scholarly journals Terpenoids and Related Compounds from Plants of the Family Compositae (Asteraceae)

2012 ◽  
Vol 7 (4) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Yasunori Yaoita ◽  
Masao Kikuchi ◽  
Koichi Machida
Keyword(s):  
Tussilago Farfara ◽  
The Family ◽  
Erigeron Annuus ◽  
New Compounds ◽  
Related Compounds ◽  
Petasites Japonicus ◽  
Ligularia Stenocephala

This review will summarize the authors’ studies on the structures of terpenoids and related compounds from plants of the family Compositae (Asteraceae). Eighty three new compounds have been obtained and characterized from seven species of the plants, namely, Erigeron annuus (L.) Pers., Erigeron philadelphicus L., Erigeron sumatrensis Retz., Ligularia dentata Hara, Ligularia stenocephala Matsum. et Koidz., Petasites japonicus Maxim. and Tussilago farfara L.

scholarly journals Crystal Chemical Relations in the Shchurovskyite Family: Synthesis and Crystal Structures of K2Cu[Cu3O]2(PO4)4 and K2.35Cu0.825[Cu3O]2(PO4)4

Crystals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 807
Author(s):  
Ilya V. Kornyakov ◽  
Sergey V. Krivovichev
Keyword(s):  
Crystal Structure ◽  
Crystal Structures ◽  
Structural Complexity ◽  
Crystal Chemical ◽  
X Ray Diffraction ◽  
Complexity Measures ◽  
X Ray ◽  
The Family ◽  
Similarities And Differences ◽  
Related Compounds

Single crystals of two novel shchurovskyite-related compounds, K2Cu[Cu3O]2(PO4)4 (1) and K2.35Cu0.825[Cu3O]2(PO4)4 (2), were synthesized by crystallization from gaseous phase and structurally characterized using single-crystal X-ray diffraction analysis. The crystal structures of both compounds are based upon similar Cu-based layers, formed by rods of the [O2Cu6] dimers of oxocentered (OCu4) tetrahedra. The topologies of the layers show both similarities and differences from the shchurovskyite-type layers. The layers are connected in different fashions via additional Cu atoms located in the interlayer, in contrast to shchurovskyite, where the layers are linked by Ca2+ cations. The structures of the shchurovskyite family are characterized using information-based structural complexity measures, which demonstrate that the crystal structure of 1 is the simplest one, whereas that of 2 is the most complex in the family.

Core-modified porphyrins: novel building blocks in chemistry

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aleksey E. Kuznetsov
Keyword(s):  
Periodic Table ◽  
Building Blocks ◽  
Effective Strategy ◽  
Research Groups ◽  
Structures And Properties ◽  
Porphyrin Core ◽  
Living Organisms ◽  
New Compounds ◽  
Related Compounds ◽  
Nitrogen Phosphorus

Abstract Various (metallo)porphyrins and related compounds have been intensively investigated by different research groups due to their extremely important role in living organisms along with their versatile applications in technology. The design of novel porphyrinoids by core-modification, or substitution of pyrrole nitrogens, with the elements of other groups of the Periodic Table has been considered as a highly promising methodology for tuning structures and properties of porphyrinoids and thus opening new possible applications for them. Much effort has been given to the modifications of the porphyrin core with elements of the main groups, namely O, S, Se (chalcogens), and the heavier congener of nitrogen, phosphorus. In general, the porphyrin core modification by replacing nitrogens with heteroatoms is a promising and effective strategy for obtaining new compounds with unusual structures and properties (optical, electrochemical, coordinating, etc.) as well as reactivity. These novel molecules can also be employed as promising building or construction blocks in various applications in the nanotechnology area.

scholarly journals New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 545
Author(s):  
Niccolò Chiaramonte ◽  
Alessio Gabellini ◽  
Andrea Angeli ◽  
Gianluca Bartolucci ◽  
Laura Braconi ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Imidazole Ring ◽  
Aliphatic Chain ◽  
Amino Group ◽  
Carbonic Anhydrase I ◽  
Terminal Amino ◽  
Human Carbonic Anhydrase ◽  
New Compounds ◽  
Related Compounds ◽  
Micromolar Range

A series of histamine (HST)-related compounds were synthesized and tested for their activating properties on five physiologically relevant human Carbonic Anhydrase (hCA) isoforms (I, II, Va, VII and XIII). The imidazole ring of HST was replaced with different 5-membered heterocycles and the length of the aliphatic chain was varied. For the most interesting compounds some modifications on the terminal amino group were also performed. The most sensitive isoform to activation was hCA I (KA values in the low micromolar range), but surprisingly none of the new compounds displayed activity on hCA II. Some derivatives (1, 3a and 22) displayed an interesting selectivity for activating hCA I over hCA II, Va, VII and XIII.

