scholarly journals Association of plasma adiponectin with pulmonary hypertension, mortality and heart failure in African Americans: Jackson Heart Study

2020 ◽  
Vol 10 (4) ◽  
pp. 204589402096124
Author(s):  
Suvasini Lakshmanan ◽  
Matthew Jankowich ◽  
Wen-Chih Wu ◽  
Siddique Abbasi ◽  
Alan R Morrison ◽  
...  
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
African Americans ◽  
Management Strategies ◽  
Targeted Prevention ◽  
Jackson Heart Study ◽  
Cross Sectional ◽  
Plasma Adiponectin ◽  
Heart Study ◽  
Observational Cohort

Background Adiponectin is a polypeptide hormone related to obesity, and a known modulator of pulmonary vascular remodeling. Association between plasma adiponectin levels and pulmonary hypertension (PH) has not been studied in African Americans (AAs) who are disproportionately affected by obesity. The relationship between adiponectin and heart failure (HF) and mortality, outcomes associated with PH, is unclear. Methods We performed cross-sectional and longitudinal analysis to examine if there is an association between plasma adiponectin and PH and associated clinical outcomes, in participants of Jackson Heart Study (JHS). JHS is a prospective observational cohort study of heart disease in AAs from Jackson, Mississippi. Results Of the 3161 participants included in the study, mean age (SD) was 56.38 (12.61) years, 1028 were men (32.5%), and mean (SD) BMI was 31.42 (7.05) kg/m2. Median (IQR) adiponectin was 4516.82 (2799.32–7065.85) ng/mL. After adjusting for potential confounders including BMI, higher adiponectin levels were associated with increased odds of PH (adjusted odds ratio per log increment in adiponectin, (1.81; 95% CI, 1.41–2.32). High adiponectin levels were also associated with associated HF admissions (adjusted hazard ratio [HR] per log increment in adiponectin, 1.63, 95% CI, 1.24–2.14) and mortality (adjusted HR per log increment in adiponectin, 1.20; 95% CI 1.02–1.41). Conclusions Elevated plasma adiponectin levels are associated with PH, HF admissions and mortality risk in AAs. High adiponectin levels may help identify an at-risk population that could be evaluated for targeted prevention and management strategies in future studies

scholarly journals Perceived Discrimination and Reported Trust and Satisfaction in African Americans: The Jackson Heart Study

2017 ◽  
Vol 27 (3) ◽  
pp. 209 ◽  
Author(s):  
LáShauntá M. Glover ◽  
Mario Sims ◽  
Karen Winters
Keyword(s):  
African Americans ◽  
Health Care Providers ◽  
Perceived Discrimination ◽  
Discrimination Score ◽  
Care Providers ◽  
Jackson Heart Study ◽  
Cross Sectional ◽  
Heart Study ◽  
The Mean ◽  
Everyday Discrimination

<p class="Pa5"><strong>Objectives: </strong>1) To examine the association of multiple dimensions of discrimination with reported trust and satisfaction with providers; 2) to report within-group differences among African Americans (AAs). </p><p class="Pa5"><strong>Methods: </strong>Descriptive cross sectional study. The study population included AAs aged 35 to 84 years from the Jackson Heart Study (JHS) (N=5,301). Poisson regression (PR) was used to quantify the association between perceived discrimination and reported trust and satisfaction with providers before and after controlling for selected characteristics. </p><p class="Pa5"><strong>Main Measures: </strong>Measures of perceived discrimination included everyday, lifetime, burden from lifetime discrimination, and stress from discrimination. Outcomes included trust and satisfaction with providers. </p><p class="Pa5"><strong>Results: </strong>The mean everyday discrimination score was 2.11 (SD±1.02), and the mean lifetime discrimination score was 2.92 (SD±2.12). High (vs low) levels of everyday discrimination were associated with a 3% reduction in the prevalence of trust in providers (PR .97, 95% CI .96, .99) in all models. In fully-adjusted models, high (vs low) lifetime discrimination was associated with a 4% reduction in the prevalence of trust and satisfaction (PR .96, 95% CI .95, .98). Burden of discrimination was not associated with trust or satisfaction, but stress from discrimination was inversely associated with satisfaction. </p><p class="Pa5"><strong>Conclusions: </strong>The significant association between discrimination and mistrust and dissatisfaction suggests that health care providers should be made aware of AA perceptions of discrimination, which likely affects their levels of trust and satisfaction.</p><p class="Pa5"><em>Ethn Dis. </em>2017;27(3):209-216; doi:10.18865/ed.27.3.209 </p>

scholarly journals Markers of kidney disease and risk of subclinical and clinical heart failure in African Americans: the Jackson Heart Study

