Does body mass index impact the efficacy and complication rate of mini-percutaneous nephrolithotomy?

2020 ◽  
pp. 205141582093688
Author(s):  
Hannah Burns ◽  
Nafees Ahmad ◽  
Jane Hendry ◽  
Sarath Nalagatla
Keyword(s):  
Body Mass Index ◽  
Length Of Stay ◽  
Body Mass ◽  
Percutaneous Nephrolithotomy ◽  
Complication Rate ◽  
Clearance Rate ◽  
Obese Patients ◽  
Clearance Rates ◽  
Stone Clearance ◽  
Severely Obese

Aim: This was a retrospective cohort study exploring the efficacy of mini-percutaneous nephrolithotomy in obese patients and whether stone clearance, complication rate and length of stay is impacted by an increasing body mass index. Method: Data was collected retrospectively for all mini-percutaneous nephrolithotomies performed at a single centre over a 21-month period commencing March 2017. The primary outcomes included length of stay, stone clearance rates and complications. Results: Fifty-eight percutaneous nephrolithotomies were undertaken during the study period and of these cases 81% of patients had a body mass index of 25 or greater. The stone clearance rate was 83%. However, severely obese patients were noted to have a lower stone clearance rate. No complications occurred in the normal body mass index cohort. However, there was no difference in the complication rate for the remaining groups. Post-operative stay was approximately 3 days. Conclusion: This study demonstrates that supine mini-percutaneous nephrolithotomies are a safe option in obese patients with no increased risk of serious complication. Whilst stone clearance rates were lower in the severely obese category, clearance was complete in the majority of cases. Level of evidence: 3

scholarly journals The Single Nucleotide PolymorphismPPARG2Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ana Paula dos Santos Rodrigues ◽  
Lorena Pereira Souza Rosa ◽  
Hugo Delleon da Silva ◽  
Elisângela de Paula Silveira-Lacerda ◽  
Erika Aparecida Silveira
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Body Composition ◽  
Body Mass ◽  
Fat Mass ◽  
Obese Patients ◽  
Pro12ala Polymorphism ◽  
Logistic Regression Models ◽  
Severely Obese

Background. ThePPARG2Pro12Ala (rs1801282) andIL6-174G >C (rs1800795) have important function in body weight regulation and a potential role in obesity risk. We aimed to investigate the association betweenPPARG2Pro12Ala andIL6-174G >C variants and the genotypes interaction with body composition, metabolic markers, food consumption, and physical activity in severely obese patients.Methods. 150 severely obese patients (body mass index (BMI) ≥ 35 kg/m2) from Central Brazil were recruited. Body composition, metabolic parameters, physical activity, and dietary intake were measured. The genotype was determined by the qPCR TaqMan Assays System. Multiple linear regression and multiple logistic regression models were fitted adjusting for confounders.Results. Ala carriers of the Pro12Ala polymorphism had higher adiposity measures (BMI:p=0.031, and fat mass:p=0.049) and systolic blood pressure (p=0.026) compared to Pro homozygotes. We found no important associations between the -174G >C polymorphism and obesity phenotypes. When genotypes were combined, individuals with genotypes ProAla + AlaAla and GC + CC presented higher BMI (p=0.029) and higher polyunsaturated fatty acids (PUFAs) consumption (p=0.045) compared to the ones with genotypes ProPro and GG, and individuals carriers of thePPARG2Ala allele only (genotype ProAla + AlaAla and GG) had higher fat mass and systolic and diastolic blood pressure compared to the ones with genotypes ProPro and GG.Conclusions. Severely obese individuals carrying the Ala allele of thePPARG2Pro12Ala polymorphism had higher measures of adiposity and blood pressure, while no important associations were found for theIL6-174G >C polymorphism.

Percutaneous nephrolithotomy in super obese patients (body mass index ≥ 50 kg/m2): overcoming the challenges

2015 ◽  
Vol 117 (2) ◽  
pp. 300-306 ◽  
Author(s):  
Mohamed Keheila ◽  
David Leavitt ◽  
Riccardo Galli ◽  
Piruz Motamedinia ◽  
Nithin Theckumparampil ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Percutaneous Nephrolithotomy ◽  
Obese Patients ◽  
Super Obese

scholarly journals Body Mass Index and Intensive Care Unit Outcomes in African American Patients

2017 ◽  
Vol 27 (2) ◽  
pp. 161 ◽  
Author(s):  
O’Dene Lewis ◽  
Julius Ngwa ◽  
Angesom Kibreab ◽  
Marc Phillpotts ◽  
Alicia Thomas ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Length Of Stay ◽  
Body Mass ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Obese Patients ◽  
Icu Mortality

<p class="Pa5"><strong>Purpose: </strong>We sought to determine whether body mass index (BMI) is associated with worse intensive care unit (ICU) outcomes among Black patients.</p><p class="Pa5"><strong>Methods: </strong>Patients admitted to the medical ICU during 2012 were categorized into six BMI groups based on the World Health Organization criteria. ICU mortality, ICU and hospital length of stay (LOS), need for and duration of mechanical ventilation and organ failure rate were assessed.</p><p class="Pa5"><strong>Results: </strong>A total of 605 patients with mean age 58.9 ± 16.0 years were studied. Compared with those with normal BMI, obese patients had significant higher rates of hypertension, diabetes mellitus and obstructive sleep apnea diagnoses (P&lt;.001 for all). A total of 100 (16.5%) patients died during their ICU stay. Obesity was not associated with increased odds of ICU mortality (OR=.58; 95% CI, .16-2.20). Moreover, improved survival was observed for class II obese patients (OR, .031; 95% CI, .001–.863). There were no differences in the need for and duration of mechanical ventilation between the BMI groups. How­ever, ICU and hospital LOS were significant­ly longer in patients with obesity.</p><p><strong>Conclusion: </strong>Obesity was not associated with increased ICU mortality; however, obesity was associated with increased comorbid illness and with significant longer ICU and hospital length of stay. <em></em></p><p><em>Ethn Dis.</em>2017;27(2):161-168; doi:10.18865/ed.27.2.161</p>

