scholarly journals Albumin and the fibrinogen-to-albumin ratio: Biomarkers for the acute phase response following total knee arthroplasty

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247070
Author(s):  
Emilie Amaro ◽  
Stephanie N. Moore-Lotridge ◽  
Bronson Wessinger ◽  
Michael A. Benvenuti ◽  
Thomas J. An ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Acute Phase ◽  
Knee Arthroplasty ◽  
Acute Phase Response ◽  
Medical Center ◽  
Low Cost ◽  
Phase Response ◽  
Acute Phase Reactants ◽  
Albumin Ratio ◽  
Total Knee

Purpose Complications following total knee arthroplasty (TKA) lead to patient morbidity and cost. While acute phase reactants, such as c-reactive protein (CRP) and fibrinogen, have been used to predict complications following TKA, the extent and duration of changes in albumin levels following TKA are unknown. It is hypothesized that like CRP and fibrinogen, albumin, and the fibrinogen/albumin ratio (FAR) represent useful measures of the acute phase response (APR) following TKA. The purpose of this study was to describe the longitudinal course of albumin and FAR in healthy patients following TKA, relative to established biomarkers, and examine if the variance in albumin or FAR correlates with patient comorbidities. Methods This retrospective cohort study of patients undergoing TKA at a tertiary medical center. CRP, fibrinogen, and albumin values were collected pre- and post-operatively. An age-adjusted Charlson comorbidity index (CCI) was utilized as a measure of patient comorbidity status. Results The median preoperative albumin value was 4.3 g/dL, which dropped to 3.6 g/dL on postoperative day 1 following TKA. The albumin value returned to 93% of the baseline by postoperative week 2. The course of albumin inversely mirrored the course of CRP (r = -0.41). Median preoperative FAR was 0.087 g/L, which rose to 0.130 g/L by postoperative week 2 and returned to baseline by postoperative week 6. While preoperative FAR strongly correlated with postoperative week 2 values (r = 0.74), there was a weak positive correlation between age-adjusted CCI and pre-operative FAR (r = 0.24) in patients undergoing primary TKA. Conclusion Albumin levels follow a predictable postoperative decline that inversely correlates with CRP in healthy patients following TKA. Given the low cost and abundance of laboratories offering albumin levels, direct albumin levels and/or albumin ratios such as FAR may be underutilized biomarkers for monitoring the APR following TKA.

Do Corticosteroids Attenuate the Peri-Operative Acute Phase Response After Total Knee Arthroplasty?

2019 ◽  
Vol 34 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Adam C. Brekke ◽  
Emilie J. Amaro ◽  
Samuel L. Posey ◽  
Stephen M. Engstrom ◽  
Gregory G. Polkowski ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Acute Phase ◽  
Knee Arthroplasty ◽  
Acute Phase Response ◽  
Phase Response ◽  
Total Knee

Cost of Aseptic Revision Total Knee Arthroplasty at a Tertiary Medical Center

2020 ◽  
Author(s):  
John R. Steele ◽  
Sean P. Ryan ◽  
William A. Jiranek ◽  
Samuel S. Wellman ◽  
Michael P. Bolognesi ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Medical Center ◽  
Revision Total Knee Arthroplasty ◽  
Aseptic Revision ◽  
Total Knee

Knee Prostheses Reverse Engineering: A Preliminary Investigation

2020 ◽  
Author(s):  
Marco Rossoni ◽  
Daniele Regazzoni ◽  
Andrea Vitali ◽  
Giorgio Colombo ◽  
Luca Spandre ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Reverse Engineering ◽  
Knee Arthroplasty ◽  
Mechanical Performance ◽  
Low Cost ◽  
Preliminary Investigation ◽  
Orthopedic Procedures ◽  
Computer Assisted ◽  
Knee Prostheses ◽  
Total Knee

