scholarly journals Does lipid lowering therapy improve calf muscle perfusion and cellular metabolism in peripheral arterial disease?

2009 ◽  
Vol 11 (S1) ◽  
Author(s):  
Amy M West ◽  
Justin D Anderson ◽  
Frederick H Epstein ◽  
Craig H Meyer ◽  
Klaus D Hagspiel ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Cellular Metabolism ◽  
Arterial Disease ◽  
Calf Muscle ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Muscle Perfusion ◽  
Lowering Therapy ◽  
Peripheral Arterial

Lipid-Lowering Therapy in Patients With Peripheral Arterial Disease: Are Guidelines Being Met?

2005 ◽  
Vol 80 (4) ◽  
pp. 494-498 ◽  
Author(s):  
Daniel G. Federman ◽  
Dana C. Ranani ◽  
Robert S. Kirsner ◽  
Dawn M. Bravata
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Lowering Therapy ◽  
Peripheral Arterial

Lipid-Lowering Therapy in Patients with Peripheral Arterial Disease

2005 ◽  
Vol 10 (2) ◽  
pp. 145-147 ◽  
Author(s):  
Stella S. Daskalopoulou ◽  
Vasilios G. Athyros ◽  
George Hamilton ◽  
Dimitri P. Mikhailidis
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Lowering Therapy ◽  
Peripheral Arterial

scholarly journals The effect of intensified lipid-lowering therapy on long-term prognosis in patients with peripheral arterial disease

2007 ◽  
Vol 45 (5) ◽  
pp. 936-943 ◽  
Author(s):  
Harm H.H. Feringa ◽  
Stefanos E. Karagiannis ◽  
Virginie H. van Waning ◽  
Eric Boersma ◽  
Olaf Schouten ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Lowering Therapy ◽  
Long Term Prognosis ◽  
Peripheral Arterial

Lipid-Lowering Therapy in Patients with Peripheral Arterial Disease

2004 ◽  
Vol 9 (4) ◽  
pp. 271-277 ◽  
Author(s):  
Ramin Ebrahimi ◽  
Jahandar R. Saleh ◽  
Edward J. Toggart ◽  
Baubac Hayatdavoudi ◽  
Christopher J. Wolf ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Lowering Therapy ◽  
Peripheral Arterial

Abstract 3427: Uncoupling of Skeletal Muscle Perfusion and Metabolism in Peripheral Arterial Disease

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Justin D Anderson ◽  
Frederick H Epstein ◽  
Craig H Meyer ◽  
Klaus D Hagspiel ◽  
Hongkun Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Magnetic Resonance ◽  
Peripheral Arterial Disease ◽  
Cellular Metabolism ◽  
Tissue Perfusion ◽  
Arterial Disease ◽  
Calf Muscle ◽  
Peak Exercise ◽  
Muscle Perfusion ◽  
Peripheral Arterial

Introduction Studies suggests that limb hemodynamics do not correlate with functional capacity in patients with peripheral arterial disease (PAD). Alterations in microcirculatory function and muscle metabolism are postulated to account for part of this inconsistency. We sought to further characterize the relationship between macrovascular obstruction, tissue perfusion and cellular metabolism in patients with PAD. Methods Sixty-two patients with mild-to-moderate PAD (35 males, mean age±S.D. 65±11 years) had their most symptomatic leg studied (resting ankle-brachial index (ABI) 0.68±0.13). To assess macrovascular disease, a runoff magnetic resonance angiogram was segmentally scored (MRAi) according to the number and degree of arterial stenoses distal to the aorta. A calf muscle perfusion index (PI) was measured at peak exercise with a magnetic resonance imaging (MRI) compatible pedal ergometer using first pass gadolinium-enhanced MRI. PI was defined as the ratio of slopes of calf muscle tissue perfusion to arterial input. 31 Phosphorus MR spectroscopy measured calf muscle phosphocreatine recovery time constant (PCr) immediately after peak exercise. Correlations between ABI, MRAi, PI, and PCr were examined by Pearson’s correlation coefficient. Results Mean MRAi was 0.97±0.74, PI was 0.45±0.15, and PCr was 73.1±30.0 sec. For reference, values in normal subjects are 0, 0.69±0.17 and 34.7±16.6 sec, respectively. The ABI correlated with PI (r=0.46, p<0.001), inversely with MRAi (r=−0.39, p<0.005) and modestly inversely with PCr (r=−0.27, p = 0.05). The MRAi showed a trend towards an inverse correlation with PI (r=−0.27, p<0.06), but did not correlate with PCr (p = 0.29). PCr likewise did not correlate with PI (p=0.85). Conclusions In mild to moderate PAD, lower limb blood pressure relates to macrovascular obstruction and both calf muscle perfusion and metabolism at peak exercise. However, calf muscle perfusion does not correlate with cellular metabolism as determined by PCr recovery at peak exercise. Thus, there is uncoupling between calf muscle perfusion and metabolism, supporting the concept that factors independent of blood flow and intrinsic to skeletal muscle are critical in PAD.

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