Human resources are the main competitive advantage of the company in a market economy. The variety of forms of institutions and organizations becomes a factor of structuring and development of the regional economy. Special attention of scientists and practitioners in the fields of not only Economics, but also politics, law, sociology, psychology attracts collaboration as a poorly studied, but rapidly developing and effective form of relations between economic entities in order to increase competitiveness. The purpose of the article: to determine the features of collaborative interaction of the University in the management of human resources in the regional labor market. On the basis of the analysis of works of domestic and foreign scientists the essence and content of collaboration as process of joint labor, production or economic activity of two and more economic subjects for achievement of the General purposes is defined. It is revealed that the collaborative interaction is based on the principles of consent and trust, i.e. there is a mutually beneficial exchange of knowledge, training of participants to improve their competencies, the production of innovative products with a significant intellectual component to promote to the market and achieve effects in the development of competitiveness of the regional economy. In the course of the pilot study, the cycle and a number of features of the formation of students ‘ competitiveness as a human resource of the regional market are highlighted. In this article, the collaboration is considered from the position of technology to increase the competitiveness of human resources. As a result, the features and effects of collaboration between the University and representatives of the regional market of Krasnoyarsk region are highlighted. The author’s position in the definition of collaboration for companies and the University from the position of the strategy of coordination of interests in the regional labor market is based on the results of a pilot study and has practical significance in the development of the efficiency of human resources management in the region.