scholarly journals Lightwave-reinforced stem cells with enhanced wound healing efficacy

2021 ◽  
Vol 12 ◽  
pp. 204173142110670
Author(s):  
Yu-Jin Kim ◽  
Hye Ran Jeon ◽  
Sung-Won Kim ◽  
Yeong Hwan Kim ◽  
Gwang-Bum Im ◽  
...  
Keyword(s):  
Stem Cells ◽  
Light Emitting Diode ◽  
Red Light ◽  
Cell Therapies ◽  
Light Emitting ◽  
Organic Light Emitting Diode ◽  
Cell Adhesion And Migration ◽  
Cellular Capacity ◽  
And Migration

Comprehensive research has led to significant preclinical outcomes in modified human adipose-derived mesenchymal stem cells (hADSCs). Photobiomodulation (PBM), a technique to enhance the cellular capacity of stem cells, has attracted considerable attention owing to its effectiveness and safety. Here, we suggest a red organic light-emitting diode (OLED)-based PBM strategy to augment the therapeutic efficacy of hADSCs. In vitro assessments revealed that hADSCs basked in red OLED light exhibited enhanced angiogenesis, cell adhesion, and migration compared to naïve hADSCs. We demonstrated that the enhancement of cellular capacity was due to an increased level of intracellular reactive oxygen species. Furthermore, accelerated healing and regulated inflammatory response was observed in mice transplanted with red light-basked hADSCs. Overall, our findings suggest that OLED-based PBM may be an easily accessible and attractive approach for tissue regeneration that can be applied to various clinical stem cell therapies.

scholarly journals Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device

2015 ◽  
Vol 08 (04) ◽  
pp. 1550017 ◽  
Author(s):  
Xuewei Jiang ◽  
Zhichao Fan ◽  
Yili Yu ◽  
Chenying Shao ◽  
Yuanzhen Suo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Toluidine Blue ◽  
Pathogenic Bacteria ◽  
Light Emitting Diode ◽  
Red Light ◽  
In Vitro Screening ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Prevotella Melaninogenica

Photodynamic therapy (PDT) has been commonly used in treating many diseases, such as cancer and infectious diseases. We investigated the different effects of PDT on three main pathogenic bacteria of periodontitis — Prevotella melaninogenica (P.m.), Porphyromonas gingivalis (P.g.) and Aggregatibacter actinomycetemcomitans (A.a.). The portable red light-emitting diode (LED) phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations (Toluidine blue O, TBO). The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensitizers (porphyrin) under different light doses. We found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria significantly. Moreover, the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.

Enhanced Red-Light Emission by Local Plasmon Coupling of Au Nanorods in an Organic Light-Emitting Diode

2011 ◽  
Vol 4 (3) ◽  
pp. 032105 ◽  
Author(s):  
Takuya Tanaka ◽  
Yuji Totoki ◽  
Aya Fujiki ◽  
Nobuyuki Zettsu ◽  
Yusuke Miyake ◽  
...  
Keyword(s):  
Light Emission ◽  
Light Emitting Diode ◽  
Red Light ◽  
Plasmon Coupling ◽  
Light Emitting ◽  
Au Nanorods ◽  
Organic Light Emitting Diode ◽  
Organic Light ◽  
Local Plasmon
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