The Effect of Body Mass Index on Stone-Free Rate and Operative Complication Rate of Percutaneous Nephrolithotomy

2011 ◽  
Vol 5 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Mai A. Banakhar ◽  
Ahmed J. Al-Sayyad ◽  
Abdul malik M. Altayib ◽  
Hisham A. Mosli
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Percutaneous Nephrolithotomy ◽  
Complication Rate ◽  
Operative Complication ◽  
Stone Free Rate ◽  
Free Rate

Body mass index and mortality in patients with gastric cancer: A large cohort study.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 16-16
Author(s):  
Jung Hwan Lee ◽  
Boram Park ◽  
Jungnam Joo ◽  
Young-Il Kim ◽  
Chan Gyoo Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Body Mass Index ◽  
Overall Survival ◽  
Body Mass ◽  
Normal Weight ◽  
Large Cohort ◽  
Obese Patients ◽  
All Cause Mortality ◽  
Severely Obese ◽  
Disease Specific

16 Background: Although excess body weight has been known to be an important risk factor for mortality from many cancers including colorectal, endometrial and breast cancers, the prognosis of gastric cancer (GC) in obese patients seems controversial. Methods: We aimed to evaluate the association between body mass index (BMI) and mortality in GC in a large cohort. A single institute cohort of 7,765 GC patients undergoing curative gastrectomy between October 2000 and June 2016 were categorized into 6 groups; underweight (< 18.5 kg/m2), normal (18.5 to < 23 kg/m2), overweight (23 to < 25 kg/m2), obese I (25 to < 28 kg/m2), obese II (28 to < 30 kg/m2), and severely obese (≥30 kg/m2). The hazard ratios (HRs) for overall survival and disease-specific survival were calculated using Cox proportional hazard model. Results: We identified 1,279 all-cause and 763 disease-specific deaths among 7,765 patients, and the median follow-up period was 83.05 months (range, 1.02-186.97 months). In multivariable analyses adjusted by age, sex, tumor stage, comorbidity and operation methods, preoperative BMI was associated with all-cause mortality in a nonlinear pattern. As compared with patients who were normal weight, underweight BMI showed increasing mortality risk (hazard ratio (HR), 1.42, 95% confidence interval (CI), 1.15-1.77). In contrast, patients who were overweight (HR, 0.84; 95% CI, 0.73-0.97), obese I (HR, 0.77; 95% CI, 0.66-0.90) and obese II (HR, 0.77; 95% CI, 0.59-1.01) had lower risk of mortality. disease-specific mortality also had a similar pattern to overall survival showing the lowest mortality in obese II group (HR, 0.59; 95% CI, 0.40-0.88). There was no significant difference in severely obese patients in both all-cause and disease-specific mortalities. In spline analyses illustrated by a bell-shaped curve, risk for all-cause mortality was the lowest in patients with 26.67 kg/m2. Conclusions: Preoperative overweight and obese patients (23 to < 30 kg/m2) had lower all-cause and disease-specific mortalities compared to those with normal weight in GC patients who underwent curative surgical resection.

scholarly journals Higher body mass index is associated with larger postoperative improvement in patient-reported outcomes following total knee arthroplasty

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
K Giesinger ◽  
JM Giesinger ◽  
DF Hamilton ◽  
J Rechsteiner ◽  
A Ladurner
Keyword(s):  
Body Mass Index ◽  
Total Knee Arthroplasty ◽  
Pain Relief ◽  
Body Mass ◽  
Knee Arthroplasty ◽  
Normal Weight ◽  
World Health ◽  
Obese Patients ◽  
Total Knee ◽  
The Impact

Abstract Background Total knee arthroplasty is known to successfully alleviate pain and improve function in endstage knee osteoarthritis. However, there is some controversy with regard to the influence of obesity on clinical benefits after TKA. The aim of this study was to investigate the impact of body mass index (BMI) on improvement in pain, function and general health status following total knee arthroplasty (TKA). Methods A single-centre retrospective analysis of primary TKAs performed between 2006 and 2016 was performed. Data were collected preoperatively and 12-month postoperatively using WOMAC score and EQ-5D. Longitudinal score change was compared across the BMI categories identified by the World Health Organization. Results Data from 1565 patients [mean age 69.1, 62.2% women] were accessed. Weight distribution was: 21.2% BMI < 25.0 kg/m2, 36.9% BMI 25.0–29.9 kg/m2, 27.0% BMI 30.0–34.9 kg/m2, 10.2% BMI 35.0–39.9 kg/m2, and 4.6% BMI ≥ 40.0 kg/m2. All outcome measures improved between preoperative and 12-month follow-up (p < 0.001). In pairwise comparisons against normal weight patients, patients with class I-II obesity showed larger improvement on the WOMAC function and total score. For WOMAC pain improvements were larger for all three obesity classes. Conclusions Post-operative improvement in joint-specific outcomes was larger in obese patients compared to normal weight patients. These findings suggest that obese patients may have the greatest benefits from TKA with regard to function and pain relief one year post-op. Well balanced treatment decisions should fully account for both: Higher benefits in terms of pain relief and function as well as increased potential risks and complications. Trial registration This trial has been registered with the ethics committee of Eastern Switzerland (EKOS; Project-ID: EKOS 2020–00,879)

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