scholarly journals Assessment of thiol/disulfide balance as an oxidative stress marker in children with β-thalassemia major

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Ahmet Guzelcicek ◽  
Gokhan Cakirca ◽  
Ozcan Erel ◽  
Abdullah Solmaz
Keyword(s):  
Oxidative Stress ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Oxidative Stress Marker ◽  
Creative Commons ◽  
Pediatric Hematology ◽  
Stress Marker ◽  
Oxidative Stress Status ◽  
Blood Specimens

Objective: We aimed to investigate the oxidative stress status in children with β-thalassemia major (β-TM) by measuring native thiol (SH), disulfide (SS) and total thiol (SH + SS) plasma levels. Methods: This study was carried out from November 2017 to March 2018 at the Pediatric Hematology Clinic of the Harran University Medical Faculty Hospital. Blood specimens were collected from 100 participants, including 50 β-TM patients and 50 controls, and SH, SS and SH+SS levels were detected through a newly developed method. Results: SH, SS, SH+SS levels and SS/SH ratio were markedly higher in β-TM patients than in controls. In β-TM group, SH and SH+SS levels were positively correlated with age, albumin and total bilirubin. Serum ferritin level was positively correlated with SH, SH+SS, aspartate transaminase and alanine transaminase. Conclusions: We found that the SS/SH ratio was high in patients with β-TM, which shows increased oxidative stress. This ratio may be considered as a tool for the determination of oxidative status in such patients due to easily calculate, suitable for routine use and economical. How to cite this:Guzelcicek A, Cakirca G, Erel O, Abdullah Solmaz4. Assessment of thiol/disulfide balance as an oxidative stress marker in children with β-thalassemia major. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.307 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Diurnal variation of salivary oxidative stress marker 8-hydroxyguanine

2019 ◽  
Vol 41 (1) ◽  
Author(s):  
Sintaroo Watanabe ◽  
Yuya Kawasaki ◽  
Kazuaki Kawai
Keyword(s):  
Oxidative Stress ◽  
Risk Factor ◽  
Diurnal Variation ◽  
Life Style ◽  
Oxidative Stress Marker ◽  
Diurnal Pattern ◽  
Average Amount ◽  
Stress Marker ◽  
Oxidative Stress Status ◽  
The Individual

Abstract Introduction Oxidative stress is a risk factor for life-style related diseases, including cancer. We recently reported that the oxidative stress marker 8-hydroxyguanine (8-OHGua) can be measured in saliva non-invasively. Understanding the diurnal pattern of salivary 8-OHGua levels is crucial for evaluating the oxidative stress. In this study, we analyzed the diurnal variation of salivary 8-OHGua levels. Findings The salivary 8-OHGua levels were relatively stable in the daytime (10:00–22:00). The daytime 8-OHGua levels seemed to represent the individual oxidative stress status. The average amount and the variation of the salivary 8-OHGua levels immediately after awakening were higher than those of the daytime levels. Conclusions The 8-OHGua levels in saliva exhibited diurnal variation. The levels were higher at the time of awakening. At this point, the daytime levels of salivary 8-OHGua may be appropriate for evaluating the individual oxidative stress status. Further study is needed for understanding and utilizing the 8-OHGua levels at the time of awakening.

Ischemia modified albumin: An oxidative stress marker in β-thalassemia major

2012 ◽  
Vol 413 (9-10) ◽  
pp. 907-910 ◽  
Author(s):  
Samir M. Awadallah ◽  
Manar F. Atoum ◽  
Nisreen A. Nimer ◽  
Suleiman A. Saleh
Keyword(s):  
Oxidative Stress ◽  
Thalassemia Major ◽  
Oxidative Stress Marker ◽  
Ischemia Modified Albumin ◽  
Stress Marker

Trace elements as an oxidative stress marker in women with gestational diabetes and their neonates

2017 ◽  
Author(s):  
Georgios Boutzios ◽  
Eleni Koukoulioti ◽  
Ioannis Papoutsis ◽  
Sotirios Athanaselis ◽  
Gerasimos Tsourouflis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Gestational Diabetes ◽  
Oxidative Stress Marker ◽  
Stress Marker

Oxidative Stress Status in Patients with Choledocholithiasis: Before and After Endoscopic Sphincterotomy and Biliary Clearance

2018 ◽  
Vol 69 (8) ◽  
pp. 2172-2176
Author(s):  
Catalin Victor Sfarti ◽  
Alin Ciobica ◽  
Carol Stanciu ◽  
Gheorghe G. Balan ◽  
Irina Garleanu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoscopic Sphincterotomy ◽  
Specific Activity ◽  
Oxidative Stress Marker ◽  
Control Group ◽  
Oxidative Stress Parameter ◽  
Extrahepatic Cholestasis ◽  
Biliary Clearance ◽  
Oxidative Stress Status ◽  
Before And After

Choledocholithiasis may cause biliary obstruction which leads to hepatocellular injury. Oxidative stress has been proposed as a possible mechanism involved in this disorder. This study evaluates the oxidative stress burden in patients with choledocholithiasis and secondary cholestasis, before and after endoscopic sphincterotomy. Experimental part: Patients diagnosed with choledocholithiasis and secondary extrahepatic cholestasis were included in the study between January 1st 2016 and October 31st 2016. In all patients oxidative stress markers were collected within 2 hours before and 48 hours after therapeutic ERCP. Selected markers were superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA). The results were compared to those from a group of 40 healthy subjects. Significantly lower concentrations of SOD (p = 0.03) and GPX (p [ 0.0001) activities, associated with an increased level of MDA level (p [ 0.0001) were shown in patients before biliary clearance compared with the healthy control group. After ERCP the only oxidative stress parameter which showed improvement was the SOD specific activity (p = 0.037). This study shows that extrahepatic cholestasis secondary to choledocholithiasis is associated with increased oxidative stress status. After biliary clearance one oxidative stress marker was significantly improved (SOD), suggesting a possible antioxidant effect of such procedure.

The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients

2011 ◽  
Vol 15 (3) ◽  
pp. 398-404 ◽  
Author(s):  
Yoshiyuki Morishita ◽  
Shiho Hanawa ◽  
Takuya Miki ◽  
Taro Sugase ◽  
Yasuhiro Sugaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hemodialysis Patients ◽  
Oxidative Stress Marker ◽  
Stress Marker
Sign in / Sign up

Export Citation Format

Share Document