scholarly journals A laboratory test based on determination of cytokine profiles: a promising assay to identify exposition to contact allergens and predict the clinical outcome in occupational allergic contact dermatitis

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Valentina Bordignon ◽  
Francesca Palamara ◽  
Giorgia Altomonte ◽  
Isabella Sperduti ◽  
Mario Pietravalle ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Clinical Outcome ◽  
Laboratory Test ◽  
Allergic Contact Dermatitis ◽  
Contact Allergens ◽  
Cytokine Profiles ◽  
Allergic Contact

scholarly journals Contact-Allergic Reactions to Cosmetics

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
An Goossens
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Allergic Reactions ◽  
Hair Dyes ◽  
Contact Allergens ◽  
Contact Urticaria ◽  
The Future ◽  
Golden Standard ◽  
Hair Care ◽  
Allergic Contact

Contact-allergic reactions to cosmetics may be delayed-type reactions such as allergic and photo-allergic contact dermatitis, and more exceptionally also immediate-type reactions, that is, contact urticaria. Fragrances and preservative agents are the most important contact allergens, but reactions also occur to category-specific products such as hair dyes and other hair-care products, nail cosmetics, sunscreens, as well as to antioxidants, vehicles, emulsifiers, and, in fact, any possible cosmetic ingredient. Patch and prick testing to detect the respective culprits remains the golden standard for diagnosis, although additional tests might be useful as well. Once the specific allergens are identified, the patients should be informed of which products can be safely used in the future.

scholarly journals Role of contact allergens in chronicity and relapses of nummular eczema

2017 ◽  
Vol 3 (2) ◽  
pp. 213
Author(s):  
Renu Rattan ◽  
Gita R. Tegta ◽  
Vinay Shanker ◽  
Ghanshyam K. Verma ◽  
Anuj Sharma ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Environmental Conditions ◽  
Significant Risk ◽  
Contact Allergens ◽  
Hilly Region ◽  
International Contact ◽  
Exogenous Factors ◽  
Allergic Contact ◽  
Nummular Eczema

<p class="abstract"><strong>Background:</strong> Endogenous eczemas are often complicated by exogenous factors like environment and contact allergens. Nummular eczema, a variant of endogenous eczema is no exception to this. Our study aimed at investigating the incidence of allergic contact dermatitis and finding offending agent responsible for chronicity or relapsing course of nummular eczema in patients from a hilly region with cold and dry environmental conditions<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> Forty patients of nummular eczema with a mean age of 39.1±19 years were patch tested with the Indian Standard Patch Test Series. Positive reactions were graded as per recommendations of International contact dermatitis research group.<strong></strong></p><p class="abstract"><strong>Results:</strong> Twenty one out of forty patch tested patients showed positive reactions. The most common allergens were found to be: fragrance mix in seven (17.5%) patients, nickel in five (12.5%) patients, PPD in three (7.5%) patients and gentamicin in two (5%) patients. Sensitivity to thiuram mix, black rubber mix, P. tert. butylphenol formaldehyde, neomycin, benzocaine and chinoform was observed in one patient each (2.5% each)<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> Patients of nummular eczema of a hilly region are at a significant risk of developing allergic contact dermatitis owing to xerosis due to dry environmental conditions. This results in chronic nature of their disease. Patch testing should be considered in such patients and avoidance of offending allergens can improve their quality of life<span lang="EN-IN">.</span></p>

scholarly journals INVESTIGATION OF THE CHEMICAL COMPOSITION AND EFFICIENCY OF SEED OIL OF SPINDLE TREE (EUONYMUS EUROPAEA L.) ON THE MODEL OF NON-ALLERGIC DERMATITIS

2018 ◽  
Vol 3 ◽  
pp. 45-54
Author(s):  
Olha Vrubel ◽  
Igor Nektegaev ◽  
Volodymyr Antonyuk
Keyword(s):  
Fatty Acids ◽  
Gas Chromatography ◽  
Chemical Composition ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Silica Gel ◽  
Seed Oil ◽  
Anti Inflammatory ◽  
Allergic Contact

The aim of the research was to study the chemical composition and effectiveness of the seed oil of Spindle tree (Euonymus europaea L.) on the non-allergic contact dermatitis model. The oil was obtained by the extraction by petroleum ether from the seeds. The analysis of fatty acids and determination of their quantitative content was carried out using gas chromatography. Determination of carotenoids and tocopherols content in fatty oils was carried out after chromatography on a silica gel column. Investigation of anti-inflammatory action of the Spindle tree seed oil on white rats was carried. Determination of biochemical parameters of blood plasma was performed on the semi-automatic biochemical analyzer BS3000M (Poland). The yield of oil was 20–28 % of the weight of the seeds. Nine fatty acids were identified in the oil by the gas chromatography, among which 4 are unsaturated (oleic, palmitoleic, linoleic and linolenic), which together make up 87.79 % of all fatty acids from this oil. Spindle tree oil contains 26±5 mg – % carotenoids and 40±5 mg – % tocopherols, which were separated by chromatography on a silica gel column. There were no symptoms of intoxication with the introduction of Spindle tree oil in the stomach of rats and it can be classified in the 4 the grade of danger in accordance with GOST 12.1.005-88. The anti-inflammatory activity of Spindle tree oil in comparison with the oil of Sea buckthorn on the model of non-allergic contact dermatitis was weaker, but sufficient to recommend it for the treatment of skin diseases in ointments.

