Dietary patterns and risk of bladder cancer: a systematic review and meta-analysis

Background Several studies have investigated the relationship between dietary patterns and the risk of bladder cancer (BC) in different regions including Europe, the United States, and Asia, with no conclusive evidence. A meta-analysis was undertaken to integrate the most recent information on the relationship between a data-driven Western diet (WD), the Mediterranean diet (MD), and dietary-inflammatory-index (DII) and the risk of BC. Method We looked for published research into the relationship between dietary patterns and the incidence of BC in the PubMed/Medline, Cochrane Library, Web of Science, and Scopus databases up until February 2021. Using a multivariate random-effects model, we compared the highest and lowest categories of WD, MD and DII patterns and provided the relative risk (RR) or odds ratios (OR) and 95 percent confidence intervals (CIs) for the relevant relationships. Results The analysis comprised 12 papers that were found to be suitable after scanning the databases. Both case–control (OR 0.73, 95% CI: 0.52, 0.94; I2 = 49.9%, n = 2) and cohort studies (RR 0.93, 95% CI: 0.88, 0.97; I2 = 63%, n = 4) found a substantial inverse association between MD and BC. In addition, although cohort studies (RR 1.53, 95% CI 1.37, 1.70; I2 = 0%, n = 2) showed a direct association between WD and BC, case–control studies (OR 1.33, 95% CI 0.81, 1.88; I2 = 68.5%, n = 2) did not. In cohort studies, we found no significant association between DII and BC (RR 1.02, 95% CI 0.93, 1.12; I2 = 38.5%, n = 2). In case–control studies, however, a strong direct association between DII and BC was discovered (RR 2.04, 95% CI 1.23, 2.85; I2 = 0%, n = 2). Conclusion The current meta-analysis showed that MD and WD have protective and detrimental effects on BC risk, respectively. No significant association between DII and the risk of BC was observed. More research is still needed to confirm the findings. Additional study is warranted to better understand the etiological mechanisms underlying how different dietary patterns affect BC. Trial registration Protocol registration number:CRD42020155353. Database for protocol registration: The international prospective register of systematic reviews database (PROSPERO). Data of registration: August 2020.

Can differences in publisher size account for the relatively low prices of the journals available to master’s universities through commercial publishers’ databases? The importance of price discrimination and substitution effects

Using price quotes and invoices for thousands of full-text databases and single-journal subscriptions, this study confirms that for a typical master’s university, the journals acquired through commercial publishers’ databases cost substantially less than those acquired through the databases of scholarly societies, universities, and other nonprofits. Moreover, the lower prices of commercial publishers’ journals cannot be readily attributed to publisher size (number of journals published) or to any of several other explanatory variables. There is a weak, direct association between publisher size and price among the for-profit journals but a stronger, inverse relationship between publisher size and price among the nonprofit journals. These findings, along with the results of previous research, suggest that resource providers may have incentives to keep prices low due to the collection development strategies adopted by many teaching-oriented colleges and universities. If the library’s goal is to hold a sufficient number of high-quality journals rather than to provide immediate access to every wanted journal, particular journals and databases may be regarded as substitutes even when each product provides unique content. Many U.S. bachelor’s and master’s institutions have goals different from those of the major research universities, and commercial publishers (along with some of the larger nonprofits) seem to recognize this when setting and negotiating prices.

HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma

Background. Ameloblastoma (AMB) is a benign odontogenic tumour, with an aggressive local behaviour and a high rate of recurrence. Previous studies have demonstrated that hypoxia-induced factor alpha 1 (HIF-1α) and activated caspase-3 contribute to tumour invasiveness and cytogenesis in ameloblastoma. Hypoxia increases HIF-1α levels, which triggers a number of signalling pathways. This paper aimed to present data in the study of hypoxia-activated signalling pathways that modulate proapoptotic and antiapoptotic events in AMB. Methods. Twenty cases of AMB and ten cases of dental follicle (DF) were used to analyse the immunoexpression of HIF-1α, p53, BNIP3, Bcl-2, IAP-2, GLUT1, and Bax. To contribute to the study, an analysis of expression and genetic interaction was performed using the cell line AME-1. Results. AMB and DF expressed the studied proteins. These proteins showed significantly greater immunoexpression in AMB compared with the DF ( p < 0.05 ). HIF-1α showed an important association with GLUT1, and a positive correlation was observed among p53, Bcl-2, and IAP-2. Transcriptomic analysis showed the significant expression of the studied proteins, and the network generated showed a direct association of HIF-1αF with GLUT1 (SLC2A1), TP53, and LDHA. Interestingly, GLUT1 also exhibited direct interaction with TP53 and LDHA. Conclusion. In AMB tumorigenesis, hypoxia is possibly related to antiapoptotic events, which suggests an important role for HIF-1α, GLUT1, Bcl-2, IAP-2, and possibly p53.

Environmental Conditions Associated With Youth Delinquency Events: A Temporal, Meteorological, and Contextual Perspective

Research on youth delinquency has been essential for gaining a deeper understanding of the etiology of delinquent behavior. Studies considering the environmental perspective have increased during the last decade, but relatively little attention has been paid to temporal patterns and weather conditions. The present study explores the seasonality of youth delinquency as well as the association between violent and non-violent youth offenses and temperature, rainfall, level of darkness, type of day, type of place, and companionship, using data gathered by the police along with data obtained from official weather agencies. To this end, we conducted ANOVA and contingency table analyses. Seasonality was found for non-violent crimes. Companionship, semi-public, and public places were all associated with a higher likelihood of non-violent crime, while darkness and public holidays raise the odds of violent crime to happen. No direct association was found between temperature and type of crime.

Perioperative Use of Vedolizumab in Crohn’s Disease Patients and Surgical Outcomes

Despite advancement in managing Crohn’s disease (CD), a considerable proportion of cases still need surgical intervention, which is an essential means in therapy algorithms. Other drugs of the biologics are recently available, while most CD cases having operations have previously received a drug of this class. This class of agents has a direct association with higher postoperative complication rates, which raises a lot of controversies. In this review summarize the essential data concerning the vedolizumab effect on CD’s postoperative results. The previous data did not demonstrate a cause-effect absolute connection between the increased postoperative morbidities and vedolizumab. Many routing factors unquestionably affect CD’s postoperative outcomes and complications, like malnutrition, unsuitable abdominal settings, and steroids’ previous use. Using vedolizumab perioperatively seems safe. Nevertheless, a definitive relationship from the available data is controversial. Personalized, multidisciplinary evaluations and decisions should be made for each case independently, adjusting the surgical plan regarding the involved risk factors.

The Hoard of Celtic Coins from Deutsch Jahrndorf (Austria, 1855)

The Deutsch Jahrndorf (Burgenland, Austria) hoard was discovered in 1855. It contained Bratislava Celtic coinage – gold denominations and silver tetradrachms of the Biatec group. Altogether, 163 coins have been studied either by autopsy or from their earlier publications; originally however, they were surely more numerous. Although the treasure was discovered south of the Danube, 15 km away from the Bratislava oppidum acropolis, there is no doubt about its direct association with this site. Its contents provide a unique insight into the production of gold denominations, both anepigraphic and with the legends BIATEC or BIAT. Silver tetradrachms of the Biatec group include the majority of known die combinations. The Deutsch Jahrndorf hoard represents a unique source for better understanding the Bratislava coin production. Based on our present state of knowledge of the late La Tène chronology, the hoard was probably concealed in the third quarter of the 1st century BC; a more precise date cannot be established. New discoveries of Roman style constructions on the Bratislava oppidum acropolis help us better understand the phenomenon of relations between the Roman Republic and local Celtic elites; the detailed study of the hoard in question contributes to this topic from the numismatic point of view.

