scholarly journals Integrated treatment of first episode psychosis with online training (e-learning): study protocol for a randomised controlled trial

Trials ◽  
2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Sara Barbeito ◽  
Patricia Vega ◽  
Sonia Ruiz de Azua ◽  
Vicent Balanza- Martinez ◽  
Francesc Colom ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Online Training ◽  
First Episode Psychosis ◽  
Integrated Treatment ◽  
First Episode ◽  
Learning Study ◽  
Episode Psychosis ◽  
E Learning ◽  
Randomised Controlled

scholarly journals HORYZONS trial: protocol for a randomised controlled trial of a moderated online social therapy to maintain treatment effects from first-episode psychosis services

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e024104 ◽  
Author(s):  
Mario Alvarez-Jimenez ◽  
Sarah Bendall ◽  
Peter Koval ◽  
Simon Rice ◽  
Daniela Cagliarini ◽  
...  
Keyword(s):  
Social Media ◽  
Randomised Controlled Trial ◽  
Social Functioning ◽  
Controlled Trial ◽  
First Episode Psychosis ◽  
First Episode ◽  
Online Social Media ◽  
Regular Care ◽  
Episode Psychosis ◽  
Randomised Controlled

IntroductionSpecialised early intervention services have demonstrated improved outcomes in first-episode psychosis (FEP); however, clinical gains may not be sustained after patients are transferred to regular care. Moreover, many patients with FEP remain socially isolated with poor functional outcomes. To address this, our multidisciplinary team has developed a moderated online social media therapy (HORYZONS) designed to enhance social functioning and maintain clinical gains from specialist FEP services. HORYZONS merges: (1) peer-to-peer social networking; (2) tailored therapeutic interventions; (3) expert and peer-moderation; and (4) new models of psychological therapy (strengths and mindfulness-based interventions) targeting social functioning. The aim of this trial is to determine whether following 2 years of specialised support and 18-month online social media-based intervention (HORYZONS) is superior to 18 months of regular care.Methods and analysisThis study is a single-blind randomised controlled trial. The treatment conditions include HORYZONS plus treatment as usual (TAU) or TAU alone. We recruited 170 young people with FEP, aged 16–27 years, in clinical remission and nearing discharge from Early Psychosis Prevention and Intervention Centre, Melbourne. The study includes four assessment time points, namely, baseline, 6-month, 12-month and 18-month follow-up. The study is due for completion in July 2018 and included a 40-month recruitment period and an 18-month treatment phase. The primary outcome is social functioning at 18 months. Secondary outcome measures include rate of hospital admissions, cost-effectiveness, vocational status, depression, social support, loneliness, self-esteem, self-efficacy, anxiety, psychological well-being, satisfaction with life, quality of life, positive and negative psychotic symptoms and substance use. Social functioning will be also assessed in real time through our Smartphone Ecological Momentary Assessment tool.Ethics and disseminationMelbourne Health Human Research Ethics Committee (2013.146) provided ethics approval for this study. Findings will be made available through scientific journals and forums and to the public via social media and the Orygen website.Trial registration numberACTRN12614000009617; Pre-results.

OPUS project: A randomised controlled trial of integrated psychiatric treatment in first episode psychosis

2003 ◽  
Vol 60 (1) ◽  
pp. 297 ◽  
Author(s):  
M. Nordentoft ◽  
P. Jeppesen ◽  
L. Petersen ◽  
A. Thorup ◽  
M. Abel ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Psychiatric Treatment ◽  
Controlled Trial ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Randomised Controlled

scholarly journals A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis

2021 ◽  
Vol 18 (14) ◽  
pp. 7239
Author(s):  
Itxaso González-Ortega ◽  
Patricia Vega ◽  
Enrique Echeburúa ◽  
Susana Alberich ◽  
Jessica Fernández-Sevillano ◽  
...  
Keyword(s):  
Early Intervention ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
First Episode Psychosis ◽  
Clinical Treatment ◽  
Post Treatment ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Episode Psychosis ◽  
Randomised Controlled

Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The aim of this study was to compare the efficacy of a combined clinical treatment involving Cognitive Behavioural Therapy (CBT) as an adjunctive to treatment-as-usual (TAU) (CBT+TAU) versus TAU alone for FEP. Patients and methods: In this multicentre, single-blind, randomised controlled trial, 177 participants were randomly allocated to either CBT+TAU or TAU. The primary outcome was post-treatment patient functioning. Results: The CBT+TAU group showed a greater improvement in functioning, which was measured using the Global Assessment Functioning (GAF) and Functioning Assessment Short Test (FAST), compared to the TAU group post-treatment. The CBT+TAU participants exhibited a greater decline in depressive, negative, and general psychotic symptoms; a better awareness of the disease and treatment adherence; and a greater increase in brain-derived neurotrophic factor levels than TAU participants. Conclusions: Early intervention based on a combined clinical treatment involving CBT as an adjunctive to standard treatment may improve clinical and functional outcomes in FEP.

scholarly journals Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial

BMJ ◽  
2010 ◽  
Vol 341 (aug19 1) ◽  
pp. c4024-c4024 ◽  
Author(s):  
E. Y. H. Chen ◽  
C. L. M. Hui ◽  
M. M. L. Lam ◽  
C. P. Y. Chiu ◽  
C. W. Law ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Maintenance Treatment ◽  
Controlled Trial ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
One Year ◽  
Randomised Controlled
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