scholarly journals Parametry metabolizma i gemostazapri endogennom giperkortitsizme s narusheniemuglevodnogo obmena

2011 ◽  
Vol 8 (3) ◽  
pp. 26-29
Author(s):  
G G Petrik ◽  
S A Pavlishchuk
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Adrenal Gland ◽  
Low Density Lipoproteins ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Low Density ◽  
Average Volume ◽  
Chronic Hyperglycemia ◽  
The Impact

The aim of the study was to determine peculiarities of protein and lipid metabolism as well as platelet-coagulation hemostasis depending on the pathogenesis of the endogenous hypercortisolism and assessment of the impact of chronic hyperglycemia on studied parameters. Materials and methods. The study included 19 patients with pituitary microadenomas with median age of 45,0 (41; 49) years and 9 patients with nodular adrenal gland hyperplasia aged 49,5 (42; 57) years, 14 of whom had diabetes mellitus. Results. Biochemical and coagulation parameters in patients with endogenous hyperpercortisolism regardless of ethiology Cushing`s syndrome differed from the control group in increased concentration of total cholesterol, high-density lipoproteins, low-density lipoproteins, alpha2-globulins and decreased gamma globulins, as well as in increased average volume of platelets and enhanced aggregation properties. Carbohydrate metabolism disorders were not characterized by significant differences in metabolic parameters and platelet hemostasis, but were accompanied by the reduction of APTT.

scholarly journals Effect of chronic hyperglycaemia on the parameters of protein, lipid metabolism and platelet-coagulation haemostasis in acromegaly

2011 ◽  
Vol 8 (4) ◽  
pp. 23-27
Author(s):  
G G Petrik ◽  
S A Pavlishchuk
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Active Phase ◽  
High Density ◽  
Atherogenic Dyslipidemia ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Chronic Hyperglycemia ◽  
The Impact

The aim of the research. Assessing the impact of chronic hyperglycemia on the parameters of the protein, lipid metabolism and platelet-coagulation haemostasis in patients with active phase of acromegaly. Materials and methods: The research included 58 patients with the active phase of acromegaly (36 women and 28 men), median age 50 (43, 57) years, disease duration 9.0 (5.0, 15.0) years, 26 of whom had verified diabetes mellitus. Results: Biochemical parameters and parameters of haemostasis in patients with active phase of acromegaly with normoglycemia differed from the control group by higher levels of total cholesterol, high-density lipoproteins, an increase in the average volume of platelet aggregation and enhancement of their function. The presence of diabetes mellitus was accompanied by the increase in concentration of total cholesterol, triglycerides, decrease in high-density lipoproteins, and increase in fibrinogen concentration, soluble fibrin-monomeasured complexes, as well as reduction of disaggregation properties of platelets and enhancement of ejection reactions. Conclusion: The presence of diabetes mellitus with acromegaly can be regarded as a significant risk factor for atherogenic dyslipidemia, hyperfibrinogenemia and platelet disfunction.

scholarly journals Blood cells and their effect on the lipid profile in women with essential hypertension

2020 ◽  
Vol 25 (3) ◽  
pp. 3349
Author(s):  
B. I. Kuznik ◽  
E. S. Guseva ◽  
S. O. Davydov ◽  
Yu. N. Smolyakov ◽  
E. V. Roitman ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Lipid Metabolism ◽  
Antihypertensive Therapy ◽  
Blood Cells ◽  
Low Density Lipoproteins ◽  
Negative Association ◽  
Atherogenic Index ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Healthy Women

