scholarly journals Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning

2021 ◽  
Vol 5 ◽  
pp. 239821282110027
Author(s):  
Markus Bauer ◽  
Matthew G. Buckley ◽  
Tobias Bast
Keyword(s):  
Individual Differences ◽  
Spatial Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Place Learning ◽  
Theta Band ◽  
Delayed Matching ◽  
Place Task ◽  
The Right ◽  
Encoding And Retrieval

Spatial memory has been closely related to the medial temporal lobe and theta oscillations are thought to play a key role. However, it remains difficult to investigate medial temporal lobe activation related to spatial memory with non-invasive electrophysiological methods in humans. Here, we combined the virtual delayed-matching-to-place task, reverse-translated from the watermaze delayed-matching-to-place task in rats, with high-density electroencephalography recordings. Healthy young volunteers performed this computerised task in a virtual circular arena, which contained a hidden target whose location moved to a new place every four trials, allowing the assessment of rapid memory formation. Using behavioural measures as predictor variables for source reconstructed frequency-specific electroencephalography power, we found that inter-individual differences in ‘search preference’ during ‘probe trials’, a measure of one-trial place learning known from rodent studies to be particularly hippocampus-dependent, correlated predominantly with distinct theta-band oscillations (approximately 7 Hz), particularly in the right temporal lobe, the right striatum and inferior occipital cortex or cerebellum. This pattern was found during both encoding and retrieval/expression, but not in control analyses and could not be explained by motor confounds. Alpha-activity in sensorimotor and parietal cortex contralateral to the hand used for navigation also correlated (inversely) with search preference. This latter finding likely reflects movement-related factors associated with task performance, as well as a frequency difference in (ongoing) alpha-rhythm for high-performers versus low-performers that may contribute to these results indirectly. Relating inter-individual differences in ongoing brain activity to behaviour in a continuous rapid place-learning task that is suitable for a variety of populations, we could demonstrate that memory-related theta-band activity in temporal lobe can be measured with electroencephalography recordings. This approach holds great potential for further studies investigating the interactions within this network during encoding and retrieval, as well as neuromodulatory impacts and age-related changes.

scholarly journals Individual differences in theta-band oscillations in a spatial memory network revealed by EEG predict rapid place learning

2020 ◽  
Author(s):  
Markus Bauer ◽  
Matthew G. Buckley ◽  
Tobias Bast
Keyword(s):  
Individual Differences ◽  
Spatial Memory ◽  
Temporal Lobe ◽  
Occipital Cortex ◽  
Place Learning ◽  
Theta Oscillations ◽  
Theta Band ◽  
Eeg Recordings ◽  
The Right ◽  
Encoding And Retrieval

AbstractSpatial memory has been closely related to the medial temporal lobe (MTL), and theta-oscillations are thought to play a key role. However, it remains difficult to investigate medio-temporal lobe (MTL) activation related to spatial memory with non-invasive electrophysiological methods in humans.Here, we combined the virtual delayed-matching-to-place (DMP) task, reverse-translated from the watermaze DMP task in rats, with high-density electroencephalography (EEG) recordings. Healthy young volunteers performed this computerised task in a virtual circular arena, which contained a hidden target whose location moved to a new place every four trials, allowing the assessment of rapid memory formation.Using behavioural measures as predictor variables for source reconstructed frequency specific EEG power, we found that inter-individual differences in ‘search preference’ during ‘probe trials’, a measure of 1-trial place learning known from rodent studies to be particularly hippocampus dependent, correlated predominantly with distinct theta-band oscillations (approx. 7 Hz), particularly in the right temporal lobe, the right striatum and inferior occipital cortex or cerebellum. Notably, this pattern was found with very high consistency during both encoding and retrieval/expression, but not in control analyses and could not be explained by motor confounds. Alpha-activity in sensorimotor and parietal cortex contralateral to the hand used for navigation also correlated with search preference, which likely reflected movement-related factors associated with task performance.Relating inter-individual differences in ongoing brain activity to behaviour in a continuous rapid place learning task that is suitable for a variety of populations, we could demonstrate that memory related theta-band activity in temporal lobe can be measured with EEG recordings, revealing a presumed network of MTL, striatum and cerebellum and/or inferior occipital cortex that may interact through theta oscillations. This approach holds great potential for further studies investigating the interactions within this network during encoding and retrieval, as well as neuromodulatory impacts and age-related changes.

scholarly journals Individual differences in neurocognitive aging of the medial temporal lobe

