Proton Therapy in Clinical Practice: Current Clinical Evidence

2007 ◽  
Vol 25 (8) ◽  
pp. 965-970 ◽  
Author(s):  
Michael Brada ◽  
Madelon Pijls-Johannesma ◽  
Dirk De Ruysscher
Keyword(s):  
Clinical Practice ◽  
Proton Therapy ◽  
Clinical Evidence

scholarly journals FROM EVIDENCE TO IMPLEMENTATION: HOW SYSTEMS DESIGN CAN FORESEE COMPLEX HEALTHCARE INTERVENTIONS

2020 ◽  
Vol 1 ◽  
pp. 1891-1900
Author(s):  
A. N. Feldman ◽  
F. Patou ◽  
A. M. Maier
Keyword(s):  
Clinical Practice ◽  
Clinical Evidence ◽  
Complex Interventions ◽  
Systems Design ◽  
Routine Clinical Practice ◽  
Hybrid Design ◽  
Engineer Research ◽  
Organisational Effectiveness ◽  
Effective Implementation ◽  
Healthcare Interventions

AbstractHow can we design and engineer research that leads to the development and effective implementation of complex healthcare interventions? We advocate for a systems design-based approach when initiating clinical research to anticipate the proposition of complex interventions. Using cognitive care as an example, we investigate how hybrid design-inspired methodologies can promote organisational effectiveness and how strong clinical evidence can support successful conceptualisation and uptake of novel interventions into routine clinical practice.

SU-GG-T-455: Experimental Evaluation of Irradiated Dose in Clinical Practice for Proton Therapy

2010 ◽  
Vol 37 (6Part23) ◽  
pp. 3291-3291
Author(s):  
T Matsuura ◽  
K Hotta ◽  
R Kohno ◽  
T Nishio ◽  
S Kameoka ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Proton Therapy ◽  
Experimental Evaluation

Oxford Handbook of Key Clinical Evidence

2016 ◽  
Keyword(s):  
Clinical Practice ◽  
Statistical Methods ◽  
Clinical Evidence ◽  
Trial Data ◽  
Evidence Based ◽  
Medical Studies ◽  
Surgical Practice ◽  
One Stop ◽  
Based Medicine ◽  
Selection Of

Key trials have been selected for their relevance to clinical practice, allowing the reader to quickly access some of the most fundamental issues that influence their day-to-day activities. The Handbook covers all major medical and surgical specialties, with a new section on paediatrics added for the second edition. Introductory chapters have been included on the development of evidence-based medicine, giving uninitiated readers the tools required to critically analyse and understand medical studies. Complex trials have been distilled to key relevant facts, for quick reference and understanding. This is a comprehensive one-stop shop for medical students, trainees, and clinicians of all levels that presents key information for a selection of seminal evidence that has informed medical and surgical practice. Readers are introduced to the statistical methods and tools needed to critically analyse trial data, providing a key for the terms and statistical methods encountered in the book and within clinical research as a whole. Leading figures in the major specialties have selected and summarized some of the most important trials, while analysis of the key message and impact of the trial firmly places the evidence into a practical setting for the reader. Key study features and results are examined, while the difficulties or problems associated with the trials are outlined.

Squalene monooxygenase – a target for hypercholesterolemic therapy

2011 ◽  
Vol 392 (12) ◽  
pp. 1053-1075 ◽  
Author(s):  
Agnieszka Belter ◽  
Miroslawa Skupinska ◽  
Malgorzata Giel-Pietraszuk ◽  
Tomasz Grabarkiewicz ◽  
Leszek Rychlewski ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Evidence ◽  
Cholesterol Biosynthesis ◽  
Cardiovascular Prevention ◽  
Cost Effective ◽  
Clinical Use ◽  
Cellular Cholesterol ◽  
Squalene Monooxygenase ◽  
Hypolipidemic Drugs ◽  
Hypocholesterolemic Agents