Influence of Internalised Homonegativity on Sexual Risk Behaviour of Men Who Have Sex with Men in Spain

In a sample of men who have sex with men (MSM) (N = 3436) in Spain who bear intrinsic HIV risk, we investigated how internalised homonegativity (IH) is associated with the number of non-steady male partners with condomless intercourse (as a proxy of sexual risk behaviour). Using structural equation modelling (SEM), we examined the relationship between IH and sexual risk behaviour, and mediating effects of HIV/PrEP knowledge and substance use during sex on this relationship. We found no direct association between IH and sexual risk behaviour, nor did IH influence substance use during sex. In line with our hypothesis, association between IH and sexual risk behaviour was significant when mediated by HIV/PrEP knowledge. We found that as IH increased, sexual risk behaviour decreased, because higher IH was associated with lower HIV/PrEP knowledge while higher HIV/PrEP knowledge was associated with increased non-condom use with non-steady partners. Substance use during sex was significantly associated with sexual risk behaviour. Our results emphasize the continuing importance of prevention strategies focused on behavioural changes and community level interventions, especially targeting substance use.

Text Neck Syndrome: The Pain of Modern Era

Introduction- The text neck syndrome is a repetitive stress injury induced by prolonged neck flexion at different angles and pain sustained from excessive watching or texting on handheld devices for long periods. It should be referred to as "Modern Era Pain" due to its direct association with the modern era's Gadgets. Aim - This study aimed to determine the prevalence of text neck syndrome and neck pain among college students and to find the effect of neck pain on their active daily lives. Methodology - A personalized questionnaire was designed in the Google Forms and distributed among the around college students by using Snowball sampling techniques. The questionnaire contained four parts: consent letter, sociodemographic details, NDI questionnaire, and fourth part of questionnaire contained vas scale and personalized question about how neck pain impact their active daily life. Result – Out of 283 responses, 36.5 percent of respondents reported mild text neck syndrome, 23.4 percent reported moderate, 2.1 percent reported severe and complete text neck syndrome, and 35.7 percent did not suffer text neck syndrome. And 73.4 % people reported mild to severe pain in neck and upper back region. Conclusion- Prevalence of text neck syndrome is found greater in study as compared to the findings of other previous studies. Key words: Neck pain, Pain of modern era, NDI, Upper back pain, Musculoskeletal disorder.

EXPRESS: Lexically-independent representation of the monotransitive structure

Many previous studies have shown that syntactic priming tends to be stronger when the verb is repeated between the prime and target sentences. This phenomenon is known as the lexical boost and has been interpreted as evidence for a direct association between individual verbs and structural information. However, Van Gompel, Arai, and Pearson (2012) found no lexical boost with the monotransitive structure and argued that this structure is not associated with individual lexical items. Their results instead suggested that monotransitive structure information is represented at the category-general level. The current study examined whether this finding generalizes to verbs that can take either a monotransitive structure or a ditransitive structure. Our results demonstrated a lexical boost with double object ditransitive primes but not with monotransitive primes. This suggests that the monotransitive structure is indeed represented at the category-general level across different classes of verbs, whereas other structures are represented at the lexically-specific level.

Cattle Maternal Diversity Inferred From 1,883 Taurine And Indicine Mitogenomes

Maternal diversity based on a sub-region of mitochondrial genome or variants were commonly used to understand past demographic events in livestock. Additionally, there is growing evidence of direct association of mitochondrial genetic variants with a range of phenotypes. Therefore, this study used bovine complete mitogenomes from a large sequence database to explore the full spectrum of maternal diversity. Mitogenome diversity was evaluated among 1883 animals representing 156 globally important cattle breeds. Overall, the mitogenomes were diverse: presenting 11 major haplogroups, expanding to 1309 unique haplotypes, with nucleotide diversity 0.011 and haplotype diversity 0.99. A small proportion of African taurine (3.5%) and indicine (1.3%) haplogroups were found among the European taurine breeds and composites. The haplogrouping was largely consistent with the population structure derived from alternate clustering methods (e.g. PCA and hierarchical clustering). Further, we present evidence confirming a new indicine subgroup (I1a, 64 animals) mainly consisting of breeds originating from China and characterised by two private mutations within the I1 haplogroup. The total genetic variation was attributed mainly to within-breed variance (96.9%). The accuracy of the imputation of missing genotypes was high (99.8%) except for the relatively rare heteroplasmic genotypes, suggesting the potential for trait association studies within a breed.