INFLUENCE OF EXERCISE.TRAINING ON THE CARDIOVASCULAR RESPONSE TO CENTRAL NERVOUS SYSTEM (CNS) ADMINISTRATION OF CORTICOTROPIN-RELEASING FACTOR (CRF).

1989 ◽  
Vol 21 (Supplement) ◽  
pp. S85
Author(s):  
J. M. Overton ◽  
K. C. Kregel ◽  
C. M. Tipton ◽  
D. R. Seals ◽  
L. A. Fisher
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cardiovascular Response ◽  
Corticotropin Releasing Factor

Effect of a central CRF antagonist on cardiovascular and thermoregulatory responses induced by stress or IL-1 beta

1993 ◽  
Vol 265 (4) ◽  
pp. R834-R839 ◽  
Author(s):  
T. Nakamori ◽  
A. Morimoto ◽  
N. Murakami
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Interleukin 1 ◽  
Corticotropin Releasing Factor ◽  
Mild Stress ◽  
Induced Responses ◽  
Interleukin 1 Beta ◽  
The Central Nervous System ◽  
Beta 2

We investigated the role of central corticotropin-releasing factor (CRF) in the development of cardiovascular and thermal responses induced by stress or by interleukin-1 beta (IL-1 beta) in free-moving rats. Intracerebroventricular (icv) injection of alpha-helical CRF9-41 (10 micrograms), a CRF receptor antagonist, significantly attenuated hypertension, tachycardia, and a rise in body temperature induced by cage-switch stress, a mild stress. However, icv injection of alpha-helical CRF9-41 (10 micrograms) had no effect on hypertension, tachycardia, or fever induced by intraperitoneal (ip) injection of IL-1 beta (2 micrograms/kg) or icv prostaglandin E2 (PGE2, 100 ng). In contrast, icv injection of alpha-helical CRF9-41 (10 micrograms) significantly attenuated hypertension, tachycardia, or fever induced by icv injection of IL-1 beta (20 ng). The present results suggest that central CRF has an important role in the development of the cage-switch stress-induced responses, but it does not seem to contribute to the hypertension, tachycardia, and fever induced by ip IL-1 beta or by central PGE2. However, it is possible that when IL-1 beta directly acts on the central nervous system, some of its actions are mediated by central CRF.

Effects of 2-buten-4-olide, an endogenous satiety substance, on plasma glucose, corticosterone, and catecholamines

1994 ◽  
Vol 266 (2) ◽  
pp. R413-R418 ◽  
Author(s):  
I. Matsumoto ◽  
Y. Oomura ◽  
H. Nishino ◽  
S. Nemoto ◽  
S. Aou ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Plasma Glucose ◽  
Jugular Vein ◽  
Corticotropin Releasing Factor ◽  
Dependent Manner ◽  
Indwelling Catheter ◽  
The Central Nervous System ◽  
The Right ◽  
Dose Dependent

Effects of 2-buten-4-olide (2-B4O), an endogenous satiety substance, on levels of plasma glucose, corticosterone, and catecholamines were examined in fed, conscious, and unrestrained rats. A vascular indwelling catheter was inserted into the right atrium of the animal from the jugular vein 1 wk before the experiment. Injection of 2-B4O and blood sampling were performed through the catheter in an unanesthetized condition. The levels of plasma glucose, corticosterone, epinephrine, and norepinephrine increased significantly for 2 h after the start of intravenous injection of 2-B4O in a dose-dependent manner. The increases in glucose and catecholamines induced by 2-B4O injection were abolished by bilateral splanchnicotomy (SPX) but not by pretreatment with anti-corticotropin-releasing factor (CRF) antibody. The increase in corticosterone was abolished not by the SPX but by pretreatment with anti-CRF antibody. These findings suggest that 2-B4O, endogenously produced during food deprivation, may facilitate sympathoadrenal and hypothalamopituitary-adrenal functions through the central nervous system.

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