scholarly journals Cell Type-Specific Subcellular Localization of Phospho-TBK1 in Response to Cytoplasmic Viral DNA

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83639 ◽  
Author(s):  
Takayuki Suzuki ◽  
Hiroyuki Oshiumi ◽  
Moeko Miyashita ◽  
Hussein Hassan Aly ◽  
Misako Matsumoto ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Cell Type ◽  
Viral Dna ◽  
Cell Type Specific

scholarly journals Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

2012 ◽  
Vol 23 (15) ◽  
pp. 2955-2962 ◽  
Author(s):  
Dave Bridges ◽  
Jing-Tyan Ma ◽  
Sujin Park ◽  
Ken Inoki ◽  
Lois S. Weisman ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Subcellular Localization ◽  
Target Of Rapamycin ◽  
Class Iii ◽  
Cell Type ◽  
Phosphatidylinositol 3 Kinase ◽  
Mechanistic Target Of Rapamycin ◽  
Cell Type Specific ◽  
Stepwise Formation ◽  
Phosphatidylinositol 3

The kinase complex mechanistic target of rapamycin 1 (mTORC1) plays an important role in controlling growth and metabolism. We report here that the stepwise formation of phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) regulates the cell type–specific activation and localization of mTORC1. PI(3)P formation depends on the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2α, as well as the class III PI3K Vps34, while PI(3,5)P2 requires the phosphatidylinositol-3-phosphate-5-kinase PIKFYVE. In this paper, we show that PIKFYVE and PI3K-C2α are necessary for activation of mTORC1 and its translocation to the plasma membrane in 3T3-L1 adipocytes. Furthermore, the mTORC1 component Raptor directly interacts with PI(3,5)P2. Together these results suggest that PI(3,5)P2 is an essential mTORC1 regulator that defines the localization of the complex.

scholarly journals Subcellular Localization of Axl1, the Cell Type-Specific Regulator of Polarity

2002 ◽  
Vol 12 (15) ◽  
pp. 1347-1352 ◽  
Author(s):  
Matthew Lord ◽  
Fumika Inose ◽  
Takatoshi Hiroko ◽  
Toshihiro Hata ◽  
Atsushi Fujita ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Cell Type ◽  
Cell Type Specific

The subcellular localization of OTX2 is cell-type specific and developmentally regulated in the mouse retina

2000 ◽  
Vol 78 (1-2) ◽  
pp. 26-37 ◽  
Author(s):  
D Baas ◽  
K.M Bumsted ◽  
J.A Martinez ◽  
F.M Vaccarino ◽  
K.C Wikler ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Mouse Retina ◽  
Cell Type ◽  
Developmentally Regulated ◽  
Cell Type Specific

scholarly journals Glial cell type-specific subcellular localization of 14-3-3 zeta: An implication for JCV tropism

Glia ◽  
2009 ◽  
Vol 57 (9) ◽  
pp. 971-977 ◽  
Author(s):  
Shivani Lamba ◽  
Veerasamy Ravichandran ◽  
Eugene O. Major
Keyword(s):  
Subcellular Localization ◽  
Glial Cell ◽  
Cell Type ◽  
Cell Type Specific

scholarly journals A Novel BAT3 Sequence Generated by Alternative RNA Splicing of Exon 11B Displays Cell Type-Specific Expression and Impacts on Subcellular Localization

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35972 ◽  
Author(s):  
Nadine Kämper ◽  
Jörg Kessler ◽  
Sebastian Temme ◽  
Claudia Wegscheid ◽  
Johannes Winkler ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Rna Splicing ◽  
Cell Type ◽  
Specific Expression ◽  
Cell Type Specific Expression ◽  
Cell Type Specific

IFIH1-deficiency results in a cell-type specific alteration of autophagic activity in response to S. typhimurium

2017 ◽  
Vol 55 (05) ◽  
pp. e28-e56
Author(s):  
S Macheiner ◽  
R Gerner ◽  
A Pfister ◽  
A Moschen ◽  
H Tilg
Keyword(s):  
Cell Type ◽  
A Cell ◽  
Cell Type Specific ◽  
Autophagic Activity ◽  
Specific Alteration
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