Sequential in Vivo Measurement of Cerebral Intracellular Metabolites with Phosphorus-31 Magnetic Resonance Spectroscopy during Global Cerebral Ischemia and Reperfusion in Rats

Neurosurgery ◽  
1987 ◽  
Vol 21 (5) ◽  
pp. 699-708 ◽  
Author(s):  
Brian T. Andrews ◽  
Philip R. Weinstein ◽  
Max Keniry ◽  
Bryan Pereira
Keyword(s):  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Global Cerebral Ischemia ◽  
Resonance Spectroscopy ◽  
Ischemia And Reperfusion ◽  
Intracellular Metabolites ◽  
In Vivo Measurement ◽  
Cerebral Ischemia And Reperfusion

A review of in vivo 1H magnetic resonance spectroscopy of cerebral ischemia in rats

1998 ◽  
Vol 76 (2-3) ◽  
pp. 487-496 ◽  
Author(s):  
K L Malisza ◽  
P Kozlowski ◽  
J Peeling
Keyword(s):  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Lactate Concentration ◽  
Dichloroacetic Acid ◽  
Proton Nuclear Magnetic Resonance ◽  
Effect Of Temperature ◽  
Resonance Spectroscopy ◽  
Ischemic Damage

A number of metabolic alterations are initiated by cerebral ischemia including dramatic increases in lactate concentration, decreases in N-acetylaspartate, choline, and creatine concentrations, as well as changes in amino acid levels. A review of proton nuclear magnetic resonance spectroscopy studies of focal and global cerebral ischemia in rats is presented here. In particular, studies in neonatal rats have shown that a continued elevation of lactate levels without recovery after hypoxia-ischemia or a decrease in N-acetylaspartate concentration at any time are indicative of deleterious outcome. Studies of the effect of temperature on ischemic damage in a model of focal ischemia showed that outcome improved with mild hypothermia. Again, lack of recovery of lactate upon reperfusion was shown to be indicative of poor outcome. Dichloroacetic acid was used to treat rats with focal ischemic damage. Animals subjected to transient ischemia that were treated with dichloroacetic acid showed significant decreases in lactate concentration.Key words: NMR, in vivo, rat, cerebral ischemia.

scholarly journals Influence of hyperglycemia on cerebral ischemia studied by in vivo magnetic resonance spectroscopy

1988 ◽  
Vol 46 ◽  
pp. 50
Author(s):  
Yoshikazu Kurigayashi ◽  
Hiroaki Naritomi ◽  
Masahiro Sasaki ◽  
Masaru Kanashiro ◽  
Tetsuzo Tagawa ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy

scholarly journals In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate

2009 ◽  
Vol 62 (2) ◽  
pp. 307-313 ◽  
Author(s):  
Daniel M. Spielman ◽  
Dirk Mayer ◽  
Yi-Fen Yen ◽  
James Tropp ◽  
Ralph E. Hurd ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Rat Liver ◽  
Ethanol Metabolism ◽  
Resonance Spectroscopy ◽  
In Vivo Measurement
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