The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Nazanin Majidi ◽  
Mahboubeh Kosari Monfared ◽  
Fatemeh Mazaheri-Eftekhar ◽  
Ariyo Movahedi ◽  
Majid Karandish
Keyword(s):  
Weight Gain ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Normal Group ◽  
Inflammatory Factors ◽  
Control Group ◽  
Rose Petal ◽  
Rose Petals ◽  
Damask Rose ◽  
Hs Crp

Abstract Objectives Diabetes is a chronic disease caused by high blood sugar greatly affected by diet. The chemical medicines applied to treat diabetes usually have side effects. This study aimed to investigate the effect of saffron petals, damask rose petals, and saffron-damask rose petal herbal teas on weight loss, fasting blood sugar, lipid profile, and the inflammatory factors of diabetic rats. Methods In this study, 40 male Sprague Dawley rats with an average age of four weeks received a high-calorie, high-fat, high-sugar diet for nine weeks. The rats were then randomly assigned to five groups, including normal, control, saffron petal, damask rose petal, and saffron plus damask rose petal groups. For nine weeks, 3 mL of the herbal tea was administered to the intervention groups daily through oral gavage. The levels of FBS, lipid profile, Insulin-like growth factor 1 (IGF-1), the high-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1C), and glucose tolerance test (GTT) were measured following the intervention. Results Saffron petals reduced weight gain, Triglyceride (TG), and HbA1c and increased hs-CRP and IGF-1 (all p < 0.05). The damask rose petal reduced weight gain, FBS, hs-CRP, and HbA1c and increased the IGF-1 (all p < 0.05). Saffron plus damask-rose petals reduced the weight gain, TG, hs-CRP and HbA1c, and increase IGF-1 factor (all p < 0.05) compared to the control group. No significant effect was found on visceral fat, LDL-C, and HDL-C. Compared with the normal group, saffron petals and damask rose petals increased the FBS, HDL, and LDL levels. Damask rose and the combination of saffron petals and damask rose decreased IGF-1 compared with the normal group (all p < 0.05). Conclusions Saffron and damask rose petals could have beneficial effects on improving the status of biochemical markers. The simultaneous use of saffron and damask rose may counteract the adverse effects of saffron on inflammatory indices.

scholarly journals A study on the status of serum High Sensitive C - Reactive Protein and Fasting Blood Sugar in Patients with Hyperlipidemia attending a Super Specialty Teaching Hospital in North Kerala

2020 ◽  
Vol 11 (4) ◽  
pp. 6908-6912
Author(s):  
Mohammed Muneersha T K ◽  
Saravanakumar R T ◽  
Revikumar K G ◽  
Fathima Habeeba T E ◽  
Jobin Louis ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Blood Sugar ◽  
Teaching Hospital ◽  
Blood Sugar Level ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Newly Diagnosed ◽  
Significant Difference ◽  
The Status ◽  
Hs Crp

This study was aimed to analyses the serum Hs-CRP level and fasting Blood Sugar level in patients with Hyperlipidemia in a Super Specialty Teaching Hospital in north Kerala. This was a hospital-based prospective observational study which was conducted to study the status of Hs-CRP and Fasting Blood sugar level on lipid profile status of newly diagnosed Hyperlipidemia patients which was compared with Normal Lipid Profile people. Healthy subjects were recruited as a control group and newly Diagnosed Hyperlipidemia patients were recruited as Test group. Study subjects of both gender in an age group of 30 to 70 were selected for the study. Serum Hs CRP, Fasting Blood sugar and serum lipid profile were estimated after overnight fasting condition. After the biochemical estimation, values were entered in an Excel sheet and level of test and control group was statistically analyzed by using Student's t-test using SPSS software. The values were expressed in Mean ± Standard Deviation (SD) and The status of serum Hs CRP, fasting Blood Sugar and Lipid Profile Parameters were shown a statistically significant difference (p<0.01) between Control and Test groups. The result of the study points out that the elevated level serum Hs-CRP and Fasting Blood Sugar can be used as predictive markers of Hyperlipidemia.

