scholarly journals Quantitative Evaluation of Diffusion and Dynamic Contrast-Enhanced MR in Tumor Parenchyma and Peritumoral Area for Distinction of Brain Tumors

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0138573 ◽  
Author(s):  
Jing Zhao ◽  
Zhi-yun Yang ◽  
Bo-ning Luo ◽  
Jian-yong Yang ◽  
Jian-ping Chu
Keyword(s):  
Brain Tumors ◽  
Quantitative Evaluation ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Tumor Parenchyma

scholarly journals Dynamic Contrast Enhanced MRI in Glioma Diagnosis

2017 ◽  
pp. 88-96
Author(s):  
E. A. Nechipay ◽  
M. B. Dolgushin ◽  
A. I. Pronin ◽  
E. A. Kobyakova ◽  
L. M. Fadeeva
Keyword(s):  
Differential Diagnosis ◽  
Brain Tumors ◽  
Surgical Removal ◽  
Low Grade ◽  
Glial Tumors ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Informative Parameters ◽  
Contrast Enhanced ◽  
Grade Iii

The aim: to examine the possibility of using dynamic contrast  enhanced magnetic resonance imaging (DCE MRI) in clarifying the  diagnosis of glial brain tumors and the differentiation between them  on the basis of the malignancy degree. In this regard, the authors  evaluated the effectiveness of perfusion parameters (Ktrans, Kep, Ve and iAUC).Materials and methods.The study included examination of 54  patients with an established presence of brain glial tumors. Glioma  Grade I–II diagnosed in 13 (24.1%) and glioma Grade III–IV in 41  (75.9%) cases. Morphological verification of the diagnosis obtained  as a result of either surgical removal of the tumor or stereotactic biopsy was achieved in 31 (57.4%) patients: glial tumors Grade I–II  identified in 6 (19.4%), and glioma Grade III–IV – 25 (80.6%) cases. Results. According to DCE increasing of the malignancy degree of  glial tumors is followed by increasing of all perfusion parameters:  thus, the lowest values of Ktrans, Kep, Ve and iAUC were identified  in low grade gliomas (0.026 min−1, 0.845 min−1, 0.024 and 1.757,  respectively), the highest in gliomas Grade III–IV (0.052 min−1  1.083 min−1, 0.06 and 2.694, respectively). The most informative parameters with sensi tivity 90% and specificity 100% in the  differential diagnosis of gliomas Grade I-II and Grade III-IV are  Ktrans (cut-off = 0.16 min−1) and Ve (cut-off = 0.13).Conclusion.DCE MRI can be used in differential diagnosis of glial brain tumors of different malignancy grade.

Numerical Study of Transport of Anticancer Drugs in Heterogeneous Vasculature of Human Brain Tumors Using Dynamic Contrast Enhanced-Magnetic Resonance Imaging

2018 ◽  
Vol 140 (5) ◽  
Author(s):  
Ajay Bhandari ◽  
Ankit Bansal ◽  
Anup Singh ◽  
Niraj Sinha
Keyword(s):  
Magnetic Resonance Imaging ◽  
Experimental Data ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Human Brain ◽  
Therapeutic Efficacy ◽  
Free Drug ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Systemic administration of drugs in tumors is a challenging task due to unorganized microvasculature and nonuniform extravasation. There is an imperative need to understand the transport behavior of drugs when administered intravenously. In this study, a transport model is developed to understand the therapeutic efficacy of a free drug and liposome-encapsulated drugs (LED), in heterogeneous vasculature of human brain tumors. Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) data is employed to model the heterogeneity in tumor vasculature that is directly mapped onto the computational fluid dynamics (CFD) model. Results indicate that heterogeneous vasculature leads to preferential accumulation of drugs at the tumor position. Higher drug accumulation was found at location of higher interstitial volume, thereby facilitating more tumor cell killing at those areas. Liposome-released drug (LRD) remains inside the tumor for longer time as compared to free drug, which together with higher concentration enhances therapeutic efficacy. The interstitial as well as intracellular concentration of LRD is found to be 2–20 fold higher as compared to free drug, which are in line with experimental data reported in literature. Close agreement between the predicted and experimental data demonstrates the potential of the developed model in modeling the transport of LED and free drugs in heterogeneous vasculature of human tumors.

scholarly journals Measurement of Blood-Brain Barrier Permeability with T1-Weighted Dynamic Contrast-Enhanced MRI in Brain Tumors: A Comparative Study with Two Different Algorithms

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Maurizio Bergamino ◽  
Laura Saitta ◽  
Laura Barletta ◽  
Laura Bonzano ◽  
Giovanni Luigi Mancardi ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Dynamic Contrast Enhanced ◽  
Blood Brain ◽  
Contrast Enhanced ◽  
Significant Difference ◽  
Brain Barrier Permeability

The purpose of this study was to assess the feasibility of measuring different permeability parameters with T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in order to investigate the blood brain-barrier permeability associated with different brain tumors. The Patlak algorithm and the extended Tofts-Kety model were used to this aim. Twenty-five adult patients with tumors of different histological grades were enrolled in this study. MRI examinations were performed at 1.5 T. Multiflip angle, fast low-angle shot, and axial 3D T1-weighted images were acquired to calculate T1 maps, followed by a DCE acquisition. A region of interest was placed within the tumor of each patient to calculate the mean value of different permeability parameters. Differences in permeability measurements were found between different tumor grades, with higher histological grades characterized by higher permeability values. A significant difference in transfer constant (Ktrans) values was found between the two methods on high-grade tumors; however, both techniques revealed a significant correlation between the histological grade of tumors and their Ktrans values. Our results suggest that DCE acquisition is feasible in patients with brain tumors and that Ktrans maps can be easily obtained by these two algorithms, even if the theoretical model adopted could affect the final results.

Early Quantitative Evaluation of a Tumor Vasculature Disruptive Agent AVE8062 Using Dynamic Contrast-Enhanced Ultrasonography

2008 ◽  
Vol 43 (2) ◽  
pp. 100-111 ◽  
Author(s):  
Sonia Lavisse ◽  
Pascale Lejeune ◽  
Valérie Rouffiac ◽  
Nicolas Elie ◽  
Estelle Bribes ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Tumor Vasculature ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography
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