scholarly journals SOX2 maintains the quiescent progenitor cell state of postnatal retinal Muller glia

Development ◽  
2013 ◽  
Vol 140 (7) ◽  
pp. 1445-1456 ◽  
Author(s):  
N. Surzenko ◽  
T. Crowl ◽  
A. Bachleda ◽  
L. Langer ◽  
L. Pevny
Keyword(s):  
Progenitor Cell ◽  
Muller Glia ◽  
Müller Glia ◽  
Cell State

scholarly journals Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas

2021 ◽  
Vol 9 ◽  
Author(s):  
Raquel Lourenço ◽  
Ana S. Brandão ◽  
Jorge Borbinha ◽  
Rita Gorgulho ◽  
António Jacinto
Keyword(s):  
Progenitor Cell ◽  
Hippo Pathway ◽  
Cell Formation ◽  
Muller Glia ◽  
Müller Glia ◽  
Cell Cycle Reentry ◽  
Bona Fide ◽  
Reprogramming Factors ◽  
The Hippo Pathway ◽  
Dependent Mechanism

Vertebrates such as zebrafish have the outstanding ability to fully regenerate their retina upon injury, while mammals, including humans, do not. In zebrafish, upon light-induced injury, photoreceptor regeneration is achieved through reprogramming of Müller glia cells, which proliferate and give rise to a self-renewing population of progenitors that migrate to the lesion site to differentiate into the new photoreceptors. The Hippo pathway effector YAP was recently implicated in the response to damage in the retina, but how this transcription coactivator is integrated into the signaling network regulating Müller glia reprogramming has not yet been explored. Here, we show that Yap is required in Müller glia to engage their response to a lesion by regulating their cell cycle reentry and progenitor cell formation, contributing to the differentiation of new photoreceptors. We propose that this regulation is accomplished through a lin28a–ascl1a-dependent mechanism, bona fide Müller glia-reprogramming factors. Overall, this study presents Yap as a key regulator of zebrafish Müller glia reprogramming and consequently retina regeneration upon injury.

scholarly journals mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Soyeon Lim ◽  
You-Joung Kim ◽  
Sooyeon Park ◽  
Ji-heon Choi ◽  
Younghoon Sung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Tuberous Sclerosis Complex ◽  
Progenitor Cell ◽  
Mouse Retina ◽  
Muller Glia ◽  
Müller Glia ◽  
Retinal Progenitor ◽  
Mechanistic Target Of Rapamycin ◽  
Glycolytic Gene

Retinal progenitor cells (RPCs) divide in limited numbers to generate the cells comprising vertebrate retina. The molecular mechanism that leads RPC to the division limit, however, remains elusive. Here, we find that the hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) in an RPC subset by deletion of tuberous sclerosis complex 1 (Tsc1) makes the RPCs arrive at the division limit precociously and produce Müller glia (MG) that degenerate from senescence-associated cell death. We further show the hyperproliferation of Tsc1-deficient RPCs and the degeneration of MG in the mouse retina disappear by concomitant deletion of hypoxia-induced factor 1-a (Hif1a), which induces glycolytic gene expression to support mTORC1-induced RPC proliferation. Collectively, our results suggest that, by having mTORC1 constitutively active, an RPC divides and exhausts mitotic capacity faster than neighboring RPCs, and thus produces retinal cells that degenerate with aging-related changes.

Müller Glia-Mediated Retinal Regeneration

2021 ◽  
Author(s):  
Hui Gao ◽  
Luodan A ◽  
Xiaona Huang ◽  
Xi Chen ◽  
Haiwei Xu
Keyword(s):  
Muller Glia ◽  
Müller Glia ◽  
Retinal Regeneration

Müller glia–myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish

Glia ◽  
2021 ◽  
Author(s):  
Annelies Van Dyck ◽  
Ilse Bollaerts ◽  
An Beckers ◽  
Sophie Vanhunsel ◽  
Nynke Glorian ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Myeloid Cell ◽  
Muller Glia ◽  
Müller Glia ◽  
Adult Zebrafish ◽  
Optic Nerve Regeneration ◽  
Cell Crosstalk

d-Serine regulates CREB phosphorylation induced by NMDA receptor activation in Müller glia from the retina

2007 ◽  
Vol 427 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Mónica Lamas ◽  
Irene Lee-Rivera ◽  
Mónica Ramírez ◽  
Ana María López-Colomé
Keyword(s):  
Nmda Receptor ◽  
Receptor Activation ◽  
Muller Glia ◽  
Müller Glia ◽  
Creb Phosphorylation ◽  
Nmda Receptor Activation

Glutamate Receptor Stimulation Up-Regulates Glutamate Uptake in Human Müller Glia Cells

2016 ◽  
Vol 41 (7) ◽  
pp. 1797-1805 ◽  
Author(s):  
Ana María López-Colomé ◽  
Edith López ◽  
Orquidia G. Mendez-Flores ◽  
Arturo Ortega
Keyword(s):  
Glutamate Receptor ◽  
Glutamate Uptake ◽  
Muller Glia ◽  
Müller Glia ◽  
Receptor Stimulation ◽  
Glia Cells
Sign in / Sign up

Export Citation Format

Share Document