Age-specific and gender-specific radiation risks in paediatric angiography and interventional cardiology: conversion coefficients and risk reference values

2020 ◽  
Vol 93 (1110) ◽  
pp. 20190869
Author(s):  
Angeliki Karambatsakidou ◽  
Kristoffer Steiner ◽  
Annette Fransson ◽  
Gavin Poludniowski
Keyword(s):  
Cancer Risk ◽  
Reference Values ◽  
Radiation Risk ◽  
Age Groups ◽  
Cancer Death ◽  
Age Related ◽  
Conversion Coefficients ◽  
And Gender ◽  
Cardiac Catheterizations ◽  
Gender Specific

Objectives: To estimate risk for exposure-induced cancer death (REID), organ-specific risks of exposure-induced cancer death (REIDHT) and associated conversion coefficients (CCREID:KAP=REID/kerma-area product (KAP), CCREIDHT:KAP=REIDHT/KAP) in paediatric cardiac catheterizations using data from radiation dose structured reports (RDSR). A novel risk surveillance tool consisting of age-specific and gender-specific risk reference values (RRVs) related to population cancer risk is suggested. Methods: The PCXMC v.2.0 code is used together with exposure-related information from RDSR from a cohort of 238 children to assess cancer risks and related conversion coefficients. The KAP corresponding to 1 in 1000 of increased REID is used to define age-specific and gender-specific KAP values to monitor risk in such patient cohorts, here denoted as RRVs. Results: The REID estimates ranged from below 1 up to 300 in 100,000, and the RRVs for the different age groups and gender ranged from 0.77 Gycm2 and 2.1 Gycm2 for neonates (female, male) to 11 Gycm2 and 25 Gycm2 for 15-year-olds (female, male). The CCREID:KAP and CCREIDHT:KAP decreased biexponentially with increased age, being notably higher for female patients. Conclusions: Prominent risk contributing organs were the lungs and the (female) breast. The concept of age-specific and gender-specific RRVs related to population cancer risk is introduced and is intended to be used as a supporting tool for physicians performing such interventions. Advances in knowledge: Age-related and gender-related conversion coefficients for radiation risk, CCREID:KAP and CCREIDHT:KAP, are introduced and a novel risk surveillance concept, the RRV, is suggested for paediatric cardiac catheterizations.

Age- and gender-related normative value of whole-body sagittal alignment based on 584 asymptomatic Chinese adult population from age 20 to 89

2021 ◽  
Author(s):  
Z Hu ◽  
GCW Man ◽  
KH Yeung ◽  
WH Cheung ◽  
WCW Chu ◽  
...  
Keyword(s):  
Lower Limb ◽  
Sagittal Alignment ◽  
Pearson Correlation ◽  
Age Groups ◽  
Whole Body ◽  
Normative Values ◽  
Chinese Adults ◽  
Age And Gender ◽  
Age Related ◽  
And Gender

To establish the age- and sex-related normative values of sagittal alignment in asymptomatic Chinese adults, and to investigate the changes and possible associated compensation mechanisms across age groups. 584 asymptomatic Chinese adults aged 20–89 years were recruited. Subjects were grouped according to age and gender. Whole-body standing radiographs were acquired for evaluating sagittal alignment from spine to lower limb. Sagittal parameters between gender in different age groups were compared via independent t test. Pearson correlation analysis was used to demonstrate relationships between parameters. Thoracic kyphosis (TK) increased steadily while lumbar lordosis decreased gradually in both genders. Pelvic tilt (PT) in male is greater than in female across all age groups with age related gradual increase. There were significant differences between male and female from 20s to 60s in terms of knee flexion angle (KA) and ankle dorsiflexion angle (AA), but the differences were not significant after 60s. T1 pelvic angle (TPA) was significantly correlated with spinal, pelvic and lower-limb alignment. The older group (≥50 years) had a stronger correlation of TPA with PT and KA, whereas the younger (<50 years) had stronger correlation with TK. This study comprehensively presented the normative sagittal alignment based on a large asymptomatic population, which could serve as an age- and gender-specific reference value for spine surgeons when planning for correction surgery. Age can influence the recruitment of compensation mechanism that involve more pelvic and lower limb mechanisms for elderly people.