Aim. To find out the relationship of particular blood cells (BC) and their ratios with lipid metabolism in patients with essential hypertension (EH), with (EH-1) and without kinesiotherapy (EH-2).Material and methods. The study included 30 healthy women (control group) and 72 women with EH, which were divided into 2 groups: group 1 (EH-1) — 37 women with stage II (target organ damage classification) hypertension who receive antihypertensive therapy; group 2 (EH-2) — 35 women who underwent antihypertensive therapy and kinesiotherapy (3-4 courses for 2-3 years).Results. Correlation analysis revealed that the studied relationships in healthy women, EH-1 and EH-2 women can be either direct or inverse. In healthy women, we observed negative association of monocytes (MON) with atherogenic index (AI), a positive association of basophils (BAS) with high density lipoproteins (HDL) and its negative association with low density lipoproteins (LDL), very low density lipoproteins (VLDL) and AI and red blood cells/platelets (RBC/PLT ratio) with HDL. Negative associations of lymphocytes (LYM)/BAS ratio with triglyceride (TG) and eosinophils (EOS)/BAS ratio with LDL were also detected. Patients with EH-1 had a direct relationship between LYM/EOS ratio and TG. In patients with EH-2, a negative relationship was found between PLT and HDL, MON and HDL, neutrophils (NEU)/MON ratio and TAG, and a positive — between white blood cells (WBC), NEU, MON and AI, LYM and TAG, MON and TAG, as well as AI.Conclusion. The obtained data indicate that all BC and their ratios in women with/without EH and with/without kinesiotherapy affect the lipid metabolism.

Abstract 537: Lipoproteins Transport Functional Non-human Small RNAs that Regulate Gene Networks Spanning Inflammation and Lipid Metabolism

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Ryan M Allen ◽  
Shilin Zhao ◽  
Quanhu Sheng ◽  
MacRae F Linton ◽  
Kasey C Vickers
Keyword(s):  
Lipid Metabolism ◽  
Nucleic Acid ◽  
Gene Networks ◽  
Financial Burden ◽  
Low Density Lipoproteins ◽  
Locked Nucleic Acid ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Mrna Targets ◽  
Regulate Gene

Cardiovascular disease (CVD) is a significant health and financial burden to our society that demands new and more effective therapies. Although dyslipidemias are primary risk factors for CVD, alternative lipoprotein functions also contribute to CVD and warrant greater understanding. We have found that high-density lipoproteins (HDL) transport microRNAs (miRNA) in circulation and HDL-miRNA signatures are significantly altered in hypercholesterolemia and atherosclerosis. Moreover, we found that HDL transfers extracellular miRNAs to recipient cells where they regulate gene expression through post-transcriptional repression of mRNA targets. We used high-throughput small RNA (sRNA) sequencing to identify and quantify miRNAs and novel sRNAs on HDL and other lipoproteins. Most interestingly, we found that the majority of sRNAs on lipoproteins are likely derived from non-human organisms of multiple kingdoms. Based on these observations, we hypothesized that human and non-human sRNAs on lipoproteins are unique regulators of gene networks that contribute to the complex pathophysiology of CVD. To assess this hypothesis, highly pure lipoproteins (HDL, low-density lipoproteins (LDL), and very low-density lipoproteins (VLDL)) were isolated from plasma of hypercholesterolemic (heterozygous familial hypercholesterolemia, n=9) and healthy (n=7) subjects. We found that HDL, LDL, and VLDL each transport unique sRNA signatures, which are differentially altered in hypercholesterolemic subjects. Using a human tissue library, we identified tissues that likely take up non-human sRNAs. We also found that each class of lipoprotein is capable of transferring non-human sRNAs to multiple cell types, and that transfer efficiency is altered in hypercholesterolemia. Lastly, using a combination of in vitro over-expression and locked-nucleic-acid inhibition for candidate, lipoprotein-enriched, non-human sRNAs, we have discovered novel regulatory networks for critical genes in inflammation and lipid metabolism. This work demonstrates that lipoprotein transport of endogenous and exogenous sRNAs likely have complex roles in the progression and resolution of CVD and are a source of untapped potential for nucleic-acid based therapeutics.

scholarly journals Changes in lipid metabolism in the pre- and postoperative periods in obese patients with laparoscopic cholecystectomy

2021 ◽  
Vol 17 (1) ◽  
pp. 55-58
Author(s):  
A.O. Maisuradze ◽  
I.V. Chubuk
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Low Density Lipoproteins ◽  
The Body ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Obese Patients ◽  
Obese People ◽  
Group 1