scholarly journals Curcumin nanomicelle versus curcumin improves lipid profile, stress oxidative factors and inflammatory markers in patients undergoing coronary elective angioplasty; A Randomized Clinical Trial

2019 ◽  
Author(s):  
Bijan Helli ◽  
Hadis Gerami ◽  
Maria Kavianpour ◽  
Habib Heybar ◽  
Seyed Kianoosh Hosseini ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lipid Profile ◽  
Inflammatory Markers ◽  
Interleukin 1 ◽  
Stress Index ◽  
Inflammatory Factors ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Stress Oxidative

Abstract Background: Curcumin exhibited antioxidant and anti-inflammatory effects. The aim of this study, assess and compare curcumin and nano- curcumin effects on lipid profile, oxidative stress index and inflammatory factors of heart patients.Methods: This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted on 90 patients undergoing coronary elective angioplasty. Patients were randomly divided into 3 groups. The first group received a 500 mg capsule of curcumin daily. The second group received an 80 mg capsule of nano- curcumin daily. The placebo group also received capsules similar to curcumin for 8 weeks. Lipid profile, stress oxidative factors and inflammatory markers measured in baseline and end of the investigation.Results: At the end of study, statistically significant changes was seen in the total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) in the intervention groups to the control group (p<0.05). These changes in the nano-curcumin group were greater than the curcumin group. Curcumin and nano-curcumin supplementation also caused a statistically significant improvement in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) in comparison to the placebo (p<0.05).Conclusion: Complementary therapy of cardiovascular patients with curcumin and nano-curcumin supplements, could improve lipid profile, stress oxidative index and, inflammatory factors. The effects of curcumin on nano formula may be better for cardiac patients due to high bioavailability. However, further investigation is suggested in this regard.

scholarly journals Dr Effects of Adiponectin, Plasma D-Dimer, Inflammation and Tumor Markers on Clinical Characteristics and Prognosis of Patients with Ovarian Cancer

2021 ◽  
Author(s):  
Hui Li
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Tumor Markers ◽  
Inflammatory Factors ◽  
Control Group ◽  
Multivariate Logistic Regression ◽  
Factors Affecting ◽  
Serum Tumor Markers ◽  
Related Risk ◽  
Hs Crp

 [Abstract] Objective: To investigate the effects of adiponectin (ADPN), plasma D-dimer (D-D), inflammation and tumor markers on clinical characteristics and prognosis of patients with ovarian cancer. Methods: A total of 80 patients with ovarian cancer treated in our hospital from April 2017 to November 2019 were enrolled as study subjects and evenly divided into observation group (patients with ovarian cancer) and control group (patients with benign ovarian tumor) based on the results of postoperative pathological biopsy. The levels of ADPN, plasma D-D, inflammatory factors and serum tumor markers [carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4) and risk of ovarian malignancy algorithm (ROMA)] were compared between the two groups. The diagnostic value of serum tumor markers CA125, HE4 and ROMA in ovarian cancer was explored. The correlations of the changes of ROMA with the changes in the levels of ADPN, plasma D-D, high-sensitivity C-reactive protein (hs-CRP), CA125 and HE4 were analyzed. Additionally, the related risk factors affecting the development of ovarian cancer were subjected to univariate and multivariate logistic regression analyses. Results: In comparison with control group, observation group exhibited a lowered ADPN level (p<0.05), notably raised levels of plasma D-D, inflammatory factors hs-CRP and interleukin-6 (IL-6) and serum tumor markers CA125 and HE4 and an evidently increased ROMA (p<0.05). Besides, the detection of serum ROMA showed the highest specificity and sensitivity and low false positive rate and false negative rate. The changes of ROMA were positively correlated with the changes in the levels of plasma D-D, hs-CRP, CA125 and HE4 (p<0.05), and negatively associated with the changes in ADPN level (p<0.05). The results of univariate analysis showed that abnormal ADPN, D-D, hs-CRP, IL-6, CA125 and HE4 levels were related risk factors affecting the development of ovarian cancer. It was found through multivariate logistic regression analysis that decreased ADPN level and increased D-D, hs-CRP, IL-6, CA125 and HE4 levels were independent risk factors affecting the development of ovarian cancer. Conclusion: In the case of ovarian cancer, the ADPN level declines, while the levels of plasma D-D, inflammatory factors, and serum tumor markers CA125, HE4 and ROMA rise obviously. Besides, the ROMA level displays a positive relation to the content of CA125, HE4, plasma D-D and inflammatory factors and a negative association with ADPN level.

