Branching Process Modelling of COVID-19 Pandemic Including Immunity and Vaccination

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Dimitar Atanasov ◽  
Vessela Stoimenova ◽  
Nikolay M. Yanev
Keyword(s):  
Branching Process ◽  
Branching Processes ◽  
Data Availability ◽  
Model Parameters ◽  
Reproduction Rate ◽  
Direct Computation ◽  
Infection Dynamics ◽  
Secondary Infections ◽  
Proposed Model ◽  
The Mean

Abstract We propose modeling COVID-19 infection dynamics using a class of two-type branching processes. These models require only observations on daily statistics to estimate the average number of secondary infections caused by a host and to predict the mean number of the non-observed infected individuals. The development of the epidemic process depends on the reproduction rate as well as on additional facets as immigration, adaptive immunity, and vaccination. Usually, in the existing deterministic and stochastic models, the officially reported and publicly available data are not sufficient for estimating model parameters. An important advantage of the proposed model, in addition to its simplicity, is the possibility of direct computation of its parameters estimates from the daily available data. We illustrate the proposed model and the corresponding data analysis with data from Bulgaria, however they are not limited to Bulgaria and can be applied to other countries subject to data availability.

scholarly journals A New Extended Two-Parameter Distribution: Properties, Estimation Methods, and Applications in Medicine and Geology

Mathematics ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1578 ◽  
Author(s):  
Hazem Al-Mofleh ◽  
Ahmed Z. Afify ◽  
Noor Akma Ibrahim
Keyword(s):  
Estimation Method ◽  
Estimation Methods ◽  
Parameter Distribution ◽  
Model Parameters ◽  
Unknown Parameters ◽  
Proposed Model ◽  
Rate Functions ◽  
The Mean ◽  
Modeling Data ◽  
Two Parameter

In this paper, a new two-parameter generalized Ramos–Louzada distribution is proposed. The proposed model provides more flexibility in modeling data with increasing, decreasing, J-shaped, and reversed-J shaped hazard rate functions. Several statistical properties of the model were derived. The unknown parameters of the new distribution were explored using eight frequentist estimation approaches. These approaches are important for developing guidelines to choose the best method of estimation for the model parameters, which would be of great interest to practitioners and applied statisticians. Detailed numerical simulations are presented to examine the bias and the mean square error of the proposed estimators. The best estimation method and ordering performance of the estimators were determined using the partial and overall ranks of all estimation methods for various parameter combinations. The performance of the proposed distribution is illustrated using two real datasets from the fields of medicine and geology, and both datasets show that the new model is more appropriate as compared to the Marshall–Olkin exponential, exponentiated exponential, beta exponential, gamma, Poisson–Lomax, Lindley geometric, generalized Lindley, and Lindley distributions, among others.

Asymptotic behaviour of immigration-branching processes by general set of types. II: Supercritical branching part

1975 ◽  
Vol 7 (03) ◽  
pp. 468-494
Author(s):  
H. Hering
Keyword(s):  
Branching Process ◽  
Branching Processes ◽  
Almost Sure Convergence ◽  
Transition Function ◽  
Mean Square ◽  
Second Moments ◽  
Mean Square Convergence ◽  
The Mean ◽  
Parameter Dependent ◽  
Dependent Probability

We construct an immigration-branching process from an inhomogeneous Poisson process, a parameter-dependent probability distribution of populations and a Markov branching process with homogeneous transition function. The set of types is arbitrary, and the parameter is allowed to be discrete or continuous. Assuming a supercritical branching part with primitive first moments and finite second moments, we prove propositions on the mean square convergence and the almost sure convergence of normalized averaging processes associated with the immigration-branching process.

scholarly journals Modeling Y-Linked Pedigrees through Branching Processes

Mathematics ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 256
Author(s):  
Miguel González ◽  
Cristina Gutiérrez ◽  
Rodrigo Martínez
Keyword(s):  
Hearing Loss ◽  
Asymptotic Behavior ◽  
Gibbs Sampler ◽  
Mutant Allele ◽  
Branching Process ◽  
Branching Processes ◽  
Dominant Allele ◽  
Linked Gene ◽  
Different Types ◽  
The Mean

A multidimensional two-sex branching process is introduced to model the evolution of a pedigree originating from the mutation of an allele of a Y-linked gene in a monogamous population. The study of the extinction of the mutant allele and the analysis of the dominant allele in the pedigree is addressed on the basis of the classical theory of multi-type branching processes. The asymptotic behavior of the number of couples of different types in the pedigree is also derived. Finally, using the estimates of the mean growth rates of the allele and its mutation provided by a Gibbs sampler, a real Y-linked pedigree associated with hearing loss is analyzed, concluding that this mutation will persist in the population although without dominating the pedigree.

