New Medicare Technology Add-On Payment Could Be Used As A Market Support Mechanism To Accelerate Antibiotic Innovation

2021 ◽  
Vol 40 (12) ◽  
pp. 1926-1934
Author(s):  
Neil Gandhi ◽  
Kevin A. Schulman
Keyword(s):  
Support Mechanism

scholarly journals The impact of death and dying on the personhood of medical students: a systematic scoping review

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Chong Yao Ho ◽  
Cheryl Shumin Kow ◽  
Chin Howe Joshua Chia ◽  
Jia Ying Low ◽  
Yong Hao Melvin Lai ◽  
...  
Keyword(s):  
Medical Students ◽  
Scoping Review ◽  
Death And Dying ◽  
Support Mechanism ◽  
Resource Limited ◽  
Dying Patients ◽  
Concurrent Use ◽  
Effective Training ◽  
Longitudinal Support ◽  
The Impact

Abstract Background The re-introduction of medical students into healthcare systems struggling with the COVID-19 pandemic raises concerns as to whether they will be supported when confronted with death and dying patients in resource-limited settings and with reduced support from senior clinicians. Better understanding of how medical students respond to death and dying will inform educationalists and clinicians on how to best support them. Methods We adopt Krishna’s Systematic Evidence Based Approach to carry out a Systematic Scoping Review (SSR in SEBA) on the impact of death and dying on medical students. This structured search process and concurrent use of thematic and directed content analysis of data from six databases (Split Approach) enhances the transparency and reproducibility of this review. Results Seven thousand six hundred nineteen were identified, 149 articles reviewed and 52 articles included. The Split Approach revealed similar themes and categories that correspond to the Innate, Individual, Relational and Societal domains in the Ring Theory of Personhood. Conclusion Facing death and dying amongst their patients affect how medical students envisage their personhood. This underlines the need for timely, holistic and longitudinal support systems to ensure that problems faced are addressed early. To do so, there must be effective training and a structured support mechanism.

scholarly journals Generalization support environment for understanding ways to use English words

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Tomoko Kojiri ◽  
Takushi Yamada
Keyword(s):  
Experimental Results ◽  
Support Mechanism ◽  
Usage Situation ◽  
Target Words ◽  
Learning English

Abstract When we translate Japanese sentence into English, sometimes several English words become the candidates. However, the usage situation of these candidate words is not the same. In order to choose appropriate words from them, we need to understand the usage situation for each candidate words. Usage situation of the words can be inferred by co-existing words in their example sentences. Co-existing words in example sentences are not always the same, so in order to understand usage situation, we need to generalize co-existing words from several example sentences. However, some of us who do not consciously generalize the co-existing words do not acquire the usage situation. This paper proposes the system which provides the environment where we can explicitly generalize co-existing words (keywords) in the example sentences to acquire the usage situation of the target words. This system also has a generalization support mechanism to provide concepts of words acquired through WordNet as hints. According to the experimental results, participants who used the system in learning English words reduced the number of incorrectly choosing the words and promoted to derive the own understanding of the usage situation.

Bi-manual Haptic-based Periodontal Simulation with Finger Support and Vibrotactile Feedback

2021 ◽  
Vol 17 (1) ◽  
pp. 1-17
Author(s):  
Said Chehabeddine ◽  
Muhammad Hassan Jamil ◽  
Wanjoo Park ◽  
Dianne L. Sefo ◽  
Peter M. Loomer ◽  
...  
Keyword(s):  
New York ◽  
Medical Training ◽  
Dental Students ◽  
New York University ◽  
Haptic Interaction ◽  
Vibrotactile Feedback ◽  
Quantitative Evidence ◽  
Support Mechanism ◽  
Probing Depth ◽  
Group 2