Abstract Squalene monooxygenase catalyzes the epoxidation of C-C double bond of squalene to yield 2,3-oxidosqualene, the key step of sterol biosynthesis pathways in eukaryotes. Sterols are essential compounds of these organisms and squalene epoxidation is an important regulatory point in their synthesis. Squalene monooxygenase downregulation in vertebrates and fungi decreases synthesis of cholesterol and ergosterol, respectively, which makes squalene monooxygenase a potent and attractive target of hypercholesterolemia and antifungal therapies. Currently some fungal squalene monooxygenase inhibitors (terbinafine, naftifine, butenafine) are in clinical use, whereas mammalian enzymes’ inhibitors are still under investigation. Research on new squalene monooxygenase inhibitors is important due to the prevalence of hypercholesterolemia and the lack of both sufficient and safe remedies. In this paper we (i) review data on activity and the structure of squalene monooxygenase, (ii) present its inhibitors, (iii) compare current strategies of lowering cholesterol level in blood with some of the most promising strategies, (iv) underline advantages of squalene monooxygenase as a target for hypercholesterolemia therapy, and (v) discuss safety concerns about hypercholesterolemia therapy based on inhibition of cellular cholesterol biosynthesis and potential usage of squalene monooxygenase inhibitors in clinical practice. After many years of use of statins there is some clinical evidence for their adverse effects and only partial effectiveness. Currently they are drugs of choice but are used with many restrictions, especially in case of children, elderly patients and women of childbearing potential. Certainly, for the next few years, statins will continue to be a suitable tool for cost-effective cardiovascular prevention; however research on new hypolipidemic drugs is highly desirable. We suggest that squalene monooxygenase inhibitors could become the hypocholesterolemic agents of the future.

Proton therapy for head and neck cancer: Rationale, potential indications, practical considerations, and current clinical evidence

2011 ◽  
Vol 50 (6) ◽  
pp. 763-771 ◽  
Author(s):  
Nancy P. Mendenhall ◽  
Robert S. Malyapa ◽  
Zhong Su ◽  
Daniel Yeung ◽  
William M. Mendenhall ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Clinical Evidence

scholarly journals Vocal Fold Vibration Characteristics during SOVTE using a Vibration Simulator and Digital Kymography

2021 ◽  
Vol 26 (4) ◽  
pp. 921-932
Author(s):  
Ji Sung Kim ◽  
Seong Hee Choi ◽  
Kyoungjae Lee ◽  
Chul-Hee Choi ◽  
Soo-Geun Wang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Vocal Fold ◽  
Clinical Evidence ◽  
Vocal Tract ◽  
Voice Quality ◽  
Vibration Characteristics ◽  
Single Source ◽  
Vocal Fold Vibration ◽  
Vibration Parameters

Objectives: The purpose of this study is to investigate the characteristics of vocal fold vibration during sustained vowel /a/ phonation and various semi-occluded vocal tract exercise (SOVTEs) using a vibration simulator and digital kymography (DKG).Methods: A total of 12 normal young speakers (6 males, 6 females) aged 20-30 years participated in the study. They phonated a sustained /a/ vowel and performed SOVTE. The vocal fold vibration characteristics were measured according to the number of vibration sources (single vs. double), and vocal tract occlusion degree using a vibration simulator and DKG. Glottal gap quotient (GQ, %), speed quotient (SQ, %) and amplitude (pixel) were estimated quantitatively from the DKG image.Results: The results showed that significantly higher GQ (p = .000) and SQ (p = .000) were observed in the humming and bilabial fricative /β/ compared to open vowels. The amplitude was significantly higher in the open vowel /a/ than in humming (p = .018) and bilabial fricative /β/ (p = .003). Also, when comparing the vocal fold vibration parameters according to vibration type (single source: straw phonation vs. double source: straw phonation with water), the double source presented a significantly higher GQ (p = .000) as well as SQ (p = .008) in comparison with a single source.Conclusion: SOVTE showed a glottal gap that is different from the opened vowel /a/. It also had a longer opening of the vocal fold and a smaller amplitude than the vowel. This suggests that SOVTE may be helpful for facilitating vocal fold vibration and good voice quality in clinical practice. The current study can be meaningful in providing theoretical and clinical evidence for SOVTE.

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