scholarly journals Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism

2022 ◽  
Vol 2022 ◽  
pp. 1-13
Author(s):  
Jia Liu ◽  
Chunjing Li ◽  
Qiuyang Wang ◽  
Haiyan Hu ◽  
Chunhong Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Lipid ◽  
Normal Group ◽  
Inflammatory Factors ◽  
Control Group ◽  
Ang Ii ◽  
Toll Like Receptor ◽  
High Fat ◽  
In The Wild ◽  
Toll Like Receptor 2

According to the latest clinical data, cardiovascular diseases have ranked first in prone diseases, causing 40% of the premature deaths of China’s population. This study aimed to investigate the influence of Toll-like receptor 2- (TLR2-) mediated inflammation on the occurrence and development of familial hypertension combined with hyperlipemia and its related mechanism. Blood specimens from 66 patients undergoing coronary atherosclerosis were collected and grouped, including 22 patients into the control group, 25 into the familial hypertension group, and 19 into familial hypertension combined with hyperlipemia group. In this study, ELISA was conducted for determining the levels of four inflammatory factors of TLR2 and IL-1β, IL-6, TNF-ɑ, and CCL2 in serum and the levels of relevant indicators in mice. C57Bl/6j and genetically engineered C.129(B6)-Tlr2tm1Kir/J mice were given subcutaneous injection of normal saline (wild-saline group), 8-week 40% high-fat diet (wild-high-fat group), and subcutaneous Alzet-implanted angiotensin II micropump supplemented with the research diet (wild-high fat-Ang II group, Tlr2-/--high fat-Ang II group). Blood pressure in mice was recorded consecutively with a noninvasive hemopiezometer for eight weeks. TLR2 and IL-1β, IL-6, TNF-ɑ, and CCL2 in serum of patients with familial hypertension combined with hyperlipemia and the hypertension combined with hyperlipemia mouse model were higher than those in the normal group. Under combined intervention of Ang II and the research diet, mRNA expression related to blood pressure, blood lipid, and fat metabolism in Tlr2-/- genetically engineering mice was significantly lower than that in the wild-high fat-Ang II group. The phosphorylation levels of AKT, IKK, and p65 in mice with hypertension combined with hyperlipidemia were significantly higher than those in normal group. The levels of blood pressure and blood lipid in mice after blocking the AKT or NF-κB pathway were significantly downregulated compared with those in the wild-high fat-Ang II group, with statistically significant differences (both P < 0.05 ). In conclusion, TLR2 regulates inflammation through Akt-NF-κB pathway, thus inducing the occurrence and development of familial hypertension combined with hyperlipemia.

scholarly journals Relationship Between Curative Effect and Serum Inflammatory Factors Level in Male Patients With First-Episode Schizophrenia Treated With Olanzapine

2021 ◽  
Vol 12 ◽  
Author(s):  
Jun Ma ◽  
Yanting Zhang ◽  
Zhuowei Huang ◽  
Xuebing Liu ◽  
Luxian Lv ◽  
...  
Keyword(s):  
Serum Levels ◽  
Inflammatory Factors ◽  
First Episode ◽  
Control Group ◽  
Case Group ◽  
Therapeutic Effects ◽  
Male Patients ◽  
Hs Crp ◽  
Effective Group ◽  
First Episode Schizophrenia

