scholarly journals BMP9 Protects Septal Neurons from Axotomy-Evoked Loss of Cholinergic Phenotype

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e21166 ◽  
Author(s):  
Ignacio Lopez-Coviella ◽  
Tiffany J. Mellott ◽  
Aletta C. Schnitzler ◽  
Jan K. Blusztajn
Keyword(s):  
Cholinergic Phenotype ◽  
Septal Neurons

Neurotrophin-4/5 Maintains the Cholinergic Phenotype of Axotomized Septal Neurons

1996 ◽  
Vol 8 (2) ◽  
pp. 282-290 ◽  
Author(s):  
Ralph F. Alderson ◽  
Stanley J. Wiegand ◽  
Keith D. Anderson ◽  
Ning Cai ◽  
Jae-Young Cho ◽  
...  
Keyword(s):  
Cholinergic Phenotype ◽  
Septal Neurons

scholarly journals Sodium and calcium currents in dispersed mammalian septal neurons.

1991 ◽  
Vol 97 (2) ◽  
pp. 303-320 ◽  
Author(s):  
A Castellano ◽  
J López-Barneo
Keyword(s):  
Time Constant ◽  
Time Course ◽  
Calcium Currents ◽  
Closing Time ◽  
Patch Clamp Technique ◽  
Average Value ◽  
Time To Peak ◽  
Time Courses ◽  
Fast Activation ◽  
Septal Neurons

Voltage-gated Na+ and Ca2+ conductances of freshly dissociated septal neurons were studied in the whole-cell configuration of the patch-clamp technique. All cells exhibited a large Na+ current with characteristic fast activation and inactivation time courses. Half-time to peak current at -20 mV was 0.44 +/- 0.18 ms and maximal activation of Na+ conductance occurred at 0 mV or more positive membrane potentials. The average value was 91 +/- 32 nS (approximately 11 mS cm-2). At all membrane voltages inactivation was well fitted by a single exponential that had a time constant of 0.44 +/- 0.09 ms at 0 mV. Recovery from inactivation was complete in approximately 900 ms at -80 mV but in only 50 ms at -120 mV. The decay of Na+ tail currents had a single time constant that at -80 mV was faster than 100 microseconds. Depolarization of septal neurons also elicited a Ca2+ current that peaked in approximately 6-8 ms. Maximal peak Ca2+ current was obtained at 20 mV, and with 10 mM external Ca2+ the amplitude was 0.35 +/- 0.22 nA. During a maintained depolarization this current partially inactivated in the course of 200-300 ms. The Ca2+ current was due to the activity of two types of conductances with different deactivation kinetics. At -80 mV the closing time constants of slow (SD) and fast (FD) deactivating channels were, respectively, 1.99 +/- 0.2 and 0.11 +/- 0.03 ms (25 degrees C). The two kinds of channels also differed in their activation voltage, inactivation time course, slope of the conductance-voltage curve, and resistance to intracellular dialysis. The proportion of SD and FD channels varied from cell to cell, which may explain the differential electrophysiological responses of intracellularly recorded septal neurons.

Effects of tianeptine and other antidepressants on the activity of medial septal neurons in rats anesthetized with urethane

1991 ◽  
Vol 1 (3) ◽  
pp. 402-403
Author(s):  
M.H Bassant ◽  
B.H Lee ◽  
F Jazat ◽  
Y Lamour ◽  
E Mocaer
Keyword(s):  
Septal Neurons

Comparison of activities between medial and lateral septal neurons in rats during performance of spatial tasks

1998 ◽  
Vol 31 ◽  
pp. S231 ◽  
Author(s):  
Ryoi Tamura ◽  
Tian Lu Zhou ◽  
Satoshi Eifuku ◽  
Taketoshi Ono
Keyword(s):  
Spatial Tasks ◽  
Septal Neurons

Growth factor effects on survival and development of calbindin immunopositive cultured septal neurons

2000 ◽  
Vol 51 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Alberto Silva ◽  
Jeremy R Montague ◽  
Tomas F Lopez ◽  
Laura M Mudd
Keyword(s):  
Growth Factor ◽  
Survival And Development ◽  
Septal Neurons
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