scholarly journals Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells

Blood ◽  
2017 ◽  
Vol 129 (26) ◽  
pp. 3428-3439 ◽  
Author(s):  
Mathew G. Angelos ◽  
Paige N. Ruh ◽  
Beau R. Webber ◽  
Robert H. Blum ◽  
Caitlin D. Ryan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Aryl Hydrocarbon Receptor ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Aryl Hydrocarbon ◽  
Small Molecule Inhibition ◽  
Receptor Inhibition ◽  
Key Points

Key Points Small-molecule inhibition and CRISPR/Cas9 deletion of AHR promote early hematoendothelial cell differentiation from hESCs. AHR inhibition enhances the differentiation of cNK cells from hESCs whereas AHR hyperactivation supports development of ILC3s.

scholarly journals Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

2012 ◽  
Vol 30 (7) ◽  
pp. 715-720 ◽  
Author(s):  
Stuart M Chambers ◽  
Yuchen Qi ◽  
Yvonne Mica ◽  
Gabsang Lee ◽  
Xin-Jun Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Developmental Timing ◽  
Small Molecule Inhibition

scholarly journals Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells

Stem Cells ◽  
2018 ◽  
Vol 36 (7) ◽  
pp. 1004-1019 ◽  
Author(s):  
Amy Leung ◽  
Elizabeth Zulick ◽  
Nicholas Skvir ◽  
Kim Vanuytsel ◽  
Tasha A. Morrison ◽  
...  
Keyword(s):  
Stem Cells ◽  
Aryl Hydrocarbon Receptor ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Receptor Signaling ◽  
Aryl Hydrocarbon ◽  
Definitive Hematopoiesis

scholarly journals Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

2017 ◽  
Vol 35 (2) ◽  
pp. 154-163 ◽  
Author(s):  
Yuchen Qi ◽  
Xin-Jun Zhang ◽  
Nicolas Renier ◽  
Zhuhao Wu ◽  
Talia Atkin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Cortical Neurons ◽  
Human Pluripotent Stem Cells ◽  
Small Molecule Inhibition

Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells

2016 ◽  
pp. 1G.6.1-1G.6.18 ◽  
Author(s):  
Santosh Mathapati ◽  
Richard Siller ◽  
Agata A.R. Impellizzeri ◽  
Max Lycke ◽  
Karianne Vegheim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells

scholarly journals Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

2015 ◽  
Vol 4 (5) ◽  
pp. 939-952 ◽  
Author(s):  
Richard Siller ◽  
Sebastian Greenhough ◽  
Elena Naumovska ◽  
Gareth J. Sullivan
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Hepatocyte Differentiation
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