P5309Age and gender distributions of coronary artery calcium in the Dutch adult population: preliminary results of the ImaLife study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Xia ◽  
M Rook ◽  
G J Pelgrim ◽  
J N Van Bolhuis ◽  
P M A Van Ooijen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Reference Values ◽  
Coronary Artery Calcium ◽  
Adult Population ◽  
Age Groups ◽  
Population Based ◽  
Imaging Biomarkers ◽  
Dutch Population ◽  
Age And Gender ◽  
And Gender

Abstract Background Coronary artery calcium (CAC) scoring is a promising tool for cardiovascular risk classification. Population-based reference values are important for the clinical interpretation of CAC scores. Purpose To establish standards of CAC distributions by age and gender in an unselected Dutch population, which can be used to determine reference values. Methods ImaLife (Imaging in Lifelines) is a computed tomography (CT) based substudy of the Lifelines cohort, with a primary aim to establish reference values of imaging biomarkers for early stages of coronary artery disease in adults (above 45 years old). In total, 12,000 participants will be enrolled from an unselected adult population in the northern Netherlands for CAC scoring with third generation dual-source CT. CAC is quantified with dedicated commercial software using the Agatston method. Results Included so far were 3,702 participants (57.5% females, mean age 54 years, range 45–82 years). CAC was present in 39.2% of participants, with a higher prevalence of CAC in men (55.3%) than in women (27.3%). CAC scores increased with increasing age in both genders. The percentiles of CAC scores by age and gender groups are summarized in the table. Agatston CAC score percentiles by age and gender Percentiles Women – Age, years Men – Age, years 45–49 50–54 55–59 60–64 65∼ 45–49 50–54 55–59 60–64 65∼ N 505 634 719 260 10 355 473 543 185 18 25th 0 0 0 0 0 0 0 0 1 75 50th 0 0 0 0 4 0 1 6 22 556 75th 0 0 6 33 386 6 21 72 129 751 90th 4 26 77 120 1037 49 154 242 500 1803 Conclusion This preliminary result presents CAC distribution by age and gender in a middle-aged unselected Dutch population. Compared with the Heinz Nixdorf Recall study, CAC scores in our cohort for both genders were lower in the 5-year age groups between 45 and 64 years. Based on the overall data, expected within 2 years, reference values of CAC for the Dutch population can be established.

scholarly journals Imagery Ability and Imagery Perspective Preference: A Study of Their Relationship and Age- and Gender-Related Changes

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Karen P. Y. Liu ◽  
Monica Lai ◽  
Shirley S. M. Fong ◽  
Michelle Bissett
Keyword(s):  
Age Groups ◽  
Real Life ◽  
Clinical Intervention ◽  
Preference Test ◽  
Knee Extension ◽  
Imagery Ability ◽  
Age Related ◽  
Temporal Congruence ◽  
Imagery Perspective ◽  
And Gender

This study examined if imagery ability (i.e., vividness and temporal congruence between imagined and executed knee extensions) and imagery perspective preference were affected by ageing and gender. Ninety-four participants, 31 young, 43 intermediate, and 20 older adults completed the Vividness of Movement Imagery Questionnaire-2 and a knee extension temporal congruence test to reflect on their imagery ability and an imagery perspective preference test. Male participants had a better imagery ability than the female participants (F 4,85=2.84, p=.029, η2=.118). However, significant age-related changes in imagery ability were not found in the three age groups. Change in imagery perspective preference with a trend towards an external imagery perspective was observed with ageing (F 3,89=3.16, p=.028, η2=.096) but not between male and female. The results suggest that imagery ability may be preserved with ageing. As individuals age, their preference for using an imagery perspective shifts from a more internal to a more external perspective. This understanding is important when designing future imagery research and real-life application or clinical intervention.

scholarly journals Cerebrospinal Fluid Protein Concentrations in Children: Age-related Values in Patients without Disorders of the Central Nervous System

2000 ◽  
Vol 46 (3) ◽  
pp. 399-403 ◽  
Author(s):  
Daniel Biou ◽  
Jean-François Benoist ◽  
Claire Nguyen-Thi ◽  
Xuan Huong ◽  
Philippe Morel ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Reference Values ◽  
Total Protein ◽  
Age Groups ◽  
Term Neonates ◽  
Age Related ◽  
The Central Nervous System ◽  
Set Up ◽  
Age Range ◽  
Cerebrospinal Fluid Protein

Abstract Background: The published reference values for cerebrospinal fluid (CSF) total protein concentrations in children suffer from two major drawbacks: (a) the age-related range often is too broad when applied to the steeply falling concentrations in early infancy; and (b) no values have been published for widely used dry chemistry methods. Methods: We conducted a 2-year retrospective survey of CSF results obtained in a children’s hospital with a dry chemistry-based method set up on the Vitros 700 analyzer. Results: The data related to ambulatory children up to 16 years of age and term neonates with no clinical or biological signs of brain disease (n = 1074). Seven age groups with significantly different CSF protein values were identified, and their age-related percentiles (5th, 50th, and 95th) were determined. On the basis of the upper 95th percentile, from age 0 to 6 months the CSF protein concentrations fell rapidly from 1.08 to 0.40 g/L. A plateau (0.32 g/L) was reached from age 6 months to 10 years, followed by a slight increase (0.41 g/L) in the 10–16 years age range. Conclusions: These results imply that CSF total protein concentrations in the pediatric setting, particularly in infants, must always be interpreted with regard to narrow age-related reference values to avoid false-positive results.

