Comparative randomized study of cerebral blood flow after long-term administration of pentoxifylline and co-dergocrine mesylate in patients with chronic cerebrovascular disease

1985 ◽  
Vol 9 (7) ◽  
pp. 475-479 ◽  
Author(s):  
A. Hartmann
1982 ◽  
Vol 56 (2-3) ◽  
pp. 357-364 ◽  
Author(s):  
Hisao Tachibana ◽  
Fumio Gotoh ◽  
Shin-Ichiro Ebihara ◽  
Hiroyuki Okayasu ◽  
Yasuhisa Kitagawa ◽  
...  

Angiology ◽  
1988 ◽  
Vol 39 (11) ◽  
pp. 934-941 ◽  
Author(s):  
Shotai Kobayashi ◽  
Shuhei Yamaguchi ◽  
Kazunori Okada ◽  
Mitsuhiro Kitani ◽  
Kazuya Yamashita ◽  
...  

1987 ◽  
Vol 26 (05) ◽  
pp. 192-197 ◽  
Author(s):  
T. Kreisig ◽  
P. Schmiedek ◽  
G. Leinsinger ◽  
K. Einhäupl ◽  
E. Moser

Using the 133Xe-DSPECT technique, quantitative measurements of regional cerebral blood flow (rCBF) were performed before and after provocation with acetazolamide (Diamox) i. v. in 32 patients without evidence of brain disease (normals). In 6 cases, additional studies were carried out to establish the time of maximal rCBF increase which was found to be approximately 15 min p. i. 1 g of Diamox increases the rCBF from 58 ±8 at rest to 73±5 ml/100 g/min. A Diamox dose of 2 g (9 cases) causes no further rCBF increase. After plotting the rCBF before provocation (rCBFR) and the Diamox-induced rCBF increase (reserve capacity, Δ rCBF) the regression line was Δ rCBF = −0,6 x rCBFR +50 (correlation coefficient: r = −0,77). In normals with relatively low rCBF values at rest, Diamox increases the reserve capacity much more than in normals with high rCBF values before provocation. It can be expected that this concept of measuring rCBF at rest and the reserve capacity will increase the sensitivity of distinguishing patients with reversible cerebrovascular disease (even bilateral) from normals.


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