Asymptotic behaviour of population-size-dependent branching processes in Markovian random environments

1999 ◽  
Vol 36 (2) ◽  
pp. 611-619 ◽  
Author(s):  
Han-Xing Wang ◽  
Dafan Fang
Keyword(s):  
Asymptotic Behaviour ◽  
Population Size ◽  
Branching Process ◽  
Branching Processes ◽  
Random Environments ◽  
Real Numbers ◽  
Size Dependent ◽  
Recurrent Markov Chain ◽  
The Mean ◽  
Positive Recurrent

A population-size-dependent branching process {Zn} is considered where the population's evolution is controlled by a Markovian environment process {ξn}. For this model, let mk,θ and be the mean and the variance respectively of the offspring distribution when the population size is k and a environment θ is given. Let B = {ω : Zn(ω) = 0 for some n} and q = P(B). The asymptotic behaviour of limnZn and is studied in the case where supθ|mk,θ − mθ| → 0 for some real numbers {mθ} such that infθmθ > 1. When the environmental sequence {ξn} is a irreducible positive recurrent Markov chain (particularly, when its state space is finite), certain extinction (q = 1) and non-certain extinction (q < 1) are studied.

scholarly journals Contagions in random networks with overlapping communities

2015 ◽  
Vol 47 (4) ◽  
pp. 973-988 ◽  
Author(s):  
Emilie Coupechoux ◽  
Marc Lelarge
Keyword(s):  
Phase Transition ◽  
Random Graph ◽  
Epidemic Model ◽  
Branching Process ◽  
Branching Processes ◽  
Graph Model ◽  
Single Individual ◽  
Overlapping Communities ◽  
Random Graph Model ◽  
The Mean

We consider a threshold epidemic model on a clustered random graph model obtained from local transformations in an alternating branching process that approximates a bipartite graph. In other words, our epidemic model is such that an individual becomes infected as soon as the proportion of his/her infected neighbors exceeds the threshold q of the epidemic. In our random graph model, each individual can belong to several communities. The distributions for the community sizes and the number of communities an individual belongs to are arbitrary. We consider the case where the epidemic starts from a single individual, and we prove a phase transition (when the parameter q of the model varies) for the appearance of a cascade, i.e. when the epidemic can be propagated to an infinite part of the population. More precisely, we show that our epidemic is entirely described by a multi-type (and alternating) branching process, and then we apply Sevastyanov's theorem about the phase transition of multi-type Galton-Watson branching processes. In addition, we compute the entries of the mean progeny matrix corresponding to the epidemic. The phase transition for the contagion is given in terms of the largest eigenvalue of this matrix.

scholarly journals A Size-Perimeter Discrete Growth Model for Percolation Clusters

Complexity ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Bendegúz Dezső Bak ◽  
Tamás Kalmár-Nagy
Keyword(s):  
Growth Model ◽  
Branching Process ◽  
Growth Models ◽  
Square Lattice ◽  
Cluster Growth ◽  
Invasion Percolation ◽  
Percolation Clusters ◽  
Proposed Model ◽  
Wide Range ◽  
The Mean

Cluster growth models are utilized for a wide range of scientific and engineering applications, including modeling epidemics and the dynamics of liquid propagation in porous media. Invasion percolation is a stochastic branching process in which a network of sites is getting occupied that leads to the formation of clusters (group of interconnected, occupied sites). The occupation of sites is governed by their resistance distribution; the invasion annexes the sites with the least resistance. An iterative cluster growth model is considered for computing the expected size and perimeter of the growing cluster. A necessary ingredient of the model is the description of the mean perimeter as the function of the cluster size. We propose such a relationship for the site square lattice. The proposed model exhibits (by design) the expected phase transition of percolation models, i.e., it diverges at the percolation threshold p c . We describe an application for the porosimetry percolation model. The calculations of the cluster growth model compare well with simulation results.

