scholarly journals Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Maelán Fontes-Villalba ◽  
Staffan Lindeberg ◽  
Yvonne Granfeldt ◽  
Filip K. Knop ◽  
Ashfaque A. Memon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fasting Plasma ◽  
Diabetes Diet ◽  
Palaeolithic Diet ◽  
Plasma Leptin

scholarly journals The frequency of Tim-3 on circulating Tfh cells was increased in type 2 diabetes mellitus patients

2020 ◽  
Vol 18 ◽  
pp. 205873922098280
Author(s):  
Shuai Guo ◽  
Xujie Yu ◽  
Limei Wang ◽  
Jing Jing ◽  
Yuanyuan Sun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
High Glucose ◽  
C Peptide ◽  
Glucose Levels ◽  
Tfh Cells ◽  
Fasting Plasma ◽  
Healthy Donors

Type 2 diabetes mellitus (T2DM) is a chronic, low-grade inflammation disease. T follicular helper (Tfh) cells and T cell immunoglobulin and mucin domain 3 (Tim-3) are implicated in many immune diseases. This study aims to explore whether Tim-3 expression on Tfh cells is associated with T2DM progression. White blood cells (WBCs) were harvested from 30 patients with T2DM and 20 healthy donors. The abundance of circulating Tfh cells (cTfh) and the frequency of Tim-3 were analyzed by flow cytometry. Levels of fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1C), and fasting plasma C-peptide were measured. Body mass index (BMI) and diabetes duration were also recorded. Patients with T2DM had higher numbers of cTfh cells. In addition, cTfh cells showed a negative correlation with HbA1C and diabetes duration, a positive correlation with fasting plasma C-peptide. The frequency of Tim-3 on cTfh cells was higher among T2DM patients compared with healthy donors. The in vitro experiment showed that high glucose levels increased the abundance cTfh cells but had no effect on Tim-3 expression. Our results suggest that cTfh cells and associated Tim-3 frequency may contribute to the progression of T2DM, and high glucose levels may influence cTfh cells directly.

Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study

Diabetologia ◽  
2014 ◽  
Vol 57 (8) ◽  
pp. 1601-1610 ◽  
Author(s):  
Martine Vaxillaire ◽  
Loïc Yengo ◽  
Stéphane Lobbens ◽  
Ghislain Rocheleau ◽  
Elodie Eury ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Homeostasis ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Genetic Risk ◽  
Risk Scores ◽  
Genetic Risk Scores ◽  
Fasting Plasma

1006-P: Progression to Type 2 Diabetes Despite a Baseline Fasting Plasma Glucose ≤ 80 mg/dl in a Population-Based Cohort

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 1006-P
Author(s):  
AOIFE M. EGAN ◽  
CHRISTINA WOOD-WENTZ ◽  
KENT R. BAILEY ◽  
ADRIAN VELLA
Keyword(s):  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Population Based ◽  
Fasting Plasma
Sign in / Sign up

Export Citation Format

Share Document