AGE ◽  
2006 ◽  
Vol 28 (3) ◽  
pp. 221-233 ◽  
Author(s):  
Michela Gallagher ◽  
Carlo Colantuoni ◽  
Howard Eichenbaum ◽  
Rebecca P. Haberman ◽  
Peter R. Rapp ◽  
...  
Keyword(s):  
Individual Differences ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Neurocognitive Aging

scholarly journals Characterization of the hemodynamic response of the hippocampal and parahippocampal regions using FMRI

2021 ◽  
Author(s):  
Priyanka Mehta
Keyword(s):  
Spatial Memory ◽  
Medial Temporal Lobe ◽  
Dominant Role ◽  
Memory Task ◽  
Hemodynamic Response ◽  
Hemodynamic Responses ◽  
Memory Processing ◽  
Time To Peak ◽  
Hemodynamic Characteristics ◽  
The Right

Previous neuroimaging studies have suggested a dominant role of the right medial temporal lobe (MTL) structures- the hippocampal and parahippocampal regions in spatial memory processing. However, the underlying physiological hemodynamic response functions (HRF) of the MTL substructures remain undefined. Given the neuroanatomical differences between these substructures, it is posited that their hemodynamic characteristics are distinct. In this study, the hemodynamic responses of the MTL substructures are investigated using an optimization algorithm that penalizes the curvature (i.e. second derivative) of HRF. The time-to-peak characteristic of the hemodynamic responses revealed that the right CA3 and DG subfields of the hippocampus are significantly more active than the right CA1 subfield during a specific spatial memory task. Further, the hemodynamic responses of the entorhinal, perirhinal and parahippocampal cortices are presented. Together, these findings may help advance our understanding of neurodegenerative diseases like epilepsy and Alzheimer’s disease that are strongly associated to hippocampal dysfunction.

scholarly journals Medial temporal lobe BOLD activity at rest predicts individual differences in memory ability in healthy young adults

2008 ◽  
Vol 105 (47) ◽  
pp. 18555-18560 ◽  
Author(s):  
G. S. Wig ◽  
S. T. Grafton ◽  
K. E. Demos ◽  
G. L. Wolford ◽  
S. E. Petersen ◽  
...  
Keyword(s):  
Young Adults ◽  
Individual Differences ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Ability

scholarly journals An Exploratory Study of the Relationship between Face Recognition Memory and the Volume of Medial Temporal Lobe Structures in Healthy Young Males

1998 ◽  
Vol 11 (1) ◽  
pp. 3-20 ◽  
Author(s):  
Clare E. Mackay ◽  
Neil Roberts ◽  
Andrew R. Mayes ◽  
John J. Downes ◽  
Jonathan K. Foster ◽  
...  
Keyword(s):  
Face Recognition ◽  
Recognition Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Multiple Comparisons ◽  
Cerebral Hemispheres ◽  
Parahippocampal Gyrus ◽  
Bonferroni Correction ◽  
Temporal Pole ◽  
The Right

A rigorous new methodology was applied to the study of structure function relationships in the living human brain. Face recognition memory (FRM) and other cognitive measures were made in 29 healthy young male subjects (mean age = 21.7 years) and related to volumetric measurements of their cerebral hemispheres and of structures in their medial temporal lobes, obtained using the Cavalieri method in combination with high resolution Magnetic Resonance Imaging (MRI. Greatest proportional variability in volumes was found for the lateral ventricles (57%) for the cerebral hemispheres (8%) in the mean volumes of the hippocampus, parahippocampal gyrus, amygdala, caudate nucleus, temporal pole and temporal lobe on the right and left sides of the brain. The volumes of the right and left parahippocampal gyrus, temporal pole, temporal lobe, and left hippocampus were, prior to application of the Bonferroni correction to take account of 12 multiple comparisons, significantly correlated with the volume of the corresponding hemisphere (p< 0.05). The volumes of all structures were highly correlated (p< 0.0002 for all comparisons) between the two cerebral hemispheres. There were no positive relationships between structure volumes and FRM score. However, the volume of the right amygdala was, prior to application of the Bonferroni correction to take account of 38~multiple comparisons, found to be significantly smaller in the five most consistent high scorers compared to the five most consistent low scorers (t= 2.77,p= 0.025). The implications for possible relationships between healthy medial temporal lobe structures and memory are discussed.

