scholarly journals Oxidative damage to DNA: Inhibition of guanine damage

2006 ◽  
Vol 78 (12) ◽  
pp. 2297-2304 ◽  
Author(s):  
Sriram Kanvah ◽  
Gary B. Schuster
Keyword(s):  
Oxidative Damage ◽  
Structural Changes ◽  
Global Structure ◽  
Chemical Damage ◽  
Oxidation Of Dna ◽  
Anthraquinone Derivatives ◽  
Covalently Linked ◽  
The One ◽  
Oxidative Damage To Dna ◽  
Dna Inhibition

One-electron oxidation of DNA results in chemical damage to nucleobases, particularly guanine in multiple G sequences. Oxidation may be triggered by numerous events, including photosensitization. We describe studies of photoinduced oxidations of DNA triggered by irradiation of covalently linked anthraquinone derivatives under various conditions that affect the global structure of the DNA. These structural changes have subtle effects on the result of the one-electron oxidation.

scholarly journals Entangling Lattice-Trapped Bosons with a Free Impurity: Impact on Stationary and Dynamical Properties

Entropy ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 290
Author(s):  
Maxim Pyzh ◽  
Kevin Keiler ◽  
Simeon I. Mistakidis ◽  
Peter Schmelcher
Keyword(s):  
Structural Changes ◽  
Many Body ◽  
Wide Range ◽  
Entropy Measures ◽  
Particle Level ◽  
The Many ◽  
The One ◽  
Tunneling Dynamics ◽  
The Individual ◽  
Trapped Bosons

We address the interplay of few lattice trapped bosons interacting with an impurity atom in a box potential. For the ground state, a classification is performed based on the fidelity allowing to quantify the susceptibility of the composite system to structural changes due to the intercomponent coupling. We analyze the overall response at the many-body level and contrast it to the single-particle level. By inspecting different entropy measures we capture the degree of entanglement and intraspecies correlations for a wide range of intra- and intercomponent interactions and lattice depths. We also spatially resolve the imprint of the entanglement on the one- and two-body density distributions showcasing that it accelerates the phase separation process or acts against spatial localization for repulsive and attractive intercomponent interactions, respectively. The many-body effects on the tunneling dynamics of the individual components, resulting from their counterflow, are also discussed. The tunneling period of the impurity is very sensitive to the value of the impurity-medium coupling due to its effective dressing by the few-body medium. Our work provides implications for engineering localized structures in correlated impurity settings using species selective optical potentials.

scholarly journals The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Nenad Stojiljkovic ◽  
Sonja Ilic ◽  
Vladimir Jakovljevic ◽  
Nikola Stojanovic ◽  
Slavica Stojnev ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Structural Changes ◽  
Corn Oil ◽  
Kidney Tissue ◽  
Kidney Injury ◽  
Serum Urea ◽  
Morphological Alterations ◽  
Injury Model ◽  
Serum Biochemical ◽  
Degree Of Recovery

Methotrexate is an antimetabolic drug with a myriad of serious side effects including nephrotoxicity, which presumably occurs due to oxidative tissue damage. Here, we evaluated the potential protective effect of lycopene, a potent antioxidant carotenoid, given in two different pharmaceutical forms in methotrexate-induced kidney damage in rats. Serum biochemical (urea and creatinine) and tissue oxidative damage markers and histopathological kidney changes were evaluated after systemic administration of both lycopene dissolved in corn oil and lycopene encapsulated in nanoliposomes. Similar to previous studies, single dose of methotrexate induced severe functional and morphological alterations of kidneys with cell desquamation, tubular vacuolation, and focal necrosis, which were followed by serum urea and creatinine increase and disturbances of tissue antioxidant status. Application of both forms of lycopene concomitantly with methotrexate ameliorated changes in serum urea and creatinine and oxidative damage markers and markedly reversed structural changes of kidney tissue. Moreover, animals that received lycopene in nanoliposome-encapsulated form showed higher degree of recovery than those treated with free lycopene form. The findings of this study indicate that treatment with nanoliposome-encapsulated lycopene comparing to lycopene in standard vehicle has an advantage as it more efficiently reduces methotrexate-induced kidney dysfunction.

scholarly journals Oxidative damage to DNA: do we have a reliable biomarker?

1996 ◽  
Vol 104 (suppl 3) ◽  
pp. 465-469 ◽  
Author(s):  
A R Collins ◽  
M Dusinská ◽  
C M Gedik ◽  
R Stĕtina
Keyword(s):  
Oxidative Damage ◽  
Oxidative Damage To Dna

scholarly journals Structural changes and economic growth in the world economy and Russia

2019 ◽  
Vol 5 (1) ◽  
pp. 1-26 ◽  
Author(s):  
Valeriy V. Mironov ◽  
Liudmila D. Konovalova
Keyword(s):  
Economic Growth ◽  
Growth Rate ◽  
Global Economy ◽  
World Economy ◽  
Structural Changes ◽  
Russian Economy ◽  
The World ◽  
Preliminary Version ◽  
The One ◽  
Relationship Of