Abstract Total Knee Arthroplasty is one of the most commonly performed orthopedic procedures and it is expected to grow in the next future. In the last past years, computer-assisted procedures represent one of the trends that are transforming the way of practicing medicine. Cornering the Total Knee Arthroplasty, digital models of the joints have been used to carry out simulation of their kinematics and mechanical performance. Whilst for the 3D digital reconstruction of the patient geometry several studies have been conducted, an approximated geometry of the prosthesis has been several times employed, with undeniable consequences on the final results. This paper aims at comparing two non-contact reverse engineering technologies to acquire the shape of femoral components employed for total knee arthroplasty. A high-level device (Konika Minolta Vivid 9i) and a mid-low cost laser (NextEngine) has been compared. For the comparison, a systematic procedure of acquisition and elaboration of the results has been adopted in order to have as unbiased as possible results. The procedure involves the use of the proprietary software of the scanners for the elaboration of the raw data and the meshing procedure has been kept the same for all the models. Since the as-is acquired mesh is of high-resolution, a decimation procedure has been carried out in order to make the 3D models lighter and easier to be handled. Once the decimation procedure has been evaluated comparing the original and the simplified models to one another, the digitalized models have been compared with the measurements taken from a coordinate measuring machines. As a preliminary result, the two lasers seem to be adequate to accomplish the reverse engineering process as required by this application. Of course, the mid-low cost laser would be preferable whether the performance will be confirmed to be (statistically) equal.

scholarly journals Oncostatin M pathway plays a major role in the renal acute phase response

2009 ◽  
Vol 296 (4) ◽  
pp. F875-F883 ◽  
Author(s):  
Valerie A. Luyckx ◽  
Lucas V. Cairo ◽  
Catharine A. Compston ◽  
Wai Lee Phan ◽  
Thomas F. Mueller
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Deceased Donor ◽  
Phase Response ◽  
Oncostatin M ◽  
Acute Phase Reactants ◽  
Altered Expression ◽  
Severity Of Injury ◽  
Renal Tubular ◽  
Inflammatory Response To Injury

The acute phase response is traditionally characterized by hepatic synthesis of proteins as an inflammatory response to injury, with interleukin-6 (IL-6) being the key mediator. In contrast, microarray studies in human renal transplant implantation biopsies indicate a strong acute phase response in the deceased donor kidney, associated with a significant upregulation of oncostatin M receptor β (OSMR). The aim of this study was to determine whether the kidney can generate a strong acute phase response, mediated by the OSM/OSMR gateway. Genes associated with the IL-6 cytokine family and acute phase reactants were analyzed by real-time RT-PCR in four groups of human biopsies spanning a spectrum of renal injury. OSM, OSMR, and fibrinogen β (FGB) were progressively more highly expressed from prenephrectomy, living donor, deceased donor, to discarded donor kidneys, suggesting correlation with severity of injury and local renal synthesis. Acute phase response gene expression was analyzed in human proximal tubular cells in culture in response to OSM. OSM induced a significant increase in expression of FGB, OSMR, serpin peptidase inhibitor A1, IL-6, and lipopolysaccharide binding protein, and a decrease in IL-6R. These changes were largely attenuated by coincubation with an OSMR blocking antibody, indicating the OSM effect was mediated through OSMR. OSM also resulted in a significantly altered expression of acute phase genes compared with IL-6 or leukemia inhibitory factor, suggesting that OSM is the predominant cytokine mediating the renal tubular acute phase response. In conclusion, the renal parenchyma is capable of generating a strong acute phase response, likely mediated via OSM/OSMR.

The therapeutic role of motor imagery during the acute phase after total knee arthroplasty: a pilot study

2017 ◽  
Vol 41 (8) ◽  
pp. 926-933 ◽  
Author(s):  
Marcel Moukarzel ◽  
Franck Di Rienzo ◽  
Jean-Claude Lahoud ◽  
Fadi Hoyek ◽  
Christian Collet ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Pilot Study ◽  
Motor Imagery ◽  
Acute Phase ◽  
Knee Arthroplasty ◽  
Therapeutic Role ◽  
Total Knee

scholarly journals Importance of knee flexion range of motion during the acute phase after total knee arthroplasty

2020 ◽  
Vol 23 (2) ◽  
pp. 143-148
Author(s):  
Tomohiro OKA ◽  
Osamu WADA ◽  
Tsuyoshi ASAI ◽  
Hideto MARUNO ◽  
Kiyonori MIZUNO
Keyword(s):  
Total Knee Arthroplasty ◽  
Range Of Motion ◽  
Acute Phase ◽  
Knee Arthroplasty ◽  
Knee Flexion ◽  
Total Knee
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