Adjusting a subject-specific time of event in longitudinal studies

2019 ◽  
Vol 29 (7) ◽  
pp. 1787-1798
Author(s):  
Hyunkeun Ryan Cho ◽  
Seonjin Kim ◽  
Myung Hee Lee
Keyword(s):  
Goodness Of Fit ◽  
Real Life ◽  
Model Parameters ◽  
Specific Time ◽  
Goodness Of Fit Test ◽  
Proposed Model ◽  
Subject Specific ◽  
The Subject ◽  
The Mean ◽  
Over Time

Biomedical studies often involve an event that occurs to individuals at different times and has a significant influence on individual trajectories of response variables over time. We propose a statistical model to capture the mean trajectory alteration caused by not only the occurrence of the event but also the subject-specific time of the event. The proposed model provides a post-event mean trajectory smoothly connected with the pre-event mean trajectory by allowing the model parameters associated with the post-event mean trajectory to vary over time of the event. A goodness-of-fit test is considered to investigate how well the proposed model is fit to the data. Hypothesis tests are also developed to assess the influence of the subject-specific time of event on the mean trajectory. Theoretical and simulation studies confirm that the proposed tests choose the correctly specified model consistently and examine the effect of the subject-specific time of event successfully. The proposed model and tests are also illustrated by the analysis of two real-life data from a biomarker study for HIV patients along with their own time of treatment initiation and a body fatness study in girls with different age of menarche.

Geometric rate of growth in population-size-dependent branching processes

1984 ◽  
Vol 21 (01) ◽  
pp. 40-49 ◽  
Author(s):  
F. C. Klebaner
Keyword(s):  
Population Size ◽  
Process Model ◽  
Branching Process ◽  
Necessary Conditions ◽  
Branching Processes ◽  
Sufficient Conditions ◽  
Almost Sure Convergence ◽  
Size Dependent ◽  
Offspring Distribution ◽  
The Mean

We consider a branching-process model {Zn }, where the law of offspring distribution depends on the population size. We consider the case when the means mn (mn is the mean of offspring distribution when the population size is equal to n) tend to a limit m &gt; 1 as n →∞. For a certain class of processes {Zn } necessary conditions for convergence in L 1 and L 2 and sufficient conditions for almost sure convergence and convergence in L 2 of Wn = Zn/mn are given.

scholarly journals Reliability prediction of the axial ultimate bearing capacity of piles: A hierarchical Bayesian method

2018 ◽  
Vol 10 (11) ◽  
pp. 168781401881105
Author(s):  
Shengliang Lu ◽  
Jie Zhang ◽  
Shirong Zhou ◽  
Ancha Xu
Keyword(s):  
Bearing Capacity ◽  
Soil Layer ◽  
Ultimate Bearing Capacity ◽  
Model Parameters ◽  
Hierarchical Bayesian ◽  
Land Resources ◽  
Proposed Model ◽  
The Mean ◽  
Sea Reclamation ◽  
Hierarchical Bayesian Method

The sea reclamation is one of the efficient ways to alleviate the shortage of land resources due to population growth, and the corresponding axial ultimate bearing capacity of piles has become one of the critical factors for evaluating the performance of the soil layer reclamation work. Many models are used to analyze the testing data. However, these models cannot describe the mean population bearing capacity and unit-to-unit variation simultaneously, and they cannot give the reliability of predicting the axial ultimate bearing capacity of piles. Thus, they are rarely used in practice. In this article, we propose a mixed-effects model, which could overcome the drawback of the models in the literature. A hierarchical Bayesian framework is developed to estimate the model parameters using Gibbs sampling. The proposed model is applied to a real pile dataset collected in silt-rock layer area, and we predict the mean axial bearing capacities under different reliability levels.

Asymptotic behaviour of population-size-dependent branching processes in Markovian random environments

1999 ◽  
Vol 36 (02) ◽  
pp. 611-619 ◽  
Author(s):  
Han-Xing Wang ◽  
Dafan Fang
Keyword(s):  
Asymptotic Behaviour ◽  
Population Size ◽  
Branching Process ◽  
Branching Processes ◽  
Random Environments ◽  
Real Numbers ◽  
Size Dependent ◽  
Recurrent Markov Chain ◽  
The Mean ◽  
Positive Recurrent

A population-size-dependent branching process {Z n } is considered where the population's evolution is controlled by a Markovian environment process {ξ n }. For this model, let m k,θ and be the mean and the variance respectively of the offspring distribution when the population size is k and a environment θ is given. Let B = {ω : Z n (ω) = 0 for some n} and q = P(B). The asymptotic behaviour of lim n Z n and is studied in the case where supθ|m k,θ − m θ| → 0 for some real numbers {m θ} such that infθ m θ &gt; 1. When the environmental sequence {ξ n } is a irreducible positive recurrent Markov chain (particularly, when its state space is finite), certain extinction (q = 1) and non-certain extinction (q &lt; 1) are studied.

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