scholarly journals Opioid Receptor-Dependent Sex Differences in Synaptic Plasticity in the Hippocampal Mossy Fiber Pathway of the Adult Rat

2015 ◽  
Vol 35 (4) ◽  
pp. 1723-1738 ◽  
Author(s):  
L. C. Harte-Hargrove ◽  
A. Varga-Wesson ◽  
A. M. Duffy ◽  
T. A. Milner ◽  
H. E. Scharfman
Keyword(s):  
Sex Differences ◽  
Synaptic Plasticity ◽  
Opioid Receptor ◽  
Mossy Fiber ◽  
Adult Rat ◽  
Mossy Fiber Pathway

scholarly journals Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Sang Hun Lee ◽  
David Lutz ◽  
Mohanad Mossalam ◽  
Vadim Y. Bolshakov ◽  
Michael Frotscher ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Calcium Homeostasis ◽  
Mossy Fiber ◽  
Mitochondrial Calcium ◽  
Mossy Fiber Pathway

Sex differences in synaptic plasticity underlying learning

2021 ◽  
Author(s):  
Christine M. Gall ◽  
Aliza A. Le ◽  
Gary Lynch
Keyword(s):  
Sex Differences ◽  
Synaptic Plasticity

Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling

2020 ◽  
Vol 177 ◽  
pp. 108254 ◽  
Author(s):  
Moriah L. Jacobson ◽  
Hildegard A. Wulf ◽  
Mumeko C. Tsuda ◽  
Caroline A. Browne ◽  
Irwin Lucki
Keyword(s):  
Sex Differences ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Nest Building ◽  
Receptor Signaling ◽  
Kappa Opioid ◽  
Building Behavior

Stability of synaptic plasticity in the adult rat visual cortex induced by complex environment exposure

2004 ◽  
Vol 1018 (1) ◽  
pp. 130-135 ◽  
Author(s):  
Teresita L Briones ◽  
Anna Y Klintsova ◽  
William T Greenough
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Complex Environment ◽  
Adult Rat ◽  
Environment Exposure

scholarly journals Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits

2021 ◽  
Vol 17 (10) ◽  
pp. e1009435
Author(s):  
Luke Y. Prince ◽  
Travis Bacon ◽  
Rachel Humphries ◽  
Krasimira Tsaneva-Atanasova ◽  
Claudia Clopath ◽  
...  
Keyword(s):  
Granule Cells ◽  
Mossy Fiber ◽  
Pyramidal Cells ◽  
Recurrent Network ◽  
Memory Storage ◽  
Neuronal Ensembles ◽  
Hippocampal Ca3 ◽  
Ca3 Pyramidal Cells ◽  
Episodic Memories ◽  
Mossy Fiber Pathway

In the hippocampus, episodic memories are thought to be encoded by the formation of ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy fiber inputs from dentate gyrus granule cells. The neuromodulators acetylcholine and noradrenaline are separately proposed as saliency signals that dictate memory encoding but it is not known if they represent distinct signals with separate mechanisms. Here, we show experimentally that acetylcholine, and to a lesser extent noradrenaline, suppress feed-forward inhibition and enhance Excitatory–Inhibitory ratio in the mossy fiber pathway but CA3 recurrent network properties are only altered by acetylcholine. We explore the implications of these findings on CA3 ensemble formation using a hierarchy of models. In reconstructions of CA3 pyramidal cells, mossy fiber pathway disinhibition facilitates postsynaptic dendritic depolarization known to be required for synaptic plasticity at CA3-CA3 recurrent synapses. We further show in a spiking neural network model of CA3 how acetylcholine-specific network alterations can drive rapid overlapping ensemble formation. Thus, through these distinct sets of mechanisms, acetylcholine and noradrenaline facilitate the formation of neuronal ensembles in CA3 that encode salient episodic memories in the hippocampus but acetylcholine selectively enhances the density of memory storage.

Sign in / Sign up

Export Citation Format

Share Document