Background. Changes in lipid metabolism indicators in the pre- and postoperative periods are due to frequent metabolic disorders in obese people and particular difficulties with the selection of appropriate therapy. In turn, the cause for metabolic changes in the body is the influence of a certain extreme situation — surgical intervention. Objective: to study the changes in lipid metabolism in the pre- and postoperative periods in obese patients with laparoscopic cholecystectomy. Materials and methods. The study involved 50 individuals (mean age — 47.0 ± 1.5 years), who underwent surgery for acute cholecystitis by laparoscopic cholecystectomy. The patients were divided into 2 groups: 1 — obese, 2 — non-obese. The level of triglycerides, total cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL) was assessed in all patients and compared in the preoperative period and on days 1 and 5 after surgery. Results. The parameters of lipid metabolism in the pre- and postoperative periods in all groups had permissible fluctuations, given the fact that in obese patients lipids were initially increased compared to patients without obesity. In the postoperative period in group 1 on the first day, there was a decrease in triglycerides (1.1 ± 0.6 mmol/L) from the baseline, in total cholesterol (4.5 ± 0.3 mmol/L), an increase in HDL cholesterol (1.5 ± 0.2 mmol/L), a decrease in LDL (2.9 ± 0.2 mmol/L) and VLDL (1.0 ± 0.2 mmol/L). In group 2, indicators of triglyceri­des (0.6 ± 0.2 mmol/L), total cholesterol (3.4 ± 0.1 mmol/L), LDL (1.9 ± 0.3 mmol/L) and VLDL (0.8 ± 0.2 mmol/L) also tended to decrease and there was an increase in HDL (1.6 ± 0.1 mmol/L), but these values, regardless of their variation, were within the normal range. In group 1, three patients showed cognitive impairment, which was due to a significant increase in LDL over HDL and the possible development of atherosclerosis, which could lead to cerebrovascular accident. Conclusions. After conducting a study between two groups in which the lipids were studied, a variation in parame­ters was revealed in both groups, which is due to the characteristics of metabolism in such patients and the influence of surgical stress. Based on this, control and regulation of lipid values should be carried out in all patients with dyslipidemia, and in obese patients, additional consideration should be given to risk factors, concomitant diseases and possible complications.

The therapeutic effect of some drugs and vegetable juices on the lipid profiles in male rabbits induced atherosclerosis.

2019 ◽  
Vol 9 (o3) ◽  
Author(s):  
Sawsan Taha Ahmed al-Haddad ◽  
Zaid Mohammed Mubarak Almahdawi ◽  
Munife S. Ahmed Al-janabi
Keyword(s):  
Green Tea ◽  
Density Lipoprotein ◽  
Lemon Juice ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Group 5

This study was designed to test the therapeutic efficacy of some hypotensive drugs and vegetable drinks on some biochemical indicators in male rabbits, where atherosclerosis was developed using 1% cholesterol with food. This study was conducted in June until the end of July 2017 in the Pharmacology Department/ General Company for Pharmaceutical Industry in Samarra. In the study, 50 local rabbits were randomly distributed by 10 groups each containing 5 animals. The first group considered as the control group. The second group is the control group treated with 1% cholesterol with the food, the third group treated with cholesterol (1% and captopril 0.71 mg), group 4 (cholesterol 1% with atenolol 0.71 mg / kg), group 5 (cholesterol 1%, amlodipine 0.07 mg / kg) , group 6 treated with cholesterol 1% and aldomet (0.57 mg / kg), group 7 (cholesterol 1% and furosemide at 3.5 mg / kg), group 8 (cholesterol 1% with garlic syrup 2 ml), group 9 treatment cholesterol 1% and lemon juice), and group 10 Treatment with (1% cholesterol and green tea syrup 2 ml). The results of the study showed a significant increase (P≤0.01)) at the level of each of cholesterol triple and triglycerides, proteins and low density lipoproteins, very low density lipoproteins, also led to obtain a significant decrease in the level of high-density lipoproteins (HDL) in the treatment group with cholesterol 1% compared to control group. At the time of the treatment of anti- pressure drugs: Captopril, Atenolol, Amlodipine ,Aldomet, and Furosmide , there were no significant differences in the cholesterol level of all pharmacological groups. Moral differences were not found in LDL-C and there was a significant decrease (P≤0.01) of the level of triglycerides, proteins and very low density lipoproteins, and there was a significant increase in the level of high-density lipoproteins HDL-C, while treatment with plant juices, there was a significant decrease (P≤0.01) in the level of total cholesterol and triglycerides and LDL, and VLDL, high-density lipoprotein (HDL-C) increased when treated with garlic, lemon and green tea. We conclude pressure drugs of any kind can cure atherosclerosis or prevent high fat, unlike its counterparts OF plants, which have shown a significant effect on controlling lipid profile and reducing their effects and future risks on the heart.