Background: A growing body of evidence shows that immune system disorders are one of the important etiological factors of schizophrenia. Inflammatory cytokines play a very critical role in the pathogenesis and treatment of schizophrenia. However, in the actual clinical practice, there is still a lack of confirmed biological indicators that can be used to evaluate the therapeutic effect of antipsychotics.Methods: In this study, 82 male patients with first-episode schizophrenia and 30 healthy controls were included. The Positive and Negative Syndrome Scale (PANSS) scores were evaluated, and the serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 1β (IL-1β), interleukin 6 (IL-6), interleukin 17 (IL-17), and transforming growth factor β1 (TGF-β1) were detected, both at baseline and 4 weeks later. The patients were divided into two groups, the effective group and the ineffective group, according to the reduction rate of PANSS.Results: In the case group, the levels of hs-CRP were significantly elevated (p = 0.00), whereas IL-1β, IL-6, and IL-17 were significantly reduced as compared to the baseline (p = 0.01, 0.02, and 0.00, respectively). Importantly, the baseline levels of the five inflammatory factors were significantly higher in the case group as compared to the control group (p = 0.00, 0.00, 0.00, 0.00, and 0.00, respectively). Post-treatment, the serum levels for IL-1β, IL-6, and IL-17 were significantly higher in the effective group than in the ineffective group (p = 0.00, 0.00, and 0.01, respectively). For every increase in the amount of IL-1β, the risk of ineffectiveness increased by 7% (OR = 0.93 [0.86–1.00]; p = 0.04), whereas for every increase in the amount of IL-17, the risk of ineffectiveness increased by 5% (OR = 0.95 [0.90–0.99]; p = 0.03).Conclusion: The results of the study showed that the levels of inflammatory factors in patients with different therapeutic effects were different, and the changes in the amounts of IL-1β and IL-17 acted as predictors of poor efficacy.

scholarly journals Mecobalamin and early functional outcomes of ischemic stroke patients with H-type hypertension

2018 ◽  
Vol 64 (5) ◽  
pp. 428-432
Author(s):  
Meixia Yuan ◽  
Beiyun Wang ◽  
Shijin Tan
Keyword(s):  
Ischemic Stroke ◽  
Treatment Group ◽  
Carotid Artery ◽  
Conventional Therapy ◽  
Functional Outcomes ◽  
Inflammatory Factors ◽  
Control Group ◽  
Serum Homocysteine ◽  
The Difference ◽  
Hs Crp

SUMMARY OBJECTIVE To analyze the effect of mecobalamin on the early-functional outcomes of patients with ischemic stroke and H-type hypertension. METHODS From October of 2014 to October of 2016, 224 cases of ischemic stroke and H-type hypertension were selected. The patients were randomly divided into treatment control groups, with 112 patients in each group. The control group was treated with the conventional therapy. The observation group was treated with 500 µg of mecobalamin three times a day in addition to the conventional therapy. We compared serum homocysteine (Hcy), hs-CRP levels, carotid plaques, and NIHSS scores between the two groups on the 2nd day and at 4 weeks, 8 weeks, 3 months, and 6 months. RESULTS After 4 weeks, 8 weeks, 3 months and 6 months, the difference of serum Hcy level between the two groups was statistically significant (t = 4.049, 3.896, 6.052, 6.159, respectively. All P <0.05). After the treatment, at 4 weeks, 8 weeks, 3 months and 6 months, the levels of hs-CRP in the treatment group were significantly lower than those in the control group (t = 37.249, 28.376, 26.454, 20.522, respectively. All P <0.01). After 3 months and 6 months, the carotid artery plaques were significantly reduced in the treatment group compared to those in the control group (t = 2.309 and 2.434. All P <0.05). After 3 months and 6 months, the NIHSS score was significantly higher in the treatment group compared to those in the control group (t = 2.455 and 2.193. All P <0.05). CONCLUSION Mecobalamin can reduce the level of plasma homocysteine, then lead to reductions of levels of plasma inflammatory factors and volume of carotid artery plaques, resulting in more significant functional recovery.