scholarly journals Cyclic Peroxides from a Two-Sponge Association of Plakortis communis-Agelas mauritiana

2013 ◽  
Vol 8 (6) ◽  
pp. 1934578X1300800
Author(s):  
Pinus Jumaryatno ◽  
Lynette K. Lambert ◽  
John N. A. Hooper ◽  
Joanne T. Blanchfield ◽  
Mary J. Garson
Keyword(s):  
2D Nmr ◽  
Side Chain ◽  
Relative Configuration ◽  
Carboxylic Acid Groups ◽  
Rp Hplc ◽  
Chemical Shift Data ◽  
New Compounds ◽  
Cyclic Peroxide ◽  
Related Compounds ◽  
Shift Data

A cyclic peroxide 1 with an unusual phenethenyl side chain, together with the known peroxide 2 with a C4-sidechain have been isolated from a two-sponge association of Plakortis communis – Agelas mauritiana (Carter, 1883) collected near Mooloolaba, South-East Queensland, Australia. Metabolite purification was complicated by the presence of the free carboxylic acid groups in 1 and 2; therefore, diazomethane treatment was undertaken to afford methyl ester 3. Following RP-HPLC purification, the ring-opened analogues 4 and 5 were also obtained. The structures of the new compounds were elucidated on the basis of their 1D and 2D NMR and MS data, and by comparison with literature data. The relative configuration of the isolated peroxides was determined by the interpretation of JH-H values and comparison of the 13C chemical shift data with literature data for related compounds. The bromopyrrole alkaloid longamide (6) was also isolated.

scholarly journals New Unusual Alkaloids from the Ascidian Eudistoma vannamei

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Antônia Torres Ávila Pimenta ◽  
Paula Christine Jimenez ◽  
Letícia Veras Costa-Lotufo ◽  
Raimundo Braz-Filho ◽  
Mary Anne Sousa Lima
Keyword(s):  
Mass Spectrometry ◽  
Meoh Extract ◽  
Peptide Derivative ◽  
New Compounds ◽  
Related Compounds

The MeOH extract of the ascidian Eudistoma vannamei was found to contain three novel compounds, the adenine alkaloid derivatives 9-[ N-(leucyl)-isoleucyl]-adenine (1) and 8-hydroxy-8-isopentyl-7,8-dihydroadenine (2), and the phenylalanine peptide derivative N-[ N-(leucyl)-isoleucyl]phenethylamine (3). Other previously related compounds isolated from this extract include thymidine, 2′-deoxyuridine and phenylalanine. The structures of the new compounds were elucidated through the use of NMR and mass spectrometry.

scholarly journals Boldine and Related Aporphines: From Antioxidant to Antiproliferative Properties

2013 ◽  
Vol 8 (12) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Darina Muthna ◽  
Jana Cmielova ◽  
Pavel Tomsik ◽  
Martina Rezacova
Keyword(s):  
Folk Medicine ◽  
Antioxidant Properties ◽  
The Family ◽  
Drug Synthesis ◽  
Related Compounds

Plant and folk medicine represent nowadays a source of either new therapeutic substances or substrates for drug synthesis. One such promising group for possible further exploitation is the family of aporphine alkaloids containing boldine and related compounds. In this mini-review we focus on boldine and its newly described effects, which predominantly arise from its antioxidant properties. Moreover, we try to compare its antiproliferative properties with other better known members of the aporphine group.

Chemistry of the shellfish toxin domoic acid: characterization of related compounds

1994 ◽  
Vol 72 (2) ◽  
pp. 430-436 ◽  
Author(s):  
John A. Walter ◽  
Michael Falk ◽  
Jeffrey L.C. Wright
Keyword(s):  
Molecular Modelling ◽  
Domoic Acid ◽  
Conformational Flexibility ◽  
Spectroscopic Methods ◽  
Clear Cut ◽  
Nmr Data ◽  
Shellfish Toxin ◽  
New Compounds ◽  
Related Compounds

Five new compounds related to the neurotoxin domoic acid have been characterized by spectroscopic methods. They include a diastereoisomer that occurs naturally with domoic acid in mussels and four hydrogenation products. The stereochemistry of the two epimeric tetrahydro derivatives could not be assigned on the basis of the NMR data alone because of high conformational flexibility. However, a clear-cut assignment was possible by molecular modelling in combination with the NMR data.

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