scholarly journals Protease inhibitor concentrations in the saliva of individuals experiencing oral dryness

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kenkichi Yamamoto ◽  
Makiko Hiraishi ◽  
Mai Haneoka ◽  
Hidetake Fujinaka ◽  
Yoshitaka Yano
Keyword(s):  
Protease Inhibitor ◽  
Protease Inhibitors ◽  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Subjective Perception ◽  
Common Symptom ◽  
Healthy Individuals ◽  
Oral Dryness ◽  
The Relationship

Abstract Background Oral dryness is a common symptom that may interfere with swallowing, chewing, and taste. The most common reason for oral dryness is hyposalivation. Some individuals experiencing oral dryness do not have hyposalivation, however, and the reverse is also true. Here, we focused on healthy individuals with a lower salivary flow rate and evaluated the relationship between the perception of oral dryness and salivary parameters to clarify the cause underlying the perception of oral dryness. Methods A total of 59 participants were divided into 2 groups with a lower or higher salivary flow rate according to the median salivary flow rate. In participants with a lower salivary flow rate, we assessed salivary bacterial counts, protease activities, protein concentrations, oral parameters, and the subjective perception of oral dryness. Results Protease activities and concentrations of protease inhibitors such as cystatin-D and cystatin-SA in the saliva of participants experiencing oral dryness were significantly higher and lower, respectively, than in those not experiencing oral dryness, even though no difference in the salivary flow rate was detected. Salivary cystatin-D and cystatin-SA concentrations correlated negatively with salivary protease activities. Conclusions The composition of salivary protease inhibitors and increased protease activities affect the subjective perception of oral dryness.

scholarly journals Variations of salivary flow rates in Brazilian school children

2006 ◽  
Vol 20 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Sandra Regina Torres ◽  
Marcio Nucci ◽  
Estevão Milanos ◽  
Renata Pessoa Pereira ◽  
Alessandra Massaud ◽  
...  
Keyword(s):  
Public Schools ◽  
Health Status ◽  
Flow Rate ◽  
School Children ◽  
Medical Records ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Healthy Individuals ◽  
Flow Rates ◽  
Whole Saliva

The salivary flow rate (SFR) in healthy individuals may vary according to different factors. There is a scarcity of studies from different geographical areas that analyze SFR variations in children. The aim of this study was to verify stimulated salivary flow rate (SFR) variations in 6 to 12-year-old children, from four different public schools of Rio de Janeiro and correlate these data to gender, age, type of dentition, and health status. Clinical data were taken from the children's medical records that were kept at those schools. Oral examination and sialometry were performed in every child. Salivary flow rate was obtained by chewing-stimulated whole saliva under standard conditions. There were significant differences in SFR according to age (p = 0.0003). Six and 12-year-old children showed the lowest SFR, and when they were excluded from the analysis, no significant differences were found (p = 0.21). There were also significant differences in SFR among children from different public schools (p = 0.0009). The gender did not show any correlation to SFR, even when children were stratified by age (p = 0.36). Correlation between SFR and deciduous, mixed or permanent dentition was not found as well. These results show that the analyzed clinical variables did not seem to influence SFR in this children population.

On the Relationship between the Rate of Salivary Flow and Salivary Fluoride Clearance

2015 ◽  
Vol 49 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Ralph M. Duckworth ◽  
S. Jones
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Time Of Application ◽  
Saliva Flow Rate ◽  
Whole Saliva ◽  
Observed Behaviour ◽  
Saliva Flow ◽  
Unstimulated Whole Saliva ◽  
The Relationship

The amount of fluoride retained in the mouth following the application of dentifrices, mouthwashes, etc. may be important in determining their anticaries efficacy. In this study we investigated the relationship between the salivary flow rate and salivary fluoride clearance. Ten adults tested six mouthrinses, consisting of aqueous sodium fluoride solutions (0.013, 0.026 mol/l) with and without added sodium chloride (1.28 mol/l) or sucrose (0.44 mol/l), in a randomised order. Prior to each test, subjects swallowed, rinsed for 2 min with 2 ml water and then expectorated into a preweighed container to obtain a measure of initial saliva flow rate. Next, the procedure was repeated using one of the test rinses. Finally, samples of unstimulated whole saliva were collected for up to 3 h after each mouthrinse application and analysed for fluoride. Salivary fluoride concentrations were significantly lower after application of mouthrinses that contained either sucrose or NaCl, both of which compounds markedly enhanced salivary flow, than after the use of corresponding mouthrinses without any additive. Area under the salivary fluoride clearance curve (AUC) values were inversely correlated with salivary flow rate on an individual basis (p < 0.01). The observed behaviour could not be completely attributed to treatment dilution by saliva at the time of application.

