The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major

Author(s):  
2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Ahmet Guzelcicek ◽  
Gokhan Cakirca ◽  
Ozcan Erel ◽  
Abdullah Solmaz

Objective: We aimed to investigate the oxidative stress status in children with β-thalassemia major (β-TM) by measuring native thiol (SH), disulfide (SS) and total thiol (SH + SS) plasma levels. Methods: This study was carried out from November 2017 to March 2018 at the Pediatric Hematology Clinic of the Harran University Medical Faculty Hospital. Blood specimens were collected from 100 participants, including 50 β-TM patients and 50 controls, and SH, SS and SH+SS levels were detected through a newly developed method. Results: SH, SS, SH+SS levels and SS/SH ratio were markedly higher in β-TM patients than in controls. In β-TM group, SH and SH+SS levels were positively correlated with age, albumin and total bilirubin. Serum ferritin level was positively correlated with SH, SH+SS, aspartate transaminase and alanine transaminase. Conclusions: We found that the SS/SH ratio was high in patients with β-TM, which shows increased oxidative stress. This ratio may be considered as a tool for the determination of oxidative status in such patients due to easily calculate, suitable for routine use and economical. How to cite this:Guzelcicek A, Cakirca G, Erel O, Abdullah Solmaz4. Assessment of thiol/disulfide balance as an oxidative stress marker in children with β-thalassemia major. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.307 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2017 ◽  
Vol 124 (12) ◽  
pp. 1557-1566 ◽  
Author(s):  
Mariacristina Siotto ◽  
Irene Aprile ◽  
Ilaria Simonelli ◽  
Costanza Pazzaglia ◽  
Mariacarla Ventriglia ◽  
...  

1980 ◽  
Vol 14 (12) ◽  
pp. 1425-1425
Author(s):  
F Morle ◽  
J Delaunay ◽  
L Morle ◽  
R Bouhass ◽  
M Aguercif ◽  
...  

2016 ◽  
Vol 4 (10) ◽  
pp. 2132-2140
Author(s):  
IsraaA.AbdulKareem MBChB,MS.c,FICMS ◽  
◽  
EnasAdnanAAl-Kazaaly MBChB,CABOG,FIBMS ◽  
MohammedI.Hamzah Ph.D ◽  
◽  
...  

2006 ◽  
Vol 61 (3) ◽  
pp. 357-365
Author(s):  
Yuki MATSUMOTO ◽  
Yasutaka OGAWA ◽  
Rie YOSHIDA ◽  
Akinori NAKATA ◽  
Hiroshi KASAI ◽  
...  

2012 ◽  
Vol 38 (3) ◽  
pp. 487-491 ◽  
Author(s):  
Hoda Nassar ◽  
Shigetaka Furukado ◽  
Makiko Tanaka ◽  
Kaori Miwa ◽  
Shuhei Okazaki ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document