scholarly journals STUDY OF THE EFFECT OF CHITOSAN EXTRACTED FROM THE MUSHROOM ON THE EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN MALE RABBITS

2021 ◽  
Vol 13 (2) ◽  
pp. 79-88
Author(s):  
إبراهيم خلف حميد الدليمي ◽  
◽  
أسماء هاشم شاكر ◽  
فهد خلف ياسين ◽  
◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Research Study ◽  
Low Density Lipoproteins ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Glucose Levels ◽  
Significant Difference ◽  
Therapeutic Evaluation

The present study aimed to identify the therapeutic evaluation of chitosan extracted from the fungus cushroom and pure chitosan on glucose and lipid profile in the blood of 35 male rabbits with hyperlipidemia induced experimentally by cholesterol. The tests included estimation of glucose levels, total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, and very low-density lipoproteins. hyperlipidemia was induced in the male rabbits used in the study which was administered orally with cholesterol 150mg/kg body weight for a week. rabbits were divided into seven groups: control, cholesterol, pure chitosan, mushroom chitosan, cholesterol and pure chitosan, cholesterol and mushroom chitosan and cholesterol and simvastatin. The results of the study showed, the hyperlipidemia induced experimentally resulted a significant increase (P<0.05) in TC, TG, LDL, and VLDL, while no significant difference in HDL compared with control group, on the otherwise the glucose level significantly increase than control. Also, groups of animals treatment with pure chitosan and mushroom chitosan showed a significant decrease (P<0.05) in glucose, TC, TG, LDL, and VLDL, and no significant difference in HDL compared with control group. While, the groups showed treatment with cholesterol and pure chitosan, cholesterol and mushroom chitosan, cholesterol and simvastatin a significant decrease (P<0.05) in glucose, TC, TG, LDL, and VLDL, and a significant increase (P<0.05) in HDL compared with the cholesterol group. The research study revealed that chitosan extracted from mushroom can control the levels of fat concentrations and their complications, in addition to its important role in biochemical variables, and treatment of most disease cases, especially cardiovascular disease.

scholarly journals THE PECULARITIES OF CORRELATION BETWEEN INSULIN RESISTANCE, CARBOHYDRATE AND LIPID METABOLISM INDICES IN PATIENTS WITH GRAVES’DISEASE

2017 ◽  
Vol 1 ◽  
pp. 3-9
Author(s):  
Orysia Lishchuk ◽  
Olesya Kikhtyak ◽  
Khrystyna Moskva
Keyword(s):  
Insulin Resistance ◽  
Lipid Metabolism ◽  
Thyroid Stimulating Hormone ◽  
Low Density Lipoproteins ◽  
High Density ◽  
Free Thyroxine ◽  
High Density Lipoproteins ◽  
Graves Disease ◽  
Low Density ◽  
Stimulating Hormone

Aim. The number of patients with endocrine disorders in the world, in particular, Graves’ disease is continuously increasing. Recent studies have determined the fact of insulin resistance in thyroid disorders. On the one hand, numerous researches prove correlation of hypothyroidism with arterial hypertension, ischaemic heart disease and lipid metabolism disorder, on the other – carbohydrate metabolism disorder and hyper-sympathicotonia are closely associated with hyperthyroidism. The subject of the research was to study the correlation of insulin resistance, lipid and carbohydrate metabolism indices in patients with Graves’disease. Material and Methods. During the study 53 (37 female and 16 male) patients with Graves’ disease with noticed IR have been examined. At the beginning, after 3– and 6-months thyreostatic therapy with insulin sensitizers (metformin or pioglitazone) the following investigations have been performed: assessing thyroid-stimulating hormone levels, free thyroxine and triiodothyronine; assessing glycated haemoglobin, glucose, C-peptide and fasting insulin as primary IR markers; calculating НОМА-IR index for analysing tissue sensitivity to insulin; calculating НОМА-β index for evaluating the functional capacity of β-cells of islets of Langerhans; measuring Caro indices to monitor hyperinsulinemia, measuring total cholesterol level, low-density lipoproteins, very-low-density lipoproteins, high-density lipoproteins , triglycerides, for analysing IR in relation to lipid metabolism. Results. The research results found out that free thyroid hormones and thyroid-stimulating hormone are closely related to lipid metabolism. Thus, thyroid-stimulating hormone was characterized as having direct correlation with low-density lipoproteins, while the free thyroxine inversely correlated with total cholesterol, low-density lipoproteins, and high-density lipoproteins. The free triiodothyronine negatively correlated with high-density lipoproteins. The research has also determined the direct correlation between insulin and free thyroxine, as well as free triiodothyronine in patients with diffuse toxic goitre. Conclusions. The study proves the presence of insulin resistance in patients with Graves’ disease that generates interest to further study of the changes in insulin sensitivity, relation of insulin resistance to thyroid-stimulating hormone, thyroid hormones and looking for the ways to correct these disorders.