scholarly journals Upper Lip Horizontal Line: Characteristics of a Dynamic Facial Line

2020 ◽  
Vol 17 (18) ◽  
pp. 6672
Author(s):  
Alexander D Vardimon ◽  
Nir Shpack ◽  
Atalia Wasserstein ◽  
Marilena Skyllouriotou ◽  
Morris Strauss ◽  
...  
Keyword(s):  
Dental Treatment ◽  
Age Groups ◽  
Treatment Modalities ◽  
Horizontal Line ◽  
Facial Morphology ◽  
Upper Lip ◽  
Age Related ◽  
Cast Model ◽  
And Gender ◽  
Gummy Smile

Background: Upper lip appearance received major attention with the introduction of diverse treatment modalities, including lip augmentation, rhinoplasty surgery, and dental treatment designed to support the upper lip. Our objectives were to define the prevalence and characteristics of the upper lip horizontal line (ULHL), which is a dynamic line appearing during a smile, in relation to gender, malocclusions, aging, and facial morphology. Methods: First, the prevalence and gender distribution of ULHL was examined from standardized en-face imaging at full smile of 643 randomly selected patients. Second, cephalometric and dental cast model analyses were made for 97 consecutive patients divided into three age groups. Results: ULHL appears in 13.8% of the population examined, and prevailed significantly more in females (78%). The prevalence of ULHL was not related to age nor to malocclusion. Patients presenting ULHL showed shorter upper lip and deeper lip sulcus. The skeletal pattern showed longer mid-face, shorter lower facial height and greater prevalence of a gummy smile. Conclusions: Female patients with short upper lip, concavity of the upper lip, and gummy smile are more likely to exhibit ULHL. The ULHL is not age-related and can be identified in children and young adults. Therefore, it should be considered when selecting diverse treatment modalities involving the upper lip.

Olfactory Acuity as a Function of Age and Gender: A Comparison of African and American Samples

1997 ◽  
Vol 44 (4) ◽  
pp. 317-334 ◽  
Author(s):  
Clifton E. Barber
Keyword(s):  
Age Groups ◽  
Chemical Exposure ◽  
Sensory Impairment ◽  
Age And Gender ◽  
National Geographic ◽  
Olfactory Acuity ◽  
Age Related ◽  
International Data ◽  
And Gender ◽  
Survey Responses

A frequently reported finding in age-related sensory impairment is that olfaction shows consistent and uniform decline with age. In most studies, discerning whether loss in olfaction is due to aging per se or to factors extrinsic to the aging process (e.g., smoking, chemical exposure, head injury) is difficult. Moreover, studies of olfaction have generally relied on data collected from samples drawn primarily from Western societies. As such, little is known regarding differences in olfaction involving non-Western cultures. Using international data from the 1986 National Geographic Smell Survey, responses of 19,219 American respondents and 3,204 respondents from Africa were analyzed. All respondents were screened for factors negatively affecting olfaction. Measures of olfactory acuity included odor detection, identification, intensity, and quality. The odor of interest was androstenone, a scent produced by bacteria on the human body and appearing in sweat. The results indicate that some measures of olfactory acuity tend to decline across age groups, but that this decline is less marked than reported in previous studies. The most important finding is that loss of olfaction is not consistent or uniform between geographic regions of America or Africa, between male vs. female respondents, or among the four measures of olfactory acuity. African respondents (both men and women) had significantly higher percentages of detection than did American respondents, women generally reported higher levels of olfactory functioning than did men, and some measures of olfaction were stable across age groups, or were higher among older respondents (e.g., odor identification).

scholarly journals Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study

2020 ◽  
Author(s):  
Peng Shi ◽  
Xiaobo Zhang ◽  
Lijuan Liu ◽  
Liangfeng Tang ◽  
Jing Li ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Respiratory Infections ◽  
Age Groups ◽  
Childhood Mortality ◽  
Teaching Hospitals ◽  
Annual Growth Rate ◽  
Age And Gender ◽  
Outpatient Visits ◽  
And Gender ◽  
Gender Specific

