scholarly journals Tetrahedral DNA nanostructures for effective treatment of cancer: advances and prospects

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jianqin Yan ◽  
Xiaohui Zhan ◽  
Zhuangzhuang Zhang ◽  
Keqi Chen ◽  
Maolong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Effective Treatment ◽  
Molecular Diagnostics ◽  
High Stability ◽  
Biological Imaging ◽  
Chemotherapeutic Drugs ◽  
Dna Nanostructures ◽  
Imaging Probes ◽  
Application Potential

AbstractRecently, DNA nanostructures with vast application potential in the field of biomedicine, especially in drug delivery. Among these, tetrahedral DNA nanostructures (TDN) have attracted interest worldwide due to their high stability, excellent biocompatibility, and simplicity of modification. TDN could be synthesized easily and reproducibly to serve as carriers for, chemotherapeutic drugs, nucleic acid drugs and imaging probes. Therefore, their applications include, but are not restricted to, drug delivery, molecular diagnostics, and biological imaging. In this review, we summarize the methods of functional modification and application of TDN in cancer treatment. Also, we discuss the pressing questions that should be targeted to increase the applicability of TDN in the future. Graphical Abstract

Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery

Biomaterials ◽  
2019 ◽  
Vol 195 ◽  
pp. 1-12 ◽  
Author(s):  
Kyoung-Ran Kim ◽  
Seong Jae Kang ◽  
A-Young Lee ◽  
Dohyeon Hwang ◽  
Miri Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Targeted Drug Delivery ◽  
Dna Nanostructures ◽  
In Vivo Screening ◽  
Targeted Drug

scholarly journals Click and photo-release dual-functional nucleic acid nanostructures

2019 ◽  
Vol 55 (65) ◽  
pp. 9709-9712 ◽  
Author(s):  
Vibhav A. Valsangkar ◽  
Arun Richard Chandrasekaran ◽  
Lifeng Zhuo ◽  
Song Mao ◽  
Goh Woon Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Click Chemistry ◽  
Dna Nanostructures ◽  
Dual Functional

DNA nanostructures are useful in drug delivery, with cargos attached via click chemistry and released using light-based triggers.

scholarly journals Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1967
Author(s):  
Ziwen Dai ◽  
Juan Li ◽  
Yongfang Lin ◽  
Zhigang Wang ◽  
Yang Huang
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Dna Aptamers ◽  
Dna Nanostructures ◽  
Dna Strands ◽  
Targeting Ability

We designed a functional drug delivery system based solely on DNA. The whole system was built with only four DNA strands. Cyclization of DNA strands excluded the formation of byproducts. DNA aptamers were equipped to endow triangular DNA nanostructures with targeting ability. The homogeneity of materials enabled not only facile construction but also convenient loading of nucleic acid-based drugs with much ease.

Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery

2015 ◽  
Vol 16 (14) ◽  
pp. 1650-1659 ◽  
Author(s):  
Carla Sardo ◽  
Emanuela Craparo ◽  
Calogero Fiorica ◽  
Gaetano Giammona ◽  
Gennara Cavallaro
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Microwave Synthesis

scholarly journals Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3067
Author(s):  
Mustafa A. Jihad ◽  
Farah T. M. Noori ◽  
Majid S. Jabir ◽  
Salim Albukhaty ◽  
Faizah A. AlMalki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Grain Size ◽  
Cell Wall ◽  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Nucleic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nigella Sativa ◽  
Seed Extract

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.

scholarly journals A glucose meter interface for point-of-care gene circuit-based diagnostics

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Evan Amalfitano ◽  
Margot Karlikow ◽  
Masoud Norouzi ◽  
Katariina Jaenes ◽  
Seray Cicek ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Synthetic Biology ◽  
Molecular Diagnostics ◽  
Point Of Care ◽  
Low Cost ◽  
Gene Circuit ◽  
Reporter Systems ◽  
Glucose Meter ◽  
Pandemic Response ◽  
Glucose Output

AbstractRecent advances in cell-free synthetic biology have given rise to gene circuit-based sensors with the potential to provide decentralized and low-cost molecular diagnostics. However, it remains a challenge to deliver this sensing capacity into the hands of users in a practical manner. Here, we leverage the glucose meter, one of the most widely available point-of-care sensing devices, to serve as a universal reader for these decentralized diagnostics. We describe a molecular translator that can convert the activation of conventional gene circuit-based sensors into a glucose output that can be read by off-the-shelf glucose meters. We show the development of new glucogenic reporter systems, multiplexed reporter outputs and detection of nucleic acid targets down to the low attomolar range. Using this glucose-meter interface, we demonstrate the detection of a small-molecule analyte; sample-to-result diagnostics for typhoid, paratyphoid A/B; and show the potential for pandemic response with nucleic acid sensors for SARS-CoV-2.

scholarly journals Bicyclic 1,3a,6a-Triazapentalene Chromophores: Synthesis, Spectroscopy and Their Use as Fluorescent Sensors and Probes

Chemosensors ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 16
Author(s):  
Yingchun Wang ◽  
Tomas Opsomer ◽  
Wim Dehaen
Keyword(s):  
Stokes Shift ◽  
Substituent Effects ◽  
Visible Spectrum ◽  
Fluorescent Sensors ◽  
Biological Imaging ◽  
Fluorescent Imaging ◽  
Fluorescence Properties ◽  
Imaging Probes ◽  
Synthetic Methodologies ◽  
Aromatic Heterocyclic

The 1,3a,6a-triazapentalene (TAP) is an aromatic heterocyclic fluorescent dye with interesting features such as its small size, large Stokes shift, solvatochromism, and emission wavelengths that are spread across the visible spectrum. TAPs have been synthesized via different synthetic strategies involving click−cyclization−aromatization domino reactions, gold-catalyzed cyclization of propargyl triazoles or triazolization of acetophenones. As a result, TAPs with diverse substitution patterns were obtained, showing varying fluorescence properties. Based on these properties, several TAPs have been selected and studied as fluorescent imaging probes in living cells and as sensors. This mini review provides an overview of the research on the bicyclic TAPs and does not comment on the literature about benzo or otherwise fused systems. The synthetic methodologies for the preparation of TAPs, the substituent effects on the fluorescence properties, and the behavior of the TAP core as an element of biological imaging probes and sensors are discussed.

Polymeric micelles as drug delivery systems in cancer: challenges and opportunities

Nanomedicine ◽  
2021 ◽  
Author(s):  
Swati Biswas
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Clinical Translation ◽  
Current Status ◽  
Chemotherapeutic Drugs ◽  
Challenges And Opportunities

Tweetable abstract Micelles are nanocarriers for hydrophobic chemotherapeutic drugs. This editorial discusses the current status of preclinical micellar research and sheds light on the possibility of their clinical translation.

Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes

2015 ◽  
Vol 60 (14) ◽  
pp. 1272-1280 ◽  
Author(s):  
Bingbing Lin ◽  
Hongying Su ◽  
Rongrong Jin ◽  
Danyang Li ◽  
Changqiang Wu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Imaging Probes
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