The article considers the problem of the relationship of structural changes and economic growth in the global economy and Russia in the framework of different methodological approaches. At the same time, the paper provides the analysis of complementarity of economic policy types, which, on the one hand, are aimed at developing the fundamentals of GDP growth (institutions, human capital and macroeconomic stabilization), and on the other hand, at initiating growth (with stable fundamentals) with the help of structural policy measures. In the study of structural changes in the global economy, new forms of policies of this kind have been revealed, in particular aimed at identifying sectors — drivers of economic growth based on a portfolio approach. In a given paper a preliminary version of the model of the Russian economy is provided, using a multisector version of the Thirlwall’s Law. Besides, the authors highlight a number of target parameters of indicators of competitiveness of the sectors of the Russian economy that allow us to expect its growth rate to accelerate above the exogenously given growth rate of the world economy.

scholarly journals Monitoring the degradation of partly decomposable plastic foils

2014 ◽  
Vol 6 (1) ◽  
pp. 39-44
Author(s):  
Gabriella Rétháti ◽  
Krisztina Pogácsás ◽  
Tamás Heffner ◽  
Barbara Simon ◽  
Imre Czinkota ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Molecular Mass ◽  
Structural Changes ◽  
Thermoplastic Starch ◽  
Medium Density ◽  
Insulating Layer ◽  
Elongation At Break ◽  
One Year ◽  
The One

Abstract We have monitored the behaviour of different polyethylene foils including virgin medium density polyethylene (MDPE), MDPE containing pro-oxydative additives (238, 242) and MDPE with pro-oxydative additives and thermoplastic starch (297) in the soil for a period of one year. A foil based on a blend of polyester and polylactic acid (BASF Ecovio) served as degradable control. The experiment was carried out by weekly measurements of conductivity and capacity of the soil, since the setup was analogous to a condenser, of which the insulating layer was the foil itself. The twelve replications allowed monthly sampling; the specimen taken out from the soil each month were tested visually for thickness, mechanical properties, morphological and structural changes, and molecular mass. Based on the obtained capacity values, we found that among the polyethylene foils, the one that contained thermoplastic starch extenuated the most. This foil had the greatest decrease in tensile strength and elongation at break due to the presence of thermoplastic starch. The starch can completely degrade in the soil; thus, the foil had cracks and pores. The polyethylene foils that contained pro-oxydant additives showed smaller external change compared to the virgin foil, since there was no available UV radiation and oxygen for their degradation. The smallest change occurred in the virgin polyethylene foil. Among the five examined samples, the commercially available BASF foil showed the largest extenuation and external change, and it deteriorated the most in the soil.

scholarly journals Optimization of Trade Structure Between Russia and China Under the Initiative «One Belt and One Way»

2019 ◽  
Vol 3 (3) ◽  
pp. 17-24
Author(s):  
Bo Lyu
Keyword(s):  
Development Strategy ◽  
Structural Changes ◽  
Political Climate ◽  
National Interests ◽  
Trade Relations ◽  
Bilateral Relations ◽  
Strategic Trade ◽  
The World ◽  
Chinese Trade ◽  
The One

Russia is a very important partner in the Chinese development strategy «One Belt and One Way». Deepening of Russian-Chinese trade and economic cooperation meets the national interests and aspirations of Russia and China, playing a catalytic role in the development of bilateral relations and stabilizing the political and economic situation on the Eurasian continent and in the world. The development of Russian-Chinese trade relations have undergone many cooperative processes, and trade itself overtime has revealed its own pecularities, related to the time and political climate. Russia and China are the two largest economic powers in the world, and they have significant prospects and potential for cooperation. After China put forward the «One Belt and One Way» strategic development plan, the prospect of cooperation between the two countries has attracted an increasing attention. The article analyzes the history and current state of bileteral strategic trade relations. Some research opinions are put forward considering structural changes in the development process.

scholarly journals Mixed Ca/Sr salt forms of salicylic acid: tuning structure and aqueous solubility

2018 ◽  
Vol 74 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Pamela Allan ◽  
Jean-Baptiste Arlin ◽  
Alan R. Kennedy ◽  
Aiden Walls
Keyword(s):  
Salicylic Acid ◽  
Coordination Polymer ◽  
Single Crystal ◽  
Structural Feature ◽  
Structural Changes ◽  
Aqueous Solubility ◽  
Single Crystal Diffraction ◽  
One Dimensional ◽  
The One ◽  
Salt Forms

Ten isostructural single-crystal diffraction studies of mixed cation Ca/Sr salt forms of the salicylate anion are presented, namely catena-poly[[diaquacalcium(II)/strontium(II)]-bis(μ2-2-hydroxybenzoato)], [Ca1–x Sr x (C7H5O3)2(H2O)2] n , where x = 0, 0.041, 0.083, 0.165, 0.306, 0.529, 0.632, 0.789, 0.835 and 1. The structure of an isostructural Sr/Ba species, namely catena-poly[[diaquastrontium(II)/barium(II)]-bis(μ2-2-hydroxybenzoato)], [Sr0.729Ba0.271(C7H5O3)2(H2O)2], is also described. The Ca/Sr structures form a series where, with increasing Sr content, the unit cell expands in both the crystallographic a and c directions (by 1.80 and 3.18%, respectively), but contracts slightly in the b direction (−0.31%). The largest percentage structural expansion lies parallel to the direction of propagation of the one-dimensional coordination polymer that is the primary structural feature. This structural expansion is thus associated with increased M—O distances. Aqueous solubility measurements show that solubility generally increases with increasing Sr content. Thus, tuning the composition of these mixed counter-ion salt forms leads to systematic structural changes and allows solubility to be tuned to values between those for the pure Ca and Sr species.

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