scholarly journals Common Contact Sensitizers among Patients with Hand Eczema: A Multicenter-Study in Nepal

2016 ◽  
Vol 14 (1) ◽  
pp. 14-17
Author(s):  
S. Bhattarai ◽  
A. Rijal ◽  
S. Agrawal
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Test ◽  
Patch Testing ◽  
Potassium Dichromate ◽  
College Teaching ◽  
Hand Eczema ◽  
Contact Allergens ◽  
Allergic Contact

Introduction: Allergic contact dermatitis in Nepal is not an uncommon disorder. Patch testing is a well established method of diagnosing allergic contact dermatitis. Patients with contact dermatitis are well known to have impaired quality of life which often leads to frequent dermatological consultations.Objective: Lack of data from Nepal has prompted us to undertake this study with the aims to know the frequency of allergic contact dermatitis and the commonest contact allergens among the patients with Hand eczema attending the out-patient department of dermatology, B.P. Koirala Institute of Health Sciences and Kathmandu Medical College Teaching Hospital.Material and Methods: A total of 256 patients were included in the study. Out of them 195 with hand eczema agreed to participate and undergo patch testing. The antigens used included the Indian standard series of patch test allergens approved by Contact and Occupational Dermatoses Forum of India.Results: Hundred and ten cases (56.4%) were patch test positive (PTP) at 48 as well as 96 hours to at least one allergen. PTP was seen more commonly in females. The most common allergen in females was nickel sulphate followed by cobalt chloride, gentamicin and mercapto mix while males were positive to potassium dichromate, followed by epoxy resin, fragrance mix and nickel sulphate.Conclusion: Patch testing has proved a useful tool for the detection of allergic contact dermatitis and for identification of contact allergens. When positive reactions correlate with environmental exposure the test usually assists the physician in establishing the cause of dermatitis, hence treating the patients and improving their quality of life.Nepal Journal of Dermatology, Venereology & Leprology, Vol.14(1) 2016, pp.14-17

scholarly journals The European Baseline Series in Romania: Results of Patch Testing in Contact Dermatitis and Determination of the Most Frequently Awareness in Adult Patients

2019 ◽  
Vol 70 (4) ◽  
pp. 1337-2341 ◽  
Author(s):  
Maria-Magdalena Constantin ◽  
Stefana Bucur ◽  
Clara Matei ◽  
Iuliana Elena Nita ◽  
Traian Constantin
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Patch Testing ◽  
Potassium Dichromate ◽  
Contact Allergy ◽  
Demographic Data ◽  
Positive Patch Test ◽  
Post Test ◽  
Allergic Contact

In Romania, data on patch testing are lacking and the significance and applicability of the European baseline series (EBS) needs to be evaluated. The aim of the study was to examine the prevalence of contact allergy to the EBS and to determine the most common post-test sensitization occurred in the population of patients with suspected allergic contact dermatitis in Romania. Demographic data were collected from 252 patients with suspected allergic contact dermatitis. Pacients were patch tested with 28-allergen EBS.The positive patch test was observed in 80.16% patients. The most prevalent contact allergens were nickel sulphate (15.08%), fragrance mix I & II (13.10%) and potassium dichromate (9.52%). Differences in sensitization prevalences to some allergens of the EBS compared with other European countries were recognized. The current EBS is a suitable diagnostic tool for contact allergy in Romania.

Allergic Contact Dermatitis in Children

1993 ◽  
Vol 14 (6) ◽  
pp. 240-243 ◽  
Author(s):  
Peter A. Hogan ◽  
William L. Weston
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Pediatric Population ◽  
Skin Surface ◽  
Healthy Children ◽  
Age Group ◽  
Contact Allergens ◽  
Pediatric Age Group ◽  
American Children ◽  
Allergic Contact

Definition Allergic contact dermatitis (ACD) is an inflammatory reaction of the skin that follows percutaneous absorption of antigen from the skin surface and recruitment of previously sensitized, antigen-specific T lymphocytes into the skin. Epidemiology In the pediatric age group, ACD can involve either sex and manifest as early as the first week of life. A recent review of several European and US studies found that ACD may account for up to 20% of cases of dermatitis in the 0- to 14-year-old age group. Although the incidence and prevalence of the disease in the general pediatric population is unknown, epicutaneous patch testing of randomly selected and otherwise healthy children revealed that 13% to 20% were allergic to one or more common antigens, suggesting that at least 20% of children in the general population theoretically are at risk of developing ACD. When one considers poison ivy or poison oak as contact allergens prevalent in certain areas of North America, the likelihood of allergic contact dermatitis may be much higher. Pediatricians should recognize that children are sensitized to contact allergens early in life, with most children being sensitized by age 5 years. The allergens most commonly responsible for allergic contact dermatitis in North American children are listed in Table 1.

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