scholarly journals Ultrastructural analysis of substance P-immunoreactive nerve fibers in myenteric ganglia of guinea pig small intestine

1989 ◽  
Vol 9 (1) ◽  
pp. 167-174 ◽  
Author(s):  
IJ Llewellyn-Smith ◽  
JB Furness ◽  
M Costa
Keyword(s):  
Small Intestine ◽  
Substance P ◽  
Guinea Pig ◽  
Nerve Fibers ◽  
Ultrastructural Analysis ◽  
Myenteric Ganglia

Ascending enteric reflex: multiple neurotransmitter systems and interactions

1989 ◽  
Vol 256 (3) ◽  
pp. G540-G545 ◽  
Author(s):  
P. Holzer
Keyword(s):  
Small Intestine ◽  
Substance P ◽  
Guinea Pig ◽  
Motor Neurons ◽  
Circular Muscle ◽  
Neural Pathways ◽  
Neurotransmitter Systems ◽  
Cholinergic Interneurons

Isolated segments of the guinea pig small intestine were used to examine the transmitter circuitry of the neural pathways subserving the ascending enteric reflex (AER) contraction of the circular muscle. Inflation of an intraluminal balloon provided the distension stimulus for the AER. The ascending contraction was reduced to 5% of its original amplitude by atropine and to 10% by hexamethonium, which indicates that cholinergic interneurons and cholinergic motor neurons constitute the main AER pathway. However, in the continued presence of atropine or hexamethonium for 60 min, the AER recovered to approximately 30% of its original amplitude. The atropine-resistant AER was blocked by hexamethonium and the tachykinin antagonist spantide [( D-Arg1,D-Trp7,9, Leu11]-substance P) suggesting that it involved cholinergic interneurons and tachykinin-utilizing motor neurons. The hexamethonium-resistant AER was abolished by atropine but left unaffected by spantide, suggesting the participation of as yet unidentified interneurons and cholinergic motor neurons. These findings demonstrate that the AER is mediated by multiple neural pathways with different transmitters and that adaptive interactions between these pathways take place after blockade of one of its neurotransmitters systems.

Projections of substance P-containing neurons within the guinea-pig small intestine

Neuroscience ◽  
1981 ◽  
Vol 6 (3) ◽  
pp. 411-424 ◽  
Author(s):  
M. Costa ◽  
J.B. Furness ◽  
I.J. Llewellyn-Smith ◽  
A.C. Cuello
Keyword(s):  
Small Intestine ◽  
Substance P ◽  
Guinea Pig

Proteolytic Inactivation of Substance P and Neurokinin A in the Longitudinal Muscle Layer of Guinea Pig Small Intestine

2006 ◽  
Vol 47 (3) ◽  
pp. 856-864 ◽  
Author(s):  
R. Nau ◽  
G. Schäfer ◽  
C. F. Deacon ◽  
T. Cole ◽  
D. V. Agoston ◽  
...  
Keyword(s):  
Small Intestine ◽  
Substance P ◽  
Guinea Pig ◽  
Longitudinal Muscle ◽  
Muscle Layer ◽  
Neurokinin A ◽  
Longitudinal Muscle Layer
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