Effect of green tea consumption on the metabolic syndrome indices in women: a clinical trial study

2019 ◽  
Vol 49 (1) ◽  
pp. 32-46 ◽  
Author(s):  
Fatemehbanoo Mortazavi ◽  
Zamzam Paknahad ◽  
Akbar Hasanzadeh
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Clinical Trial ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Green Tea ◽  
Density Lipoprotein ◽  
Control Group ◽  
Tea Consumption ◽  
Content Type

PurposeMetabolic syndrome (MetS) is a complex disorder that exacerbates the risk of cardiovascular disease and diabetes mellitus; some studies have indicated the beneficial effects of green tea on human health. The purpose of this study is to investigate the effects of green tea consumption on the MetS indicators in women.Design/methodology/approachA randomized clinical trial was carried out on 70 eligible women with confirmed diagnosis of MetS who visited Shabani Diabetes Clinic (Isfahan, Iran). Participants were randomly divided into two groups. Participants in the Green Tea Group were asked to consume three 200 cc of green tea in the morning, at noon and at night for eight weeks, while people in the control group were asked to take identical amount of lukewarm water at the same schedule. Anthropometric indicators, blood pressure, blood sugar, lipid profile, diet and physical activity were assessed at the beginning and the end of the study.FindingsAn independentt-test showed that weight (p =0.001), body mass index (p =0.001), waist circumference (p< 0.001) and waist–hip ratio (p =0.02), systolic blood pressure (p =0.04), fasting blood glucose (p =0.01) and low density lipoprotein (p =0.03) changed significantly more in the Green Tea Group than in the control group; but no such inter-group difference was observed in diastolic blood pressure, triglyceride, total cholesterol and high density lipoprotein (HDL) values (p> 0.05).Originality/valueRegular consumption of green tea for eight weeks significantly improved anthropometric indices, blood pressure, blood sugar and lipid profile in women with MetS. Therefore, this beverage can serve as part of an effective dietary strategy to control MetS.

scholarly journals Efficacy of krill oil versus fish oil on obesity-related parameters and lipid gene expression in rats: randomized controlled study

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12009
Author(s):  
Mevra Aydin Cil ◽  
Atena Ghosi Ghareaghaji ◽  
Yasin Bayir ◽  
Zehra Buyuktuncer ◽  
Halit Tanju Besler
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Weight Gain ◽  
Lipid Profile ◽  
Control Group ◽  
Krill Oil ◽  
Randomized Controlled ◽  
Prevention And Treatment ◽  
Treatment Of Obesity ◽  
Gene Expression Levels

Backround This study aimed to determine the effects of LC n-3 PUFA supplementation on the prevention and treatment of obesity and obesity-related diseases, and to compare the efficiency of different LC n-3 PUFA sources via biochemical and genetic mechanisms in rats. Methods Male Wistar rats were randomized into four study groups, and fed with a standard diet, High Fat Diet (HFD), HFD+%2.5 Fish Oil (FO-HFD) or HFD+%2.5 Krill Oil (KO-HFD) for eight weeks. Food consumption, weight gain, serum glucose, insulin, ghrelin and leptin concentrations, lipid profile, liver fatty acid composition, and FADS1 and FADS2 mRNA gene expression levels were measured. Results Weight gain in each HFD group was significantly higher than control group (p < 0.001), without any differences among them (p < 0.05). LC n-3 PUFAs modified lipid profile, but not glucose tolerance. Serum leptin levels were significantly higher in HFD groups than in the control group, however, no difference in serum ghrelin levels was observed among the groups. Liver n-3 fatty acid desaturation activity was higher (p = 0.74), and liver total lipid content was lower (p = 0.86) in KO-HFD compared to FO-HFD. FADS1 gene expression was highest in the HFD group (p < 0.001) while FADS2 gene expression was highest in the FO-HFD group (p < 0.001). Conclusion LC n-3 PUFAs, especially krill oil, had moderate effects on lipid profile, but limited effects on obesity related parameters, suggesting different effects of different sources on gene expression levels. Further randomized controlled trials are needed to determine the efficacy of different LC n-3 PUFA sources in the prevention and treatment of obesity in humans.

scholarly journals MON-691 Association of Serum Level of Omentin-1, Hs-CRP and Atherosclerosis in Patients with Type 2 Diabetes