scholarly journals Higher Masticatory Performance and Higher Number of Chewing Strokes Increase Retronasal Aroma

2021 ◽  
Vol 8 ◽  
Author(s):  
Jumpei Okawa ◽  
Kazuhiro Hori ◽  
Tasuku Yoshimoto ◽  
Simonne E. Salazar ◽  
Takahiro Ono
Keyword(s):  
Surface Area ◽  
Flow Rate ◽  
Statistical Significance ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Masticatory Performance ◽  
Explanatory Variables ◽  
Performance Group ◽  
Gummy Jelly ◽  
The Relationship

Mastication is a physiological process whereby food is comminuted and mixed with saliva to form a swallowable bolus; it is also the initial process for retronasal aroma that is released from foods to receptors in the nose. However, the influence of mastication state on retronasal aroma is poorly understood. The purpose of this study was to investigate the relationship between aroma concentration and factors related to mastication state. The study design was an analytical observational study. Twelve male volunteers (age, 26.5 ± 2.7 years) were recruited and divided into five and seven participants in the low and high masticatory performance groups, respectively. The stimulated salivary flow rate was measured while participants chewed paraffin wax. First, an odor sensor was placed in the nostril, and the aroma concentration was measured over time as participants chewed an orange-flavored gummy jelly standardized for masticatory performance assessment until swallowing; chewing strokes were counted to determine swallowing thresholds. Next, participants were instructed to chew the gummy jelly for a certain number of strokes (i.e., 50 or 100% of swallowing thresholds, as well as 30 strokes) and expectorate the jelly without swallowing. The surface area of comminuted jelly at 30 chewing strokes was defined as masticatory performance. Maximum and slope of aroma concentration, surface area, number of chewing strokes, and stimulated salivary flow rate were compared between low and high masticatory performance groups. Statistical significance was set at α = 0.05. At 30 chewing strokes, the maximum aroma concentration and the slope were significantly greater in the high masticatory performance group than in the low masticatory performance group. There was a positive correlation between the maximum aroma concentration and the number of chewing strokes with aroma release in both groups. No significant correlation was found between the maximum aroma concentration and the stimulated salivary flow rate. However, multiple regression analysis (with aroma concentration as a dependent variable) showed that the increase in surface area, the number of chewing strokes, and the stimulated salivary flow rate were significant explanatory variables. The results suggested that retronasal aroma was influenced by mastication state and salivary flow rate during chewing.

scholarly journals Correlation Between Clinical Oral Dryness Score and Salivary Flow Rates in Active and Passive Smokers

2021 ◽  
Vol 10 (02) ◽  
pp. 120-123
Author(s):  
Seeme Nigar ◽  
Sobia Hassan ◽  
Sidra Fahim ◽  
Ahmed Bin Khalid ◽  
Faisal Salim
Keyword(s):  
Flow Rate ◽  
Smoking Status ◽  
Saliva Sample ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Significant Difference ◽  
Oral Dryness ◽  
The Mean ◽  
Potential Factors ◽  
Oral Dryness Feeling

Objective: To evaluate the mean clinical oral dryness score (CODs) and salivary flow rate (SFR) in subjects exposed to active and passive smoking. The secondary aim was to determine the correlation between CODs and SFR and potential factors associated with CODs and SFR in our subjects. Study Design and Setting: The clinical observational study was conducted at the Outpatient department of oral diagnosis at Altamash Institute of Dental Medicine, Karachi from Jan 2019-Jul 2019. Methodology: A total of 217 participants of ages 15 – 80years coming for routine dental checkup of either gender were included. A thorough oral examination was performed for all the subjects. A non-stimulated saliva sample was collected from the oral cavity of subjects in a graduated container. The salivary flow rate was noted in ml/min for 5 minutes. Assessment of oral dryness/hypo-salivation was examined through CODs (clinical oral dryness score).The data were analyzed using SPSS software version 23. Results: The mean COD score and SFR were calculated as 1 and 0.42 ml/5min respectively. The Pearson’s correlation between COD score and SFR level was calculated as -0.281 (negative correlation) such as the SFR significantly decreased when the COD score increased (p<0.05). The age, gender, smoking status, betel quid and areca nut consumption showed statistically significant difference in mean COD score and SFR levels (p<0.05). Conclusion: Salivary flow rate was significantly decreased with increase in COD score thus having an implication on oral dryness feeling in these participants.