Visuo-spatial memory deficits following medial temporal lobe damage: A comparison of three patient groups

2016 ◽  
Vol 81 ◽  
pp. 168-179 ◽  
Author(s):  
Nazli Esfahani-Bayerl ◽  
Carsten Finke ◽  
Mischa Braun ◽  
Emrah Düzel ◽  
Hauke R. Heekeren ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Deficits ◽  
Patient Groups

scholarly journals Medial temporal lobe activation during encoding and retrieval of novel face-name pairs

Hippocampus ◽  
2004 ◽  
Vol 14 (7) ◽  
pp. 919-930 ◽  
Author(s):  
C. Brock Kirwan ◽  
Craig E.L. Stark
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Encoding And Retrieval

scholarly journals Age-related Alterations in Simple Declarative Memory and the Effect of Negative Stimulus Valence

2009 ◽  
Vol 21 (10) ◽  
pp. 1920-1933 ◽  
Author(s):  
Vishnu P. Murty ◽  
Fabio Sambataro ◽  
Saumitra Das ◽  
Hao-Yang Tan ◽  
Joseph H. Callicott ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Neural Activity ◽  
Medial Temporal Lobe ◽  
Declarative Memory ◽  
Recognition Performance ◽  
Negative Stimulus ◽  
Main Effect ◽  
Stimulus Valence ◽  
Effect Of Age ◽  
Encoding And Retrieval

Healthy aging has been shown to modulate the neural circuitry underlying simple declarative memory; however, the functional impact of negative stimulus valence on these changes has not been fully investigated. Using BOLD fMRI, we explored the effects of aging on behavioral performance, neural activity, and functional coupling during the encoding and retrieval of novel aversive and neutral scenes. Behaviorally, there was a main effect of valence with better recognition performance for aversive greater than neutral stimuli in both age groups. There was also a main effect of age with better recognition performance in younger participants compared to older participants. At the imaging level, there was a main effect of valence with increased activity in the medial-temporal lobe (amygdala and hippocampus) during both encoding and retrieval of aversive relative to neutral stimuli. There was also a main effect of age with older participants showing decreased engagement of medial-temporal lobe structures and increased engagement of prefrontal structures during both encoding and retrieval sessions. Interestingly, older participants presented with relatively decreased amygdalar–hippocampal coupling and increased amygdalar–prefrontal coupling when compared to younger participants. Furthermore, older participants showed increased activation in prefrontal cortices and decreased activation in the amygdala when contrasting the retrieval of aversive and neutral scenes. These results suggest that although normal aging is associated with a decline in declarative memory with alterations in the neural activity and connectivity of brain regions underlying simple declarative memory, memory for aversive stimuli is relatively better preserved than for neutral stimuli, possibly through greater compensatory prefrontal cortical activity.

Modulation of encoding and retrieval by recollection and familiarity: Mapping the medial temporal lobe networks

NeuroImage ◽  
2011 ◽  
Vol 58 (4) ◽  
pp. 1131-1138 ◽  
Author(s):  
Aimée de Vanssay-Maigne ◽  
Marion Noulhiane ◽  
Anne D. Devauchelle ◽  
Sebastian Rodrigo ◽  
Sonia Baudoin-Chial ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Encoding And Retrieval

scholarly journals Neural and behavioral correlates of episodic memory are associated with temporal discounting in older adults

2019 ◽  
Author(s):  
Karolina M. Lempert ◽  
Dawn J. Mechanic-Hamilton ◽  
Long Xie ◽  
Laura E.M. Wisse ◽  
Robin de Flores ◽  
...  
Keyword(s):  
Older Adults ◽  
Individual Differences ◽  
Episodic Memory ◽  
Temporal Lobe ◽  
Cortical Thickness ◽  
Medial Temporal Lobe ◽  
Structural Integrity ◽  
Temporal Discounting ◽  
Risk Tolerance ◽  
Trade Offs

AbstractWhen facing decisions involving trade-offs between smaller, sooner and larger, delayed rewards, people tend to discount the value of future rewards. There are substantial individual differences in this tendency toward temporal discounting, however. One neurocognitive system that may underlie these individual differences is episodic memory, given the overlap in the neural circuitry involved in imagining the future and remembering the past. Here we tested this hypothesis in older adults, including both those that were cognitively normal and those with amnestic mild cognitive impairment (MCI). We found that performance on neuropsychological measures of episodic memory retrieval was associated with temporal discounting, such that people with better memory discounted delayed rewards less. This relationship was specific to episodic memory and temporal discounting, since executive function (another cognitive ability) was unrelated to temporal discounting, and episodic memory was unrelated to risk tolerance (another decision-making preference). We also examined cortical thickness and volume in medial temporal lobe regions critical for episodic memory. Entorhinal cortical thickness was associated with reduced temporal discounting, with episodic memory performance partially mediating this association. The inclusion of MCI participants was critical to revealing these associations between episodic memory and entorhinal cortical thickness and temporal discounting. These effects were larger in the MCI group, reduced after controlling for MCI status, and statistically significant only when including MCI participants in analyses. Overall, these findings suggest that individual differences in temporal discounting are driven by episodic memory function, and that a decline in medial temporal lobe structural integrity may impact temporal discounting.

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