The rise of virtual reality and haptic technologies has created exciting new applications in medical training and education. In a dental simulation, haptic technology can create the illusion of substances (teeth, gingiva, bone, etc.) by providing interaction forces within a simulated virtual world of the mouth. In this article, a haptic periodontal training simulation system, named Haptodont, is developed and evaluated for simulating periodontal probing. Thirty-two faculty members from New York University College of Dentistry were recruited and divided into three groups to evaluate three fundamental functionalities: Group 1 evaluated bi-manual 3 Degrees of Freedome (DoF) haptic interaction, Group 2 evaluated bi-manual 3 DoF haptic interaction with a finger support mechanism, and Group 3 evaluated bi-manual 3 DoF haptic interaction with finger support mechanism and vibrotactile feedback. The probe and mirror interactions were simulated with the Geomagic Touch haptic device whereas the finger support was implemented using the Novint Falcon device. The three groups conducted two probing tasks: healthy gingiva scenario with no pockets (2- to 3-mm depth) and periodontitis scenario with deep pockets (4- to 8-mm depth). Results demonstrated that experts performed comparably to clinical settings in terms of probing depth error (within 0.3 to 0.6 mm) and probing forces (less than 0.5 N). Furthermore, the finger support mechanism significantly improved the probing accuracy for periodontitis condition in the lingual region. The argument that probing the lingual region is more difficult than the buccal region is supported by quantitative evidence (significantly higher probing depth error and probing force). Further research is planned to improve the usability of the finger support, integrate the Haptodont system into the pre-clinical curriculum, and evaluate the Haptodont system with dental students as a learning tool.

scholarly journals Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3843
Author(s):  
Jeffrey R. Whiteaker ◽  
Tao Wang ◽  
Lei Zhao ◽  
Regine M. Schoenherr ◽  
Jacob J. Kennedy ◽  
...  
Keyword(s):  
Dna Damage ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Limit Of Quantification ◽  
Peripheral Blood Mononuclear ◽  
Atm Kinase ◽  
Support Mechanism ◽  
Radiation Induced ◽  
Pharmacodynamic Biomarkers ◽  
Preclinical And Clinical Studies

The ATM serine/threonine kinase (HGNC: ATM) is involved in initiation of repair of DNA double-stranded breaks, and ATM inhibitors are currently being tested as anti-cancer agents in clinical trials, where pharmacodynamic (PD) assays are crucial to help guide dose and scheduling and support mechanism of action studies. To identify and quantify PD biomarkers of ATM inhibition, we developed and analytically validated a 51-plex assay (DDR-2) quantifying protein expression and DNA damage-responsive phosphorylation. The median lower limit of quantification was 1.28 fmol, the linear range was over 3 orders of magnitude, the median inter-assay variability was 11% CV, and 86% of peptides were stable for storage prior to analysis. Use of the assay was demonstrated to quantify signaling following ionizing radiation-induced DNA damage in both immortalized lymphoblast cell lines and primary human peripheral blood mononuclear cells, identifying PD biomarkers for ATM inhibition to support preclinical and clinical studies.

Anchoring effect and energy-absorbing support mechanism of large deformation bolt

2021 ◽  
Vol 28 (2) ◽  
pp. 572-581 ◽  
Author(s):  
Tong-bin Zhao ◽  
Ming-lu Xing ◽  
Wei-yao Guo ◽  
Cun-wen Wang ◽  
Bo Wang
Keyword(s):  
Large Deformation ◽  
Support Mechanism ◽  
Anchoring Effect ◽  
Energy Absorbing

Queries and Cues: Textual Stimuli for Reflective Thinking in Digital Mind-Mapping

2021 ◽  
pp. 1-19
Author(s):  
Ting-Ju Chen ◽  
Ronak Ranjitkumar Mohanty ◽  
Vinayak Krishnamurthy
Keyword(s):  
Reflective Thinking ◽  
User Study ◽  
Prior Work ◽  
Cognitive Mechanisms ◽  
Mind Mapping ◽  
Commonsense Knowledge ◽  
Support Mechanism ◽  
Asking Questions ◽  
Mapping Task ◽  
Extended Work