2016 ◽  
Vol 31 (12) ◽  
pp. 2057-2064 ◽  
Author(s):  
Nisha Bansal ◽  
Ronit Katz ◽  
Jonathan Himmelfarb ◽  
Maryam Afkarian ◽  
Bryan Kestenbaum ◽  
...  
Keyword(s):  
Heart Failure ◽  
African Americans ◽  
Kidney Disease ◽  
Jackson Heart Study ◽  
Heart Study ◽  
Clinical Heart Failure

scholarly journals The Obesity and Heart Failure Epidemics Among African Americans: Insights From the Jackson Heart Study

2016 ◽  
Vol 22 (8) ◽  
pp. 589-597 ◽  
Author(s):  
Arun Krishnamoorthy ◽  
Melissa A. Greiner ◽  
Alain G. Bertoni ◽  
Zubin J. Eapen ◽  
Emily C. O'Brien ◽  
...  
Keyword(s):  
Heart Failure ◽  
African Americans ◽  
Jackson Heart Study ◽  
Heart Study

Abstract P227: Direct Association of Adiponectin with Individual European Ancestry in African Americans: the Jackson Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Aurelian Bidulescu ◽  
Shweta Choudhry ◽  
Sarah G Buxbaum ◽  
Jiankang Liu ◽  
Dorothy L Coverson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
African Americans ◽  
Waist Circumference ◽  
European Ancestry ◽  
Jackson Heart Study ◽  
Community Based ◽  
Plasma Adiponectin ◽  
Heart Study ◽  
Direct Association ◽  
The Individual

Background: Compared with European Americans, African Americans exhibit lower levels of the cardio-metabolically protective adipokine known as adiponectin even after accounting for adiposity measures. Few studies have examined the association between adiponectin and individual ancestry estimates in African Americans, and most of these studies used only a few hundreds of the ancestry informative markers (AIMs). Therefore, we employed a relatively dense panel of AIMs to estimate the individual proportions of European ancestry (PEA) for the African Americans enrolled in a large community-based cohort in order to test the hypothesis that plasma adiponectin and PEA are directly associated. Methods: Plasma specimens from 1,439 participants with available DNA in the Jackson Heart Study were analyzed by ELISA for adiponectin levels. Using pseudo-ancestral population genotype data from the International HapMap Consortium, PEA was estimated for each individual with a panel of up to 1,447 genome-wide preselected AIMs by a maximum likelihood approach. Insulin resistance, defined as the highest quartile, was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR) and obesity by a body mass index (BMI) greater or equal to 30 kg/m 2 . Interaction assessment and stepwise linear regression models were used to analyze the cross-sectional association between adiponectin and PEA. A p-value less than 0.05 was considered significant for the main and the interactive effects. Results: Among the study participants (62% women; mean age 48 ± 12 years), the median (interquartile range) of PEA was 15.8 (9.3)%. BMI ( p = .0004 ) and insulin resistance ( p = .002 ) were effect modifiers of the assessed association, but not sex ( p = .31 ) or waist circumference ( p = .62 ). Among non-obese individuals (n = 673), adiponectin was directly associated with PEA (β = 3.3 ± 1.5, p = .03 ) after adjustment for age, sex, waist circumference, systolic blood pressure, HOMA-IR, cholesterol fractions, C-reactive protein, physical activity and, in the initial stepwise models, measures of socioeconomic status. Among participants without insulin resistance (n = 1,141), after adjustment for the same variables with the exception of age and HOMA-IR (as indicated by the stepwise procedure), a direct association between adiponectin and PEA was also observed (β = 4.4 ± 1.3, p = .0005 ). Conclusions: In a large community-based African American population, the individual proportion of the global European ancestry was directly associated with plasma adiponectin among participants without impaired lipid or glucose metabolism, namely among those without obesity or insulin-resistance. Our study results point to the genetic origins of the lower levels of adiponectin in African Americans and warrant further exploration of the role ancestry plays in the complex relationship of adiponectin with cardio-metabolic risk factors.

scholarly journals Residential distance to major roadways and cardiac structure in African Americans: cross-sectional results from the Jackson Heart Study

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Anne M. Weaver ◽  
Gregory A. Wellenius ◽  
Wen-Chih Wu ◽  
DeMarc A. Hickson ◽  
Masoor Kamalesh ◽  
...  
Keyword(s):  
African Americans ◽  
Cardiac Structure ◽  
Jackson Heart Study ◽  
Cross Sectional ◽  
Heart Study ◽  
Residential Distance
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