scholarly journals Hubungan Laju Alir dan Viskositas Saliva dengan Tingkat Kecekatan Gigi Tiruan Penuh pada Pasien Rumah Sakit Gigi dan Mulut Universitas Andalas

2016 ◽  
Vol 4 (2) ◽  
pp. 59-66
Author(s):  
Eni Rahmi ◽  
Sevty Agustin ◽  
Arymbi Pujiastuty
Keyword(s):  
Flow Rate ◽  
Significant Relationship ◽  
Salivary Flow ◽  
Complete Denture ◽  
Salivary Flow Rate ◽  
Cross Sectional ◽  
Denture Base ◽  
Cross Sectional Design ◽  
The Relationship ◽  
Mandibular Complete Denture

The most common complaint reported by patients in denture wearing is loose denture, caused by lack of retention. In the complete denture wearing, saliva plays an important role in retention. A well-fitting denture base to supporting tissues and the presence of adequate border seals will provide optimal denture retention. This condition can be achieved if it is supported by adequate volume, flow, and consistency of saliva. The purpose of this study is to determine the relationship between flow rate and viscosity of saliva with complete denture retention in Andalas Dental Collage and Hospital. This study used a cross sectional design. Thirty patients of complete denture wearers at the Andalas Dental Collage and Hospital were included in this study. Samples were selected through consecutive sampling method. Data were collected by using medical records, saliva viscosity assesstment, salivary flow rate measurement, and complete denture retention examination. Data were analyzed by Mann Whitney tes with p< 0,05. There was a significant relationship between salivary flow rate and maxillary complete denture retention (p= 0,002) and there was a significant relationship between saliva viscosity and maxillary complete denture retention (p= 0,002). However there was no relationship between salivary flow rate and mandibular complete denture retention (p= 0.101) and there was no relationship between saliva viscosity and mandibular complete denture retention (p= 0,223). The conclusion of this study was that the flow rate and viscosity of saliva was associated with maxillary complete denture retention yet was not associated with mandibular denture retention.

scholarly journals SALIVARY PROFILE AND IDENTIFICATION OF EXISTING CANDIDA sp OF AN INSTITUTIONALIZED ELDERLY POPULATION IN JAKARTA

2013 ◽  
Vol 17 (4) ◽  
pp. 334-338
Author(s):  
Febrina Rahmayanti ◽  
Yuniardini Septorini Wimardhani ◽  
Indriasti Wardhany
Keyword(s):  
Flow Rate ◽  
Elderly Population ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Normal Range ◽  
Institutionalized Elderly ◽  
Candida Sp ◽  
Salivary Ph ◽  
Oral Dryness ◽  
Oral Symptom

Saliva plays an important role to protect oral and dental health, in maintenance oral microflora balance. In elderly, disease, and medications usually influence the saliva. The purpose of this preliminary study was to investigate salivary profile, oral symptoms of dryness, and existing of Candida sp of an institutionalized elderly in Jakarta, Twenty seven (27) elderly (17 men and 10 women) were examined in a cross sectional study. Unstimulated whole saliva was collected for 5 minutes, according to published protocol, and then salivary flow rate and pH were measured. Candida sp were cultured in CHROM agar. The yeasts were counted and identified. Oral symptom or complaints of oral dryness, and burning or itching were recorded with an interview. Data of systemic conditions and medication the used were obtained from the medical record. Eighteen (66.7%) CHROM agar plates were Candida sp positive cultured, and about 61.1% subjects’ salivary pH were below normal range. Twenty one (77.8%) subjects had oral symptom and complain about oral dryness, even thought the salivary flow rate were in normal range. In this study, C.albicans is not the most frequently found colonized. About 72% were identified not C.albicans. This study suggests that, in elderly which salivary pH was below normal range have greater opportunistic infected by Candida sp. It can be concluded that, the result did not confirm a significant difference between subjects’ data and salivary profile concentration. The mycological finding Candida albicans is not the most frequently found colonized in this elderly population. Further study which lagger elderly population and might give deeper insights of salivary profile in this population.

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