scholarly journals Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model

2017 ◽  
Vol 81 (1) ◽  
pp. 110-118 ◽  
Author(s):  
Kazuyuki Ikeda ◽  
Yasutaka Mizoro ◽  
Tomonaga Ameku ◽  
Yui Nomiya ◽  
Shin-Ichi Mae ◽  
...  
Keyword(s):  
Stem Cell ◽  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Pluripotent Stem Cell ◽  
Disease Model ◽  
Induced Pluripotent Stem Cell ◽  
Transcriptional Analysis ◽  
Cell Disease ◽  
Intravenous Immunoglobulin Resistance ◽  
Induced Pluripotent

scholarly journals “Betwixt Mine Eye and Heart a League Is Took”: The Progress of Induced Pluripotent Stem-Cell-Based Models of Dystrophin-Associated Cardiomyopathy

2020 ◽  
Vol 21 (19) ◽  
pp. 6997 ◽  
Author(s):  
Davide Rovina ◽  
Elisa Castiglioni ◽  
Francesco Niro ◽  
Sara Mallia ◽  
Giulio Pompilio ◽  
...  
Keyword(s):  
Stem Cell ◽  
Muscular Dystrophy ◽  
Pluripotent Stem Cell ◽  
Disease Modeling ◽  
Disease Model ◽  
Induced Pluripotent Stem Cell ◽  
Patient Specific ◽  
Great Promise ◽  
Cord Injury ◽  
Induced Pluripotent

The ultimate goal of precision disease modeling is to artificially recreate the disease of affected people in a highly controllable and adaptable external environment. This field has rapidly advanced which is evident from the application of patient-specific pluripotent stem-cell-derived precision therapies in numerous clinical trials aimed at a diverse set of diseases such as macular degeneration, heart disease, spinal cord injury, graft-versus-host disease, and muscular dystrophy. Despite the existence of semi-adequate treatments for tempering skeletal muscle degeneration in dystrophic patients, nonischemic cardiomyopathy remains one of the primary causes of death. Therefore, cardiovascular cells derived from muscular dystrophy patients’ induced pluripotent stem cells are well suited to mimic dystrophin-associated cardiomyopathy and hold great promise for the development of future fully effective therapies. The purpose of this article is to convey the realities of employing precision disease models of dystrophin-associated cardiomyopathy. This is achieved by discussing, as suggested in the title echoing William Shakespeare’s words, the settlements (or “leagues”) made by researchers to manage the constraints (“betwixt mine eye and heart”) distancing them from achieving a perfect precision disease model.

P2-145: Development of an induced pluripotent stem cell (iPSC) Alzheimer's disease model using PSEN1 mutant fibroblasts

2012 ◽  
Vol 8 (4S_Part_9) ◽  
pp. P310-P310 ◽  
Author(s):  
Andrew Sproul ◽  
Samson Jacob ◽  
Michael Nestor ◽  
Serene Keilani ◽  
Ying Jean ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Disease Model ◽  
Induced Pluripotent Stem Cell ◽  
Induced Pluripotent
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