population Based ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Incident Case ◽  
Inflammatory Index ◽  
Control Study

A large case-control study on vaccination as risk factor for multiple sclerosis

Neurology ◽  
2019 ◽  
Vol 93 (9) ◽  
pp. e908-e916 ◽  
Author(s):  
Alexander Hapfelmeier ◽  
Christiane Gasperi ◽  
Ewan Donnachie ◽  
Bernhard Hemmer
Keyword(s):  
Multiple Sclerosis ◽  
Risk Factor ◽  
Crohn Disease ◽  
Claims Data ◽  
Case Control Study ◽  
Cohort Effect ◽  
Case Control ◽  
Logistic Regression Models ◽  
Control Study ◽  
First Diagnosis

ObjectiveTo investigate the hypothesis that vaccination is a risk factor for multiple sclerosis (MS) by use of German ambulatory claims data in a case-control study.MethodsUsing the ambulatory claims data of the Bavarian Association of Statutory Health Insurance Physicians covering 2005–2017, logistic regression models were used to assess the relation between MS (n = 12,262) and vaccinations in the 5 years before first diagnosis. Participants newly diagnosed with Crohn disease (n = 19,296) or psoriasis (n = 112,292) and participants with no history of these autoimmune diseases (n = 79,185) served as controls.ResultsThe odds of MS were lower in participants with a recorded vaccination (odds ratio [OR] 0.870, p < 0.001 vs participants without autoimmune disease; OR 0.919, p < 0.001 vs participants with Crohn disease; OR 0.973, p = 0.177 vs participants with psoriasis). Lower odds were most pronounced for vaccinations against influenza and tick-borne encephalitis. These effects were consistently observed for different time frames, control cohorts, and definitions of the MS cohort. Effect sizes increased toward the time of first diagnosis.ConclusionsResults of the present study do not reveal vaccination to be a risk factor for MS. On the contrary, they consistently suggest that vaccination is associated with a lower likelihood of being diagnosed with MS within the next 5 years. Whether this is a protective effect needs to be addressed by future studies.

Sign in / Sign up

Export Citation Format

Share Document