Abstract Background: Respiratory infections are one of three leading causes of childhood mortality, and worldwide increase and recent plateau in childhood asthma has been reported. However, data on trends of respiratory diseases over long period of time is limited. This study aimed to determine the trends of respiratory disease outpatient visits (ROVs) and diagnoses (RODs) in one of the largest children’s teaching hospitals in China between 2009 and 2018. Methods: A retrospective study based on routine administrative data was designed and implemented according to the RECORD statement. Demographic details and diagnoses of the outpatients <18 years visiting the respiratory department of the hospital were extracted from the Hospital Information System. Age- and gender-specific trends were illustrated by calculating average annual growth rate (AAGR) for ROVs and comparing change of proportion for different RODs over time. Results: There were 698054 ROVs from 285574 children (40.4% female). AAGR of ROVs was 15.2%. Children aged 4 to < 7 years had a faster increase than other age groups. Bronchitis (27.6%), pneumonia (18.5%), pneumonia affecting other systems (18.4%), asthma and status asthmaticus (10.7%), and vasomotor and allergic rhinitis (9.2%) accounted for 84.4% of all RODs. The proportion of bronchitis decreased across years, with the concomitant increasing trend in the proportion of pneumonia. Age-specific trend in diagnoses showed greater proportion of asthma in all visits for the children aged 7 to < 18 years than younger children. Gender-specific trend in diagnoses showed the proportion of asthma was greater for males but the AAGR was greater for females. Conclusion: The persistent upward trend in ROVs was observed among children at different ages and a gender difference was also seen. In contrast to what has been reported, burden of asthma and allergies diseases continues to increase locally.

scholarly journals Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016

2021 ◽  
Vol 27 ◽  
Author(s):  
Lilla Tamási ◽  
Krisztián Horváth ◽  
Zoltán Kiss ◽  
Krisztina Bogos ◽  
Gyula Ostoros ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Age Groups ◽  
Age Group ◽  
Lung Cancer Incidence ◽  
Age And Gender ◽  
Female Population ◽  
Incidence And Mortality ◽  
Icd 10 ◽  
And Gender ◽  
Gender Specific

Objective: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungary based on a retrospective analysis of the National Health Insurance Fund database.Methods: This longitudinal study included patients aged ≥20 years with LC diagnosis (ICD-10 C34) between January 1, 2011 and December 31, 2016. Patients with different cancer-related codes 6 months before or 12 months after LC diagnosis or having any cancer treatment other than lung cancer protocols were excluded.Results: Lung cancer incidence and mortality increased with age, peaking in the 70–79 age group (375.0/100,000 person-years) among males, while at 60–69 age group for females (148.1/100,000 person-years). The male-to-female incidence rate ratio reached 2.46–3.01 (p &lt; 0.0001) among the 70–79 age group. We found 2–11% decrease in male incidence rate at most age groups, while a significant 1–3% increase was observed in older females (&gt;60) annually during the study period.Conclusion: This nationwide epidemiology study demonstrated that LC incidence and mortality in Hungary decreased in younger male and female population, however we found significant increase of incidence in older female population, similar to international trends. Incidence rates peaked in younger age-groups compared to Western countries, most likely due to higher smoking prevalence in these cohorts, while lower age LC incidence could be attributed to higher competing cardiovascular risk resulting in earlier mortality in smoking population.

scholarly journals BMI-Referenced Cut Points for Pedometer-Determined Steps per Day in Adults

2008 ◽  
Vol 5 (s1) ◽  
pp. S126-S139 ◽  
Author(s):  
C. Tudor-Locke ◽  
D.R. Bassett ◽  
W.J. Rutherford ◽  
B.E. Ainsworth ◽  
C.B. Chan ◽  
...  
Keyword(s):  
Weight Status ◽  
Age Groups ◽  
Normal Weight ◽  
Policy Changes ◽  
Cut Points ◽  
Younger Age ◽  
Steps Per Day ◽  
Criterion Referenced ◽  
And Gender ◽  
Gender Specific

Background:The goal of this study was to establish preliminary criterion-referenced cut points for adult pedometer-determined physical activity (PA) related to weight status defined by body mass index (BMI).Methods:Researchers contributed directly measured BMI and pedometer data that had been collected (1) using a Yamax-manufactured pedometer, (2) for a minimum of 3 days, (3) on ostensibly healthy adults. The contrasting groups method was used to identify age- and gender-specific cut points for steps/d related to BMI cut points for normal weight and overweight/obesity (defined as BMI <25 and ≥25 kg/m2, respectively).Results:Data included 3127 individuals age 18 to 94 years (976 men, age = 46.8 ± 15.4 years, BMI = 27.3 ± 4.9; 2151 women, age = 47.4 ± 14.9 years, BMI = 27.6 ± 6.4; all gender differences NS). Best estimated cut points for normal versus overweight/obesity ranged from 11,000 to 12,000 steps/d for men and 8000 to 12,000 steps/d for women (consistently higher for younger age groups).Conclusions:These steps/d cut points can be used to identify individuals at risk, or the proportion of adults achieving or falling short of set cut points can be reported and compared between populations. Cut points can also be used to set intervention goals, and they can be referred to when evaluating program impact, as well as environmental and policy changes.

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