Abstract Mind-mapping is useful for externalizing ideas and their relationships surrounding a central problem. However, balancing between the exploration of different aspects (breadth) of the problem with respect to the detailed exploration of each of its aspects (depth) can be challenging, especially for novices. The goal of this paper is to investigate the notion of “reflection-in-design” through a novel interactive digital mind-mapping workflow that we call “QCue”. The idea behind this workflow is to incorporate the notion of reflective thinking through two mechanisms: (1) offering suggestions to promote depth exploration through user's queries (Q), and (2) asking questions (Cue) to promote reflection for breadth exploration. This paper is an extension of our prior work where our focus was mainly on the algorithmic development and implementation of a cognitive support mechanism behind QCue enabled by ConceptNet (a graph-based rich ontology with “commonsense” knowledge). In this extended work, we first present a detailed summary of how QCue facilitated the breadth-depth balance in a mind-mapping task. Second, we present a comparison between QCue and conventional digital mind-mapping i.e. without our algorithm through a between-subjects user study. Third, we present new detailed analysis on the usage of different cognitive mechanisms provided by QCue. We further consolidate our prior quantitative analysis and build a connection with our observational analysis. Finally, we discuss in detail the different cognitive mechanisms provided by QCue to stimulate reflection in design.

Caring relationships and efficient social care provision

2015 ◽  
Vol 35 (5/6) ◽  
pp. 419-436 ◽  
Author(s):  
Sue Hollinrake ◽  
Will Thomas
Keyword(s):  
Older People ◽  
Service Providers ◽  
Care Provision ◽  
Care Providers ◽  
Budget Cuts ◽  
Caring Relationships ◽  
Content Type ◽  
Support Mechanism ◽  
Practical Implications ◽  
Insight Into

Purpose – The purpose of this paper is to understand the nature of support that helps older people continue living in their own homes for as long as they wish to. Design/methodology/approach – The research made use of a participatory approach in which service users, service providers and commissioners were involved in the design of the approach in addition to contributing to the research as participants in their own right. Findings – This paper presents analysis from the research which focuses on the importance of caring relationships for providing a support mechanism. The authors question whether budget cuts and efficiency drives within statutory care providers preclude the notion of caring relationships. Practical implications – The authors suggest, in the light of the evidence presented, that statutory service providers should acknowledge the role that caring relationships play in providing support for older people. Whilst budget cuts make providing support for caring relationships more challenging, the authors suggest that there is scope for delivering services and support in ways which promote the types of interactions which better support older people living independently. Originality/value – The analysis presented here provides a distinctive, timely and thoughtful insight into support for older people at a time when public sector budgets are under increasing pressure.

scholarly journals A Blueprint for Success: A Model for Developing Engineering Education in the UK

2014 ◽  
Vol 4 (2) ◽  
pp. 18
Author(s):  
Melanie Rose Nova King ◽  
Peter Willmot
Keyword(s):  
Engineering Education ◽  
Curriculum Design ◽  
Design Education ◽  
Historical Background ◽  
Learning Technology ◽  
Ample Evidence ◽  
Support Mechanism ◽  
Education Community ◽  
The Uk ◽  
Quality Learning

This paper details the emergence and development of the ‘Centre for Engineering and Design Education’ (CEDE) at Loughborough University, UK, and provides a blueprint for success. With ample evidence that such a Centre can prove to be a highly effective support mechanism for discipline-specific academics and can develop and maintain valuable national and international networks and collaborations along with considerable esteem for the host university. The CEDE is unique in the UK and has achieved considerable success and recognition within the local engineering education community and beyond for the past 16 years. Here we discuss the historical background of the Centre’s development, the context in which it operates, and its effective management and operation strategy. The success it has enjoyed is described through examples, with much evidence of the generation of a significant amount of external funding; the development of high quality learning spaces; learning technology systems, open source software and improvements in curriculum design; a strong record of research and publication on the pedagogy of engineering; strong links with industry and employers; and a wealth of connections and know-how built up over the years. This paper provides the institutions with a model blueprint for success in developing engineering education.

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