Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships

2006 ◽  
Vol 79 (5) ◽  
pp. 881-895 ◽  
Author(s):  
Ariel Mizrahi ◽  
Yevgeny Berdichevsky ◽  
Yelena Ugolev ◽  
Shahar Molshanski-Mor ◽  
Yael Nakash ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Structure Function ◽  
Phagocyte Nadph Oxidase ◽  
Nadph Oxidase Complex

scholarly journals Functional modules and expression of mouse p40 phox and p67phox, SH3-domain-containing proteins involved in the phagocyte NADPH oxidase complex

1998 ◽  
Vol 251 (3) ◽  
pp. 573-582 ◽  
Author(s):  
Kazuhito Mizuki ◽  
Kenji Kadomatsu ◽  
Kenichiro Hata ◽  
Takashi Ito ◽  
Qi-Wen Fan ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Sh3 Domain ◽  
Functional Modules ◽  
Phagocyte Nadph Oxidase ◽  
Nadph Oxidase Complex

scholarly journals Impaired respiratory burst contributes to infections in PKCδ-deficient patients

2021 ◽  
Vol 218 (9) ◽  
Author(s):  
Anna-Lena Neehus ◽  
Kunihiko Moriya ◽  
Alejandro Nieto-Patlán ◽  
Tom Le Voyer ◽  
Romain Lévy ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Lupus Erythematosus ◽  
Autosomal Recessive ◽  
Neutrophil Extracellular Trap ◽  
Ros Production ◽  
Childhood Onset ◽  
Phagocyte Nadph Oxidase ◽  
Kinase C ◽  
Nadph Oxidase Complex ◽  
Low Levels

Patients with autosomal recessive protein kinase C δ (PKCδ) deficiency suffer from childhood-onset autoimmunity, including systemic lupus erythematosus. They also suffer from recurrent infections that overlap with those seen in patients with chronic granulomatous disease (CGD), a disease caused by defects of the phagocyte NADPH oxidase and a lack of reactive oxygen species (ROS) production. We studied an international cohort of 17 PKCδ-deficient patients and found that their EBV-B cells and monocyte-derived phagocytes produced only small amounts of ROS and did not phosphorylate p40phox normally after PMA or opsonized Staphylococcus aureus stimulation. Moreover, the patients’ circulating phagocytes displayed abnormally low levels of ROS production and markedly reduced neutrophil extracellular trap formation, altogether suggesting a role for PKCδ in activation of the NADPH oxidase complex. Our findings thus show that patients with PKCδ deficiency have impaired NADPH oxidase activity in various myeloid subsets, which may contribute to their CGD-like infectious phenotype.

scholarly journals An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex.

1994 ◽  
Vol 269 (19) ◽  
pp. 13752-13755 ◽  
Author(s):  
P. Finan ◽  
Y. Shimizu ◽  
I. Gout ◽  
J. Hsuan ◽  
O. Truong ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Sh3 Domain ◽  
Phagocyte Nadph Oxidase ◽  
Nadph Oxidase Complex

How Important are S100A8/S100A9 Calcium Binding Proteins for the Activation of Phagocyte NADPH Oxidase, Nox2

2009 ◽  
Vol 8 (4) ◽  
pp. 282-289 ◽  
Author(s):  
Sylvie Berthier ◽  
Athan Baillet ◽  
Marie-Helene Paclet ◽  
Philippe Gaudin ◽  
Francoise Morel
Keyword(s):  
Nadph Oxidase ◽  
Calcium Binding ◽  
Binding Proteins ◽  
Calcium Binding Proteins ◽  
Phagocyte Nadph Oxidase

scholarly journals Apocynin prevents GM-CSF-induced-ERK1/2 activation and -neutrophil survival independently of its inhibitory effect on the phagocyte NADPH oxidase NOX2

2020 ◽  
Vol 177 ◽  
pp. 113950
Author(s):  
Coralie Pintard ◽  
Marwa Ben Khemis ◽  
Dan Liu ◽  
Pham My-Chan Dang ◽  
Margarita Hurtado-Nedelec ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Inhibitory Effect ◽  
Gm Csf ◽  
Phagocyte Nadph Oxidase ◽  
Neutrophil Survival

scholarly journals STIM1 for stimulation of phagocyte NADPH oxidase

Blood ◽  
2014 ◽  
Vol 123 (14) ◽  
pp. 2129-2130
Author(s):  
Richard D. Ye
Keyword(s):  
Nadph Oxidase ◽  
Phagocyte Nadph Oxidase ◽  
Stimulation Of

scholarly journals Staphylococcus aureus, phagocyte NADPH oxidase and chronic granulomatous disease

2016 ◽  
pp. fuw042 ◽  
Author(s):  
Helene Buvelot ◽  
Klara M. Posfay-Barbe ◽  
Patrick Linder ◽  
Jacques Schrenzel ◽  
Karl-Heinz Krause
Keyword(s):  
Staphylococcus Aureus ◽  
Nadph Oxidase ◽  
Chronic Granulomatous Disease ◽  
Granulomatous Disease ◽  
Phagocyte Nadph Oxidase
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