scholarly journals Effect of Different Level of Zeolite and Perlite on The Physiological Performance of Awassi Lambs

2021 ◽  
Vol 923 (1) ◽  
pp. 012039
Author(s):  
Asaad Fadhel Tarsh ◽  
Ahmed Jawad Al-Yasseri
Keyword(s):  
Blood Parameters ◽  
Low Density Lipoproteins ◽  
The Other ◽  
Physiological Traits ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Low Density ◽  
The Third ◽  
Awassi Sheep ◽  
Awassi Lambs

Abstract A total of 24 male Awassi lamb aged (4-6) months were used, to determine the effect of different level of zeolite and perlite on the physiological traits of Awassi sheep. Results show that te use of zeolite led to the presence of high significant differences at the level (P ≤ 0.05) of the studied values between the experimental groups and according to the weeks of the study, as the values varied between different weeks in the characteristics of the biochemical blood parameters and values, which are (both cholesterol values, the values of high-density lipoproteins, low-density lipoproteins, and fats). All treatments of zeolite and perylite and their mixture outperformed the control group, while the fourth treatment T4 outperformed the other treatments, followed by the third treatment T3 over the studied treatments T2 and T1.

scholarly journals Efeito da redução de peso em pacientes submetidos à técnica do Bypass Gástrico em Y-de-Roux

2019 ◽  
Vol 28 (1) ◽  
pp. 11
Author(s):  
Midia Alves Farias de Melo ◽  
Tatiane Dos Santos ◽  
Luiny Godoy ◽  
Ketlen Silva ◽  
Thais Regina Mezzomo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density

ObjetivoIdentificar o impacto da cirurgia bariátrica sobre o perfil metabólico de indivíduos submetidos ao Bypass Gástrico em Y-de Roux. MétodosAnálise retrospectiva do período pré- e pós-operatório de cinquenta e três pacientes submetidos à técnica cirúrgica Bypass Gástrico em Y-de-Roux, com idade entre 18 e 63 anos, atendidos em um Centro de Saúde Preventiva do Município de Curitiba, Paraná. Foram coletados dados antropométricos e laboratoriais de Low Density Lipoproteins, High Density Lipoproteins, triglicérides, glicose de jejum e insulina de jejum no período pré- e pós-operatório (6 meses, 12 meses e 24 meses) de prontuários médicos. ResultadosEntre os pacientes, 94,34% (n=50) eram mulheres com idade média de 45,04±9,17 anos. Foi observada redução significativa do peso e índice de massa corporal, assim como concentrações inferiores de glicose sérica. O colesterol total (192,19±38,66 vs 162,38±30,42, p=<0,05), low density lipoproteins (119,81±31,68 vs 95,10±22,77), e Triglicérides (153,11±84,10 vs 80,64±35,52, p<0,01) quando comparados os períodos pré-operatório e pós-operatório (24 meses). No pós-operatório de 24 meses foi observada remissão da hipertensão arterial, diabetes Mellitus e dislipidemia, sendo a obesidade mais comum no pós-operatório de 2 anos estando presente em 21,00% dos pacientes. ConclusãoO Bypass Gástrico em Y-de-Roux mostrou ser um procedimento eficaz na melhora do perfil metabólico de indivíduos com obesidade mórbida, com resultados consistentes na perda de peso e remissão das principais comorbidades associadas à obesidade.

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