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Mohamed Fahmy Amara
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Acute Infection ◽  
Subcutaneous Fat ◽  
Control Group ◽  
Control Subjects ◽  
Significant Difference ◽  
Anti Inflammatory ◽  
Hs Crp

Abstract Omentin-1 has been identified as an interesting novel adipokine that may modulate the action of insulin. Serum omentin-1 levels were associated with endothelial dysfunction and cardiovascular diseases, which highly contribute to morbidity and mortality of patients with diabetes, however its exact biological function is still unclear. The aim of this study was to assess the level of circulating plasma Omentin-1 level in patients with type 2 diabetes compared to control subjects, and to investigate the relationship of circulating Omentin-1levels with HOMA, BMI, lipid profile, epicardial fat, visceral fat and subcutaneous fat in early stages of atherosclerosis measured by carotid intima media thickness (CIMT). This is a cross-sectional observational study which included 45 patients with type 2 DM (not previously diagnosed as ACVD patients) and 30 (age and sex)-matched healthy control subjects. Patients with a history of recent acute infection, malignancy, metabolic or endocrinal diseases, cardiac failure, renal and hepatic impairment were excluded. Participants were subjected to measurement of FPG, HbA1c, lipid profile, calculation of HOMA2, hs CRP, serum omentin-1, CIMT, estimation of visceral, epicardial and subcutaneous fat through CAT scanning. There was no statistically significant difference between both groups in the mean circulating omentin-1 level, a mean of (793.86 ± 195.81) ng/ml in type 2 diabetes Vs (804.93 ± 205.76) ng/ml in the control group,(p=0.654). However, there was a highly statistically significant difference in hs-CRP between both groups, mean hs CRP is (4.29 ± 4.87 mg/l) vs (0.92 ± 0.53 mg/l) respectively. There was a statistically significant negative correlation between omentin-1 and hs CRP (r= -0.278, p= 0.016).There were no statistically significant correlations between omentin-1 with BMI, HbA1c, HOMA, lipid profile or adiposity. These findings may denote the anti-inflammatory effects of omentin-1 which maybe unrelated to insulin resistance and dyslipidemia. Further studies are required to confirm the cardioprotective role of omentin-1 in patients with type 2 diabetes, focusing on its local anti-inflammatory role. Nothing to disclose: MA, NA, NK No Sources of Research Support

scholarly journals Effects of Intravenous Thrombolytic Therapy with Alteplase on Neurological Function, Coagulation Function and Serum Inflammatory Factors in Patients with Acute Cerebral Infarction

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Xianfang Yue ◽  
Hua Zhou
Keyword(s):  
Cerebral Infarction ◽  
Intravenous Thrombolysis ◽  
Neurological Function ◽  
Acute Cerebral Infarction ◽  
Inflammatory Factors ◽  
Control Group ◽  
Routine Treatment ◽  
Coagulation Function ◽  
Hs Crp ◽  
Thrombolysis Therapy

Objective: To investigate the effects of intravenous thrombolysis therapy with alteplase on neurological function, coagulation function and serum inflammatory factors in patients with acute cerebral infarction. Methods: A total of 96 patients with acute cerebral infarction admitted to our hospital from September 2017 to October 2019 were randomly divided into two groups, with 48 patients in each group. The control group (n=48) received routine treatment, and the observation group received intravenous thrombolysis therapy with alteplase on the basis of routine treatment. The neurological deficit score, prothrombin time(PT), activated partial thromboplastin time (APTT), tumor necrosis factor-a level (TNF-?), and high-sensitivity C-reactive protein (hs-CRP) were compared between the two groups after 15 days of treatment. Results: After treatment, NIHSS scores in both groups were lower than those before treatment; PT levels were increased, while APTT, TNF-? and hs-CRP levels were all decreased in both groups, and the changes in the observation group were greater than those in the control group, with statistically significant difference (P<0.05). Conclusions: Intravenous thrombolysis therapy with alteplase can improve the neurological function, coagulation function and serum levels of inflammatory factors in patients with acute cerebral infarction, which is worthy of clinical application.

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