scholarly journals Expression of catalase and retinoblastoma-related protein genes associates with cell death processes in Scots pine zygotic embryogenesis

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Jaana Vuosku ◽  
Suvi Sutela ◽  
Johanna Kestilä ◽  
Anne Jokela ◽  
Tytti Sarjala ◽  
...  
Keyword(s):  
Cell Death ◽  
Scots Pine ◽  
Zygotic Embryogenesis ◽  
Related Protein

scholarly journals Neuroprotection by Histone Deacetylase-Related Protein

2006 ◽  
Vol 26 (9) ◽  
pp. 3550-3564 ◽  
Author(s):  
Brad E. Morrison ◽  
Nazanin Majdzadeh ◽  
Xiaoguang Zhang ◽  
Aaron Lyles ◽  
Rhonda Bassel-Duby ◽  
...  
Keyword(s):  
Cell Death ◽  
Histone Deacetylase ◽  
Neuronal Death ◽  
Histone Deacetylases ◽  
Essential Feature ◽  
Gene Promoter ◽  
Related Protein ◽  
Phosphatidylinositol 3 Kinase ◽  
Histone Deacetylase 1 ◽  
H3 Acetylation

ABSTRACT The expression of histone deacetylase-related protein (HDRP) is reduced in neurons undergoing apoptosis. Forced reduction of HDRP expression in healthy neurons by treatment with antisense oligonucleotides also induces cell death. Likewise, neurons cultured from mice lacking HDRP are more vulnerable to cell death. Adenovirally mediated expression of HDRP prevents neuronal death, showing that HDRP is a neuroprotective protein. Neuroprotection by forced expression of HDRP is not accompanied by activation of the phosphatidylinositol 3-kinase-Akt or Raf-MEK-ERK signaling pathway, and treatment with pharmacological inhibitors of these pathways fails to inhibit the neuroprotection by HDRP. Stimulation of c-Jun phosphorylation and expression, an essential feature of neuronal death, is prevented by HDRP. We found that HDRP associates with c-Jun N-terminal kinase (JNK) and inhibits its activity, thus explaining the inhibition of c-Jun phosphorylation by HDRP. HDRP also interacts with histone deacetylase 1 (HDAC1) and recruits it to the c-Jun gene promoter, resulting in an inhibition of histone H3 acetylation at the c-Jun promoter. Although HDRP lacks intrinsic deacetylase activity, treatment with pharmacological inhibitors of histone deacetylases induces apoptosis even in the presence of ectopically expressed HDRP, underscoring the importance of c-Jun promoter deacetylation by HDRP-HDAC1 in HDRP-mediated neuroprotection. Our results suggest that neuroprotection by HDRP is mediated by the inhibition of c-Jun through its interaction with JNK and HDAC1.

scholarly journals The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death

Cell Calcium ◽  
2012 ◽  
Vol 51 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Masahiro Katano ◽  
Tomohiro Numata ◽  
Kripamoy Aguan ◽  
Yuji Hara ◽  
Shigeki Kiyonaka ◽  
...  
Keyword(s):  
Cell Death ◽  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Related Protein ◽  
Trpm2 Channel

scholarly journals Lipoprotein Receptor-Related Protein-1 Mediates Amyloid-β-Mediated Cell Death of Cerebrovascular Cells

2007 ◽  
Vol 171 (6) ◽  
pp. 1989-1999 ◽  
Author(s):  
Micha M.M. Wilhelmus ◽  
Irene Otte-Höller ◽  
Jos J.J. van Triel ◽  
Robert Veerhuis ◽  
Marion L.C. Maat-Schieman ◽  
...  
Keyword(s):  
Cell Death ◽  
Amyloid Β ◽  
Lipoprotein Receptor ◽  
Related Protein ◽  
Lipoprotein Receptor Related Protein

Patterning during somatic embryogenesis in Scots pine in relation to polar auxin transport and programmed cell death

2011 ◽  
Vol 109 (3) ◽  
pp. 391-400 ◽  
Author(s):  
Malin Abrahamsson ◽  
Silvia Valladares ◽  
Emma Larsson ◽  
David Clapham ◽  
Sara von Arnold
Keyword(s):  
Cell Death ◽  
Somatic Embryogenesis ◽  
Programmed Cell Death ◽  
Scots Pine ◽  
Auxin Transport ◽  
Polar Auxin Transport

scholarly journals SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

2013 ◽  
Vol 32 (11) ◽  
pp. 1514-1528 ◽  
Author(s):  
Chun Guo ◽  
Keri L Hildick ◽  
Jia Luo ◽  
Laura Dearden ◽  
Kevin A Wilkinson ◽  
...  
Keyword(s):  
Cell Death ◽  
Related Protein
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