Design of a Long-Acting Rivastigmine Transdermal Delivery System: Based on Computational Simulation

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Xue Han ◽  
Jingchuan Liu ◽  
Xiaoyue Hu ◽  
Wei Wang ◽  
Qing Wang
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Computational Simulation ◽  
Transdermal Delivery System ◽  
Long Acting

A statistical approach to the development of a transdermal delivery system for ondansetron

2010 ◽  
Vol 399 (1-2) ◽  
pp. 87-93 ◽  
Author(s):  
Yasuko Obata ◽  
Yuriko Ashitaka ◽  
Shingo Kikuchi ◽  
Koichi Isowa ◽  
Kozo Takayama
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Statistical Approach ◽  
Transdermal Delivery System

scholarly journals Development and In vitro Evaluation of Betahistine Adhesive-Type Transdermal Delivery System

2011 ◽  
Vol 9 (6) ◽  
Author(s):  
Ashish A Heda ◽  
Aravind R Sonawane ◽  
Gautam H Naranje ◽  
Vijay G Somani ◽  
Prashant K Puranik
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Delivery System ◽  
Adhesive Type

Transdermal Delivery Of Macromolecules Using Nanolipid Carriers

2021 ◽  
Vol 27 ◽  
Author(s):  
Sana Kalave ◽  
Bappaditya Chatterjee ◽  
Parth Shah ◽  
Ambikanandan Misra
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Low Frequency ◽  
Nanostructured Lipid Carriers ◽  
Skin Damage ◽  
Low Frequency Ultrasound ◽  
Transdermal Delivery System ◽  
Nanolipid Carriers ◽  
Transport Of Macromolecules ◽  
Frequency Ultrasound

: Skin being the largest external organ, offers an enticing procedure for transdermal drug delivery, so the drug needs to rise above the outermost layer of the skin, i.e., stratum corneum. Small molecular drug entities obeying the Lipinski rule, i.e., drugs having a molecular weight less than 500Da, high lipophilicity, and optimum polarity, are favored enough to be used on the skin as therapeutics. Skin's barrier action properties prevent the transport of macromolecules at pre-determined therapeutic rates. Notable advancement in macromolecules' transdermal delivery occurred in recent years. Scientists have opted for liposomes, the use of electroporation or, low-frequency ultrasound techniques. Some of these have shown better delivery of macromolecules at clinically beneficial rates. These physical technologies involve complex mechanisms, which may irreversibly incur skin damage. Majorly, two types of lipid-based formulations, including Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) are widely investigated as a transdermal delivery system. In this review, the concepts, mechanisms, and applications of Nanostructured Lipid Carriers that are considered feasible for transporting macromolecules via transdermal delivery system are thoroughly reviewed and presented along with their clinical perspective.

scholarly journals Design and Evaluation of Chitosan films for Transdermal delivery of Glimepiride

2018 ◽  
pp. 13-25
Author(s):  
Syed Ata Ur Rahman ◽  
Neeraj Sharma
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Inclusion Complexation ◽  
Penetration Enhancers ◽  
In Vivo Studies ◽  
Skin Barrier Function ◽  
Antidiabetic Therapy ◽  
Transdermal Delivery System ◽  
Chitosan Films

Glimepiride is a third generation oral antidiabetic sulphonylurea drug frequently prescribed to patients of type 2 diabetes. However, its oral therapy is encountered with bioavailability problems due to its poor solubility leading to irreproducible clinical response, in addition to adverse effects like dizziness and gastric disturbances. As a potential for convenient, safe and effective antidiabetic therapy, the rationale of this study was to develop a transdermal delivery system for glimepiride. Chitosan polymer was utilized in developing transdermal films for glimepiride. Chitosan has film forming ability, bioadhesive and absorption enhancing properties. Aiming at optimizing the drug delivery and circumventing the skin barrier function, inclusion complexation of glimepiride with beta-cyclodextrin (β-CyD) as well as the use of several conventional penetration enhancers were monitored for augmenting the drug flux. The physical and mechanical properties of the prepared films were investigated using tensile testing, IR spectroscopy and X-ray diffractometry. Release studies revealed adequate release rates from chitosan films. Permeation studies through full thickness rat abdominal skin were conducted. High flux values were obtained from films comprising a combination of the drug with limonene and ethanol as well as from films containing glimepiride-β-CyD complex. In vivo studies on diabetic rats for selected formulae revealed a marked therapeutic efficacy sustained for about 48 hours. The above-mentioned results shed light on feasibility of utilizing chitosan as an effective, safe transdermal delivery system for glimepiride characterized by increased patient compliance and better control of the disease.

scholarly journals Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro

2017 ◽  
Vol 34 (7) ◽  
pp. 1491-1504 ◽  
Author(s):  
Qian Zhang ◽  
Michael Murawsky ◽  
Terri LaCount ◽  
Jinsong Hao ◽  
Gerald B. Kasting ◽  
...  
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Temperature Gradients ◽  
Temperature Profiles ◽  
Transdermal Delivery System
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