scholarly journals Hereditary angioedema and pregnancy: successful management of recurrent and frequent attacks of angioedema with C1-inhibitor concentrate, danazol and tranexamic acid – a case report

2009 ◽  
Vol 2 (3) ◽  
pp. 123-125 ◽  
Author(s):  
D S Milingos ◽  
P Madhuvrata ◽  
J Dean ◽  
A Shetty ◽  
D M Campbell
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Tranexamic Acid ◽  
Hereditary Angioedema ◽  
C1 Inhibitor ◽  
Successful Management ◽  
C1 Esterase Inhibitor ◽  
Threatening Condition ◽  
Life Threatening ◽  
Esterase Inhibitor

Hereditary angioedema (HAE) is a rare but potentially life-threatening condition caused by deficiency of C1 esterase inhibitor. It is characterized by subcutaneous swelling in any part of the skin, gastrointestinal and respiratory tracts. We present the case of a pregnant woman with known HAE that deteriorated during pregnancy with frequent attacks that were managed successfully with danazol, tranexamic acid and regular intravenous administration of C1 esterase inhibitor.

scholarly journals Hereditary angioedema caused by C1-esterase inhibitor deficiency: a case report with literature-based analysis

2019 ◽  
Vol 8 (2) ◽  
pp. 741
Author(s):  
Sufia Athar ◽  
Noureddine Korichi ◽  
Yousra Shehada Siam
Keyword(s):  
Case Report ◽  
Hereditary Angioedema ◽  
Fresh Frozen Plasma ◽  
Pregnancy And Childbirth ◽  
C1 Esterase Inhibitor ◽  
Close Observation ◽  
Fresh Frozen ◽  
Dominant Disease ◽  
Frozen Plasma ◽  
Esterase Inhibitor

Hereditary angioedema (HAE) caused by C1-esterase inhibitor deficiency is an autosomal-dominant disease caused by a mutation in the C1-inhibitor gene. It is a rare disease that is often worsened during pregnancy and childbirth. HAE, though uncommon but if untreated it may lead to maternal death.  The case report presents the successful management of a 24 years old, G2P1, with hereditary angioedema caused by C1-esterase inhibitor deficiency. This patient was managed with a multidisciplinary approach by an obstetrician, an immunologist, an anaesthesiologist and a pediatrician. She had an uneventful antenatal period, labor was induced. She had precipitate delivery and soon after delivery had a flare up of the disease. It was successfully managed with fresh frozen plasma and close observation. 

C1 Esterase Inhibitor (Human) for the Treatment of Acute Hereditary Angioedema

2011 ◽  
Vol 4 ◽  
pp. CMBD.S4090 ◽  
Author(s):  
Solange Oliveira Rodrigues Valle ◽  
Alfeu Tavares França ◽  
Regis A. Campos ◽  
Anete Sevciovic Grumach
Keyword(s):  
Quality Of Life ◽  
Rare Disease ◽  
Hereditary Angioedema ◽  
C1 Esterase Inhibitor ◽  
Genetic Deficiency ◽  
Life Threatening ◽  
Patients Experience ◽  
Tremendous Impact ◽  
Esterase Inhibitor

Hereditary angioedema (HAE) is a relatively rare disease characterized by acute episodes of swelling. These swellings can be disfiguring, painful and life-threatening. Since the symptoms occur in different areas and most patients experience a delay in their diagnosis, resulting in unnecessary suffering and dangerous situations. HAE can have a tremendous impact on the quality of life. The major genetic deficiency in this disorder is either an absent or nonfunctional C1INH which regulates the complement, fibrinolitic, kalikrein and plasmin pathways.

Sudden unexpected death due to hereditary angioedema — A case report

2021 ◽  
Vol 6 (2) ◽  
pp. 60-65
Author(s):  
S Narayanan ◽  
S Ramalingam ◽  
R Narendar
Keyword(s):  
Case Report ◽  
Mortality Rate ◽  
Hereditary Angioedema ◽  
Laryngeal Edema ◽  
Inhibitor Protein ◽  
Unexpected Death ◽  
C1 Esterase Inhibitor ◽  
First Case ◽  
C1 Esterase Inhibitor Protein ◽  
Esterase Inhibitor

Angioedema related to deficiency of the C1- esterase inhibitor protein (C1-inh) is characterized by lack of response to therapies, which include antihistamines, steroids and epinephrine. In case of laryngeal edema, mortality rate is an estimated mammoth 30 percent. The first case of such acquired form of angioedema related to the deficiency in C1- esterase inhibitor was published in 1972. In the present case, we entail details of one such case.,

Hereditary Angioedema Managed with Low-Dose Danazol and C1 Esterase Inhibitor Concentrate: A Case Report

2006 ◽  
Vol 28 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Alon D. Altman ◽  
Janice McLaughlin ◽  
Robert Schellenberg ◽  
Charles Penner ◽  
Laura Arbour ◽  
...  
Keyword(s):  
Case Report ◽  
Hereditary Angioedema ◽  
Low Dose ◽  
C1 Esterase Inhibitor ◽  
Esterase Inhibitor

Nanofiltered C1-Esterase Inhibitor for the Acute Management and Prevention of Hereditary Angioedema Attacks due to C1-Inhibitor Deficiency in Children

2013 ◽  
Vol 162 (5) ◽  
pp. 1017-1022.e2 ◽  
Author(s):  
William Lumry ◽  
Michael E. Manning ◽  
David S. Hurewitz ◽  
Mark Davis-Lorton ◽  
David Fitts ◽  
...  
Keyword(s):  
Hereditary Angioedema ◽  
Acute Management ◽  
C1 Inhibitor ◽  
C1 Inhibitor Deficiency ◽  
C1 Esterase Inhibitor ◽  
Esterase Inhibitor
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