scholarly journals Emerging role of a novel small non-coding regulatory RNA: tRNA-derived small RNA

ExRNA ◽  
2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Fangfang Jin ◽  
Zhigang Guo
Keyword(s):  
Small Rna ◽  
Current Knowledge ◽  
Future Research ◽  
Regulatory Rna ◽  
Biological Functions ◽  
Research Directions ◽  
Non Coding Rna ◽  
Future Research Directions ◽  
Non Coding Rnas

Abstract The discovery of small non-coding RNAs, such as miRNA and piRNA, has dramatically changed our understanding of the role RNA plays in organisms. Recent studies show that a novel small non-coding RNA generated from cleavage of tRNA or pre-tRNA, called tRNA-derived small RNA (tsRNA), serves as a new regulator of gene expression. tsRNA has been determined participate in regulating some specific physiological and pathological processes. Although knowledge regarding the biological roles of miRNA and piRNA is expanding, whether tsRNAs play similar roles remains poorly understood. Here, we review the current knowledge regarding the mechanisms of action and biological functions of tsRNAs in intracellular, extracellular and intergenerational inheritance, and highlight the potential application of tsRNAs in human diseases, and present the current problems and future research directions.

Cybercafés and Youth Development

2012 ◽  
pp. 422-433
Author(s):  
Sebnem Cilesiz
Keyword(s):  
Youth Development ◽  
Current Knowledge ◽  
Public Access ◽  
Future Research ◽  
Research Directions ◽  
The World ◽  
The Status ◽  
Future Research Directions ◽  
The Relationship

Among various forms of public access to computers and the Internet, cybercafés are a specific phenomenon around the world. Predominantly, they are frequented by young people, thus attracting the attention of educators and policymakers. Despite the worldwide prominence of cybercafés, very little research has examined youth’s activities at cybercafés and the outcomes of their participation. This chapter reviews the literature on cybercafés in general, followed by the status of current knowledge about the role of cybercafés in social interaction, informal learning, and youth development. The chapter concludes with suggestions for future research directions on the relationship between cybercafés and youth development.

Fire Fighting and Emergency Responding

2019 ◽  
pp. 641-661
Author(s):  
Mark Wiggins ◽  
Jaime Auton ◽  
Melanie Taylor
Keyword(s):  
Mental Models ◽  
Current Knowledge ◽  
Theoretical Perspective ◽  
Future Research ◽  
Operational Environment ◽  
Research Directions ◽  
Experimental Approaches ◽  
Future Research Directions ◽  
Research Initiatives

This chapter examines the study of expertise in the context of firefighting and emergency responding. The distinction is made between descriptive and experimental approaches, and the need to develop and validate a theoretical perspective that explains expertise in situations that are high dynamic, uncertain, and where the consequences of errors can be significant. Gaps in current knowledge are identified, including the mechanisms by which expertise is acquired and maintained, how it can be measured accurately and reliably, and how and when the capacity for expertise degrades over time and in absence of exposure to emergency conditions. The outcomes of existing research initiatives are discussed, with an emphasis on accurate and precise mental models that are acquired through active interaction within the operational environment. The role of cues and cue utilization are also considered as triggers to activate mental models. Future research directions that will ensure the development of a comprehensive understanding of the nature expertise in firefighting and emergency responding are proposed.

scholarly journals Long Non-coding RNA: An Emerging Contributor and Potential Therapeutic Target in Renal Fibrosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Weiping Xia ◽  
Yao He ◽  
Yu Gan ◽  
Bo Zhang ◽  
Guoyu Dai ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Molecular Mechanisms ◽  
Pathological Process ◽  
Major Type ◽  
Future Research ◽  
Non Coding Rna ◽  
Future Research Directions ◽  
Non Coding Rnas ◽  
Long Non Coding Rna

Renal fibrosis (RF) is a pathological process that culminates in terminal renal failure in chronic kidney disease (CKD). Fibrosis contributes to progressive and irreversible decline in renal function. However, the molecular mechanisms involved in RF are complex and remain poorly understood. Long non-coding RNAs (lncRNAs) are a major type of non-coding RNAs, which significantly affect various disease processes, cellular homeostasis, and development through multiple mechanisms. Recent investigations have implicated aberrantly expressed lncRNA in RF development and progression, suggesting that lncRNAs play a crucial role in determining the clinical manifestation of RF. In this review, we comprehensively evaluated the recently published articles on lncRNAs in RF, discussed the potential application of lncRNAs as diagnostic and/or prognostic biomarkers, proposed therapeutic targets for treating RF-associated diseases and subsequent CKD transition, and highlight future research directions in the context of the role of lncRNAs in the development and treatment of RF.

scholarly journals Movement Economy in Soccer: Current Data and Limitations

Sports ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 124 ◽  
Author(s):  
Filippo Dolci ◽  
Nicolas H. Hart ◽  
Andrew Kilding ◽  
Paola Chivers ◽  
Ben Piggott ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Current Data ◽  
Soccer Players ◽  
Future Research ◽  
Physical Factors ◽  
Match Play ◽  
Research Directions ◽  
Running Performance ◽  
Future Research Directions

Soccer is an intermittent team-sport, where performance is determined by a myriad of psychological, technical, tactical, and physical factors. Among the physical factors, endurance appears to play a key role into counteracting the fatigue-related reduction in running performance observed during soccer matches. One physiological determinant of endurance is movement economy, which represents the aerobic energy cost to exercise at a given submaximal velocity. While the role of movement economy has been extensively examined in endurance athletes, it has received little attention in soccer players, but may be an important factor, given the prolonged demands of match play. For this reason, the current review discusses the nature, impact, and trainability of movement economy specific to soccer players. A summary of current knowledge and limitations of movement economy in soccer is provided, with an insight into future research directions, to make this important parameter more valuable when assessing and training soccer players’ running performance.

Interpersonal Psychotherapy for the Treatment of Eating Disorders

2010 ◽  
pp. 347-372 ◽  
Author(s):  
Marian Tanofsky-Kraff ◽  
Denise E. Wilfley
Keyword(s):  
Anorexia Nervosa ◽  
Clinical Care ◽  
Interpersonal Psychotherapy ◽  
Future Research ◽  
Cognitive Behavior ◽  
Research Directions ◽  
Routine Clinical Care ◽  
Interpersonal Factors ◽  
Future Research Directions

Interpersonal psychotherapy (IPT) is a focused, time-limited treatment that targets interpersonal problem(s) associated with the onset and/or maintenance of EDs. IPT is supported by substantial empirical evidence documenting the role of interpersonal factors in the onset and maintenance of EDs. IPT is a viable alternative to cognitive behavior therapy for the treatment of bulimia nervosa and binge eating disorder. The effectiveness of IPT for the treatment of anorexia nervosa requires further investigation. The utility of IPT for the prevention of obesity is currently being explored. Future research directions include enhancing the delivery of IPT for EDs, increasing the availability of IPT in routine clinical care settings, exploring IPT adolescent and parent–child adaptations, and developing IPT for the prevention of eating and weight-related problems that may promote full-syndrome EDs or obesity.

The Effectiveness of Family-Supportive Supervisors: The Moderating Role of Employees’ Collectivistic Self-Construal

2020 ◽  
Vol 51 (6) ◽  
pp. 442-455
Author(s):  
Peng Wang ◽  
Zhengxue Luo ◽  
Zhen Wang
Keyword(s):  
Self Determination Theory ◽  
Employee Perceptions ◽  
Future Research ◽  
Research Directions ◽  
Self Construal ◽  
Member Exchange ◽  
Future Research Directions ◽  
Work Family ◽  
Work Family Enrichment

Built upon conservation of resource theory and self-determination theory, this study explores boundary conditions under which family-supportive supervisors (FSSs) influence employee-perceived leader–member exchange (LMX) and work–family enrichment (WFE). Findings from this research reveal that FSSs positively relate to employee perceptions of LMX and WFE. Employees’ collectivistic self-construals moderate the effect of FSSs on LMX but not on WFE. Implications and future research directions are discussed.

Cardiovascular Comorbidities of Psoriasis and Psoriatic Arthritis: A Report from the GRAPPA 2012 Annual Meeting

2013 ◽  
Vol 40 (8) ◽  
pp. 1434-1437 ◽  
Author(s):  
April W. Armstrong ◽  
Joel M. Gelfand ◽  
Wolf-Henning Boehncke ◽  
Ehrin J. Armstrong
Keyword(s):  
Psoriatic Arthritis ◽  
Annual Meeting ◽  
Tumor Necrosis ◽  
Panel Discussion ◽  
Future Research ◽  
Research Directions ◽  
Cardiovascular Comorbidities ◽  
Future Research Directions ◽  
Necrosis Factor

At the 2012 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) in Stockholm, Sweden, several GRAPPA members led a panel discussion on cardiovascular (CV) comorbidities of psoriasis and psoriatic arthritis (PsA). The panelists discussed the role of insulin resistance in the pathophysiology of psoriasis, the possible effect of tumor necrosis factor inhibitors on CV comorbidities, and the effect of 12/23 monoclonal antibodies on CV outcomes. The panelists also addressed how lessons from CV comorbidity research could be applied to other areas of comorbidity research in psoriasis and PsA and identified future research directions in this area.

scholarly journals Melatonin in plants: what we know and what we don’t

2021 ◽  
Vol 5 ◽  
Author(s):  
Zixin Zhang ◽  
Yang Zhang
Keyword(s):  
Abiotic Stresses ◽  
Growth And Development ◽  
Current Knowledge ◽  
Future Research ◽  
Signal Transduction Pathways ◽  
Biotic And Abiotic Stresses ◽  
Research Directions ◽  
Genetic Characteristics ◽  
Future Research Directions ◽  
Biosynthesis Regulation

Abstract Melatonin is an endogenous micromolecular compound of indoleamine with multiple physiological functions in various organisms. In plants, melatonin is involved in growth and development, as well as in responses to biotic and abiotic stresses. Furthermore, melatonin functions in phytohormone-mediated signal transduction pathways. There are multiple melatonin biosynthesis pathways, and the melatonin content in plants is greatly affected by intrinsic genetic characteristics and external environmental factors. Although melatonin biosynthesis has been extensively studied in model plants, it remains uncharacterized in most plants. This article focuses on current knowledge on the biosynthesis, regulation and application of melatonin, particularly for fruit quality and preservation. In addition, it highlights the links between melatonin and other hormones, as well as future research directions.

Value Co-Creation in Cloud Services

2013 ◽  
pp. 74-91 ◽  
Author(s):  
Ammar Rashid ◽  
William Yu Chung Wang ◽  
Felix B. Tan
Keyword(s):  
Service Providers ◽  
Practical Experience ◽  
Cloud Services ◽  
Future Research ◽  
Research Directions ◽  
Technical Aspects ◽  
Creation Process ◽  
Managerial Implications ◽  
Future Research Directions

In recent years, there has been considerable interest in cloud services in academic literature. Most research in this area has focused on the technical aspects of designing and implementing cloud services, with few studies focusing on understanding the value of cloud services and the processes by which consumer and service providers engage each other to co-create these services. This chapter explains the co-creation processes, and, the role of consumer in the value co-creation process of cloud services. It incorporates extant marketing and information systems literature, industry reports, and practical experience reflections to highlight the significance of cloud services. The drivers of co-creation are explored with the description of co-creation processes and the underlying factors involved in value co-creation of cloud services. The chapter concludes by outlining the opportunities associated with the development of cloud services, noting future research